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Description:

This Week in Parasitism (TWiP) is a podcast about eukaryotic parasites started by Vincent Racaniello, Dick Despommier and Daniel Griffin.

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Podcast Episode's:
TWiP 137: An aberrant encounter
<p>The TWiPtoids solve the case of the Man from India with a Neck Lump, and explore the role of a transmissible dysbiotic skin microbiome in inflammation during cutaneous leishmaniasis.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" rel="noopener">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank" rel= "noopener">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank" rel="noopener">Daniel Griffin</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/28669672" target= "_blank" rel="noopener">Transmissible dysbiotic skin microbiome</a> in cutaneous leishmaniasis (Cell Host Microbe)</li> <li><a href="http://www.microbe.tv/twip/twip-137-letters/" target= "_blank" rel="noopener">Letters read</a> on TWiP 137</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to <a href="http://www.blueapron.com/twip" target="_blank" rel="noopener">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 137</h3> <p>Little town in DR, fall of 2016, have already mentioned this patient; little boy 2-3 years old, not behaving well, warned if doesn’t behave, los gusanos will eat you! Mother asks Daniel to help son: lately is more irritable, troublesome, not well behaved; notices things in his hair. Has small poppy seed sized things on side of hair shafts. She picks them off in fingers and smashes them. What are they, what do I do? Simple dwelling, dirt floor, walls and tin roof, animals everywhere. No money for medicines, what can she do?</p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target="_blank" rel= "noopener">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank" rel="noopener">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 136: Daniel throws a softball
<p>The TWiP Titans solve the case of the Man from Queens with a Blister Burster, and explain the role of inflammatory monocytes during <em>Leishmania</em> infection of the skin.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" rel="noopener">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank" rel= "noopener">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank" rel="noopener">Daniel Griffin</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Inflammatory monocytes and skin <em>Leishmania</em> (PLoS Path)</li> <li>Dracunculiasis (<a href= "http://www.microbe.tv/twip/37-dracunculiasis/" target="_blank" rel="noopener">TWiP 37</a>)</li> <li>Photo: Daniel using a <a href= "http://www.vestergaard.com/lifestraw-guinea-worm" target="_blank" rel="noopener">LifeStraw</a></li> <li><a href="http://www.microbe.tv/twip/twip-136-letters/" target= "_blank" rel="noopener">Letters read</a> on TWiP 136</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to <a href="http://www.blueapron.com/twip" target="_blank" rel="noopener">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 136</h3> <p>Patient seen by Daniel in India, 18 yo Islamic college student, left home, living in dorms in south, Hindu couple prepare meals, called dorm parents. He is being seen because developed lump in left side of neck, 1-2 cm mass. Previously completely healthy, no med/surg, no allergies. Prays multiple times a day, observes dietary restrictions. Afebrile, normal, but has 2 cm firm nontender lump inside interior portion of sternocleido mastoid muscle. Not tender. End of November, rainy season. No screens on dorm windows. No animal contact. Ultrasound done, and was helpful. Noticed in his neck over several weeks.</p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target="_blank" rel= "noopener">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank" rel="noopener">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 135: Embryonated eggs of wisdom
<p>Dickson returns to the TWiP hosts to solve the case of the Woman from Colorado With Loose Stools, and explain how single-sex infection with female <em>Schistosoma mansoni</em> reduces hepatic fibrosis.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" rel="noopener">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank" rel= "noopener">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank" rel="noopener">Daniel Griffin</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><a href="http://bit.ly/asmgwoc17" target="_blank" rel= "noopener">ASM Grant Writing Online Course</a></li> <li><a href= "http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005595" target="_blank" rel="noopener">Single-sex</a> <em>Schistosoma</em> infection (PLoS NTD)</li> <li><a href= "http://www.asterix.com/the-collection/albums/asterix-the-gaul.html" target="_blank" rel="noopener">Asterix the Gaul</a></li> <li><a href="http://www.microbe.tv/twip/twip-135-letters/" target= "_blank" rel="noopener">Letters read</a> on TWiP 135</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to <a href="http://www.blueapron.com/twip" target="_blank" rel="noopener">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 135</h3> <p>Patient seen in clinic by Daniel's colleague, living in Queens, needs home care. Man with wound on foot, needed daily care. Living 9 months, recently developed painful blister, he put his foot in water, got great relief, blister opened up. Open lesion did not look normal, there was something in blister. Went to see parasitologist, saw something there, wrapped it around piece of wood. Not previously seen a physician, no surgeries, knew little family history. New to our country, where could he have possibly come from? Rural part of some country. Resource limited region. How many days of treatment will he need?</p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target="_blank" rel= "noopener">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank" rel="noopener">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 134: Does toxoplasma make you sexy?
<p>Daniel and Vincent solve the case of the Haitian Girl Who Failed To Thrive, and visit two studies that address the question of whether infection with <em>Toxoplasma gondii</em> alters human behavior.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a> and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p> </p> <h3>Links for this episode:</h3> <ul> <li>ASM Grant Writing Online Course</li> <li>Is <em>Toxoplasma</em> infection related to <a href= "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148435" target="_blank">brain and behavior impairments</a>? (PLoS One)</li> <li><em>Toxoplasma</em> infection and <a href= "http://journals.sagepub.com/doi/10.1177/1474704916659746" target= "_blank">sexual attraction</a> (Evol Psychol)</li> <li><a href= "http://www.microbe.tv/twip/undefinedtwip-21-the-giant-intestinal-worm-ascaris-lumbricoides/"> <span style="font-weight: 400;">TWiP 21 - The giant intestinal worm, Ascaris lumbricoides</span></a></li> <li><a href="https://en.wikipedia.org/wiki/Candiru" target= "_blank">Candiru</a> (Wikipedia)</li> <li><a href= "https://www.theloop.com.au/hsiehyichaun/portfolio/pinworm-test-sticker/197674" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-134-letters/" target= "_blank">Letters read</a> on TWiP 134</li> </ul> <h3>Case Study for TWiP 134</h3> <p><span style="font-weight: 400;">Woman in 30s, coming in Colorado to be seen, reports foul smelling loose stools multiple times each day, cramping and nausea. Started a few weeks ago. No fever, summer, no unusual travel, skiing up in mountains, hiking, backpacking. Originally from NE, moved to Colorado one year before. Often drinks from streams. Treats water with iodine. On overnight trips pack food and cook on stoves. Sticky stools, trouble wiping clean. Yes, my stools do float. Color, not as dark. Well formed. No medical problems, no surgeries, no allergies. Takes no medications. Lives alone in private home. Drinks beer, no other toxic habits. None of her friends report similar problems. Sexually active, does not always use protection. Physical exam: unremarkable.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 133: Tape test
<p>Daniel and Vincent solve the case of the Woman With Anal Area Discomfort, and discuss the multiple functions of a clathrin adapter protein in formation of rhoptry and microneme secretory organelles of <em>Toxoplasma gondii</em>.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a> and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Journal of Microbiology and Biology Education SciComm Issue (<a href="http://asmscience.org/jmbe" target= "_blank">link</a>)</li> <li><span style="font-weight: 400;"><a href= "http://www.microbe.tv/twip/19-enterobius-vermicularis-the-pinworm/"> TWiP 19: Enterobius vermicularis, the pinworm</a></span></li> <li>Multiple roles of <em>Toxoplasma gondii</em> <a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006331" target="_blank">clathrin adaptor AP1 protein</a> (PLoS Path)</li> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006331" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-133-letters/" target= "_blank">Letters read</a> on TWiP 133</li> </ul> <h3>Case Study for TWiP 133</h3> <p><span style="font-weight: 400;">Seen while working in remote mountain makeshift mobile clinic in Dominican Republic, on Haitian border. Traveled 3 h by pickup truck, remote mountain town, womens centers. Set up makeshift mobile clinic in this center. Mother concerned about 6 yo girl, failure to thrive compared with sister, protuberant belly, frequent abdominal discomfort, going on over 1 year. No surgeries, no meds, first time ever seeing medical person. Mother and sister are family. Three children in family. Father does timber work. Very impoverished region, living in dirt floor home, drinking untreated water from local stream, go to bathroom outside, could be contamination. Diet: carbohydrate, plantains, rice, beans. On exam: lungs clear, heart fine, belly protuberant, liver and spleen not enlarged, some edema. Mother said noticed long motile worm in girls feces. Firm belly, not painful to her.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 132: Salted crab som tum
<p>The TWiP-tastic peeps solve the case of the Thai Man Coughing Up Blood, and reveal potential therapies for trypanosomiasis that are inhibitors of protein import into glycosomes.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Inhibitors of protein import into <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28360328" target= "_blank">trypanosome glycosomes</a> (Science)</li> <li>Hookworm (<a href="http://www.microbe.tv/twip/22-hookworm/" target="_blank">TWiP #22</a>)</li> <li>Photo by Nita</li> <li><a href="http://www.microbe.tv/twip/twip-132-letters/" target= "_blank">Letters read</a> on TWiP 132</li> </ul> <h3>Case Study for TWiP 132</h3> <p><span style="font-weight: 400;">Young NYC woman with son (10), chief complaint of discomfort and itchiness in anal area. Has tried to look but nothing abnormal. Married, no complaints from husband or child. Two older kids have no complaints. But son has also been scratching in anal area. Everything fine 3 months ago, sister came to visit with 3 young pre-school children, may have caught something from them. No past med or surg history, no allergies. No meds, work out of home, no toxic habits, no recent travel. Have dog. Do lots of volunteering with children. History of sushi consumption. She does not like raw fish but son does. Worse itching at night. Going on for a number of weeks. Reports being under a lot of stress recently due to family.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 131: Entomophagy
<p>Jonathan from the podcast Arthro-Pod joins the TWiPerati to solve the case of the Peruvian Woman With Inguinal Insect Bite, and discuss warm autoimmune hemolytic anemic that develops after babesiosis.</p> <p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>Guest:  <a href="http://arthro-pod.blogspot.com/" target= "_blank">Jonathan Larson</a></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><a href= "http://extension.unl.edu/statewide/douglas-sarpy/jonathan-larson-phd/" target="_blank">Jonathan Larson</a> (<a href= "http://www.twitter.com/JLarson_UNL" target="_blank">Twitter</a>, <a href="https://plus.google.com/116819210958795949643" target= "_blank">Google Plus</a>)</li> <li><a href="http://arthro-pod.blogspot.com/" target= "_blank">Arthro-Pod</a> podcast</li> <li>Warm hemolytic anemia after <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28273010" target= "_blank">babesiosis</a> (NEJM)</li> <li><a href="https://www.cdc.gov/ticks/diseases/" target= "_blank">Tickborne diseases</a> of the US (CDC)</li> <li><a href="https://species.wikimedia.org/wiki/Babesia" target= "_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-131-letters/" target= "_blank">Letters read</a> on TWiP 131</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to <a href="http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 131</h3> <p><span style="font-weight: 400;">Thailand. 39 yo man reports 7 months of coughing up bright red blood, several times with mucus. Otherwise feels well. Big fan of salted crab som tum. Fisherman, lives with family. Healthy, no past med/surg problems. No meds. On seeing him: afebrile, chest xray abnormal: area of increased opacification. Not a smoker. No toxic habits.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 130: Paige Turner
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style= "font-weight: 400;">TWiPniks </span>solve the case of the Man With AIDS, and explore how secretion of extracellular vesicles influences the social motility of <em>Trypanosoma brucei</em><span style="font-weight: 400;">.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><em>T. brucei</em> <a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006245" target="_blank">exosomes and social motility</a> (PLoS Path)</li> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006245" target="_blank">Image credit</a></li> <li><a href="http://www.parasiteswithoutborders.com" target= "_blank">Parasites Without Borders</a></li> <li><a href="http://www.microbe.tv/twip/twip-130-letters/" target= "_blank">Letters read</a> on TWiP 130</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to <a href="http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 130</h3> <p><span style="font-weight: 400;">Back in Peru. 24 yo female seen in ER, lives in rural area outside of big city, adobe house in highlands, thatched roof, dirt floor, 3000 meters. Quite ill with skin lesion for 48 h. 2 days before was pulling on pjs, felt sharp sudden pain in right upper leg. Next day found small living creature in pajamas, inguinal region. Developed red lesion, enlarged, developed black central dot. Then begins vomiting, comes to hospital. No fever, breathing fast 20, hr 70, bp 160/10, on exam see in right inguinal region an enlarging, necrotic area 1-2 cm, starting to look sick. Whites at 26000, left shift, 200 platelets, eosinophils 4%, bilirubin 3.5, creatinine 4.9 (going into renal failure, not making much urine). Hematocrit 14, BUN 59.7, CPK 227, RBCs and leukocytes in urine. No health problems, no surgeries, first interaction with health system. No toxic habit. Brings in the small creature!</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
Listen: podcast - audio/mpeg

TWiP 129: Human kindness, river blindness
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style="font-weight: 400;">TWiP Masters </span>solve the case of the Australian Wildlife Carer, and review evidence that nodding syndrome may be caused by an autoimmune reaction to the parasitic worm that causes river blindness<span style="font-weight: 400;">.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Nodding syndrome an <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28202777" target= "_blank">autoimmune disease?</a> (Sci Transl Med)</li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/28202778" target= "_blank">Nodding syndrome</a>: Preventable and treatable (Sci Transl Med)</li> <li><a href= "https://play.google.com/music/preview/Tqlxofhnwkorijd7rezdn26fpiq?lyrics=1&utm_source=google&utm_medium=search&utm_campaign=lyrics&pcampaignid=kp-lyrics" target="_blank">River Blindness</a> lyrics (Google Play)</li> <li><a href= "https://en.wikipedia.org/wiki/Onchocerca_volvulus#/media/File:Onchocerca_volvulus_emerging_from_a_black_fly.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-129-letters/" target= "_blank">Letters read</a> on TWiP 129</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to <a href="http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 129</h3> <p><span style="font-weight: 400;">Young male in 30s, presents to ER with male partner, NY area, chief complaint over 1 month significant diarrhea, watery, non bloody. Abdominal cramping. Feels poorly, low energy, fever. Some vomiting, lost noticeable amount of weight, can’t stay hydrated. Past: AIDS positive, not on meds, last CD4 <50, viral load elevated and uncontrolled. Non contributory family history, no meds. Social history: had worked in office, can no longer; lives with male partner; occasional alcohol, no pets, no other significant exposures. Partner also AIDS, also not on therapy. Physical: febrile, 38.5C, 115 bp, 95/65, 18 resp, thin male, clearly uncomfortable. Oral thrush in buccal mucosa. No subungual saliva. Lungs clear, abdomen diffusely tender, increased bowel sounds. Labs: elevated creatinine, BUN, decreased sodium, elevated WBC count with significant eosinophilia. No pets or houseplants. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
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TWiP 128: It's over 9000!
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style= "font-weight: 400;">TWiPerati </span>solve the case of the Man Who Sat in Feces, and discuss a study on how Dickson's favorite parasite induces the formation of a collagen capsule.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Induction of <a href= "http://dx.doi.org/10.1016/j.vetpar.2016.11.001" target= "_blank">collagen synthesis</a> by <em>Trichinella</em> (Vet Parasitol)</li> <li><a href="http://www.microbe.tv/twip/twip-128-letters/" target= "_blank">Letters read</a> on TWiP 128</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to <a href="http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 128</h3> <p><span style="font-weight: 400;">Daniel doesn’t expect anyone to get this. From Australia, 80 yo retired teacher from Atherton, northheast Australia, presents to clinic with generalized weakness, concern of chronic lyme or Q fever. Seen by neurologist, concern about motor neuron disease. 18 months of illness, insidious onset of limb (arms and legs) weakness. No issues with speaking, swallowing or breathing; no weight loss; no fever, sweat, chill. History of osteoarthritis, joint replacements; myocarditis; vertigo; allergic to pen and dox. Father, rhematoid arthritis, brother colon cancer. On a number of medications. Does extensive travel, when not traveling, is a volunteer carer in Australia (abandoned wildlife), over the past three years. Lives with husband. Marsupials, hand feeds puggles and juvenile spiny anteaters, has pet cockatoo. No history of polio, HIV negative. Neuro exam: diffuse non tender muscle with no rash. Normal upper and lower limb tone, strength is symmetrically reduced proximally. Reflexes good at knees, normal sensation to all modalities. Normal cranial nerve exam. Test results: has eosinophilia, elevated muscle enzymes, EMG shows myopathic changes, nerve conduction normal. Stop statin therapy, no change. This is a rare parasite.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p> <p>Music by <a href="http://www.ronaldjenkees.com" target= "_blank">Ronald Jenkees</a></p>
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TWiP 127: Kava not Cava
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style= "font-weight: 400;">TWiPsters</span> solve the case of the Peace Corps Volunteer with a Liver Lesion, and discuss the dependence of <em>Leishmania</em> survival on the gut microbiome of the sandfly.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><em>Leishmania</em> depends on <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28096483" target= "_blank">sandfly gut microbiome</a> (mBio)</li> <li><a href="https://en.wikipedia.org/wiki/Kava" target= "_blank">Kava</a> (Wikipedia)</li> <li><a href="http://www.microbe.tv/twip/twip-127-letters/" target= "_blank">Letters read</a> on TWiP 127</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to <a href="http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 127</h3> <p><span style="font-weight: 400;">The last of our trio for the Peace Corp, an eosinophilia case. 29 yo pc volunteer in Rwanda, male, 3 weeks of feeling poorly. Starts with rash on lower back and upper legs, maculopapular rash. Fatigue later, cough, then diarrhea, 51% eosinophils (9000). No significant exposure to fresh water. Stool sent for oandp. Said sat down and got something on behind, realized later was feces, this was where rash developed. OandP seeing larva in stool. HIV neg, no med issue, no surgeries, no Kava. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 126: A virus walks into a parasite
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style= "font-weight: 400;">TWiP Trinity</span> solve the case of the Peace Corps volunteer with diarrhea, and reveal how immunizing against a virus ameliorates exacerbated leishmaniasis.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><span style="font-weight: 400;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28099431" target= "_blank">Viral vaccine</a> prevents exacerbated leishmaniasis (PLoS NTD)</span></li> <li>For whom the trich tolls (<a href= "http://www.microbe.tv/twip/47-for-whom-the-trich-tolls/" target= "_blank">TWiP 47</a>)</li> <li><a href= "http://www.virology.ws/2015/09/17/a-virus-in-a-parasite-in-a-human/" target="_blank">A virus in a parasite</a> in a human (virology blog)</li> <li>Virologists in the mist (<a href= "http://www.microbe.tv/twiv/twiv-128-virologists-in-the-mist/" target="_blank">TWiV 128</a>)</li> <li><a href="http://www.microbe.tv/twip/twip-126-letters/" target= "_blank">Letters read</a> on TWiP 126</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free - WITH FREE SHIPPING - by going to <a href= "http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 126</h3> <p><span style="font-weight: 400;">Another Peace Corps volunteer in Fiji. 24 yo male, several days of fever, headache, dry cough, rash. Feels poorly, starts diarrhea. No blood or mucus, no vomiting but abdominal discomfort. Heart rate over 100. At private nearby hospital for evaluation: no prior med probs or surgeries. Social history: MSM, not always protected, drinks every weekend. Home blown away by cyclone. Alcohol: drinks beer, a lot. White rice, split peas, bread diet. Fan of cava, also drank unfiltered water. He is admitted, continues to feel poorly. Continued fevers, localized abdominal pain RUQ. On exam he has tender palpable liver, elevated WBC 17.8, eosinopenia, 0 cells. AST/ALT slightly above normal. Dengue, chick, lepto, blood all negative. Ultrasound of liver: shows 8x8 cm mixed echogenic lesion in right lobe. HIV negative. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 125: Third time's a charm
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style= "font-weight: 400;">TWiPonderers</span> solve the case of the Timber Worker with Severe Shaking Chills, and describe an experimental malaria vaccine comprising attenuated sporozoites produced by genetic engineering.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><span style="font-weight: 400;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28053159" target= "_blank">Genetically engineered</a> <em>P. falciparum</em> sporozoite vaccine (Sci Transl Med)</span></li> <li>Parasitology Superhero: <a href= "https://en.wikipedia.org/wiki/Francesco_Redi" target= "_blank">Francesco Redi</a></li> <li>Image credit: Betsy Weissbrod</li> <li><a href="http://www.microbe.tv/twip/twip-125-letters/" target= "_blank">Letters read</a> on TWiP 125</li> </ul> <p>This episode of TWiP is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free - WITH FREE SHIPPING - by going to <a href= "http://www.blueapron.com/twip" target= "_blank">blueapron.com/twip</a>.</p> <h3>Case Study for TWiP 125</h3> <p><span style="font-weight: 400;">Thanks to the Peace Corps - 24 yo female serving in Cameroon, teaching English and science at local school. Been in country 5 months, first 3 lived with host family, now in own home in community with electricity, 12 hr from Yaounde, capital. Reports intermittent diarrhea, loose stools, abdominal discomfort. No prior problems, no problems in family. No meds. No drinking or smoking. Lots of animals present, roam into class. Eating all local fare, cooks some, or buy locally. Eats fish, vegetables, no fish. Sleeps in house with mosquito nets. Not sexually active, AIDS negative. Young kids at school 6-12 yo, 20 in room. Does not eat at school. Not clear if water is treated. Not on antimalarials. Going on for a few a few weeks. No fever, no rash.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 124: RPAing with the tryps
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The <span style="font-weight: 400;">prolific podcast-shedding Hosts</span> solve the case of the Global Health Intern with a snakelike lesion on her foot, and reveal the role of a single-stranded DNA binding protein in differentiation of trypanosomes.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>RPA protein and <a href= "http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005181" target="_blank">differentiation</a> of <em>T. cruzi</em> (PLoS NTD)</li> <li><a href= "https://www.cdc.gov/dpdx/images/trypanosomiasisAmerican/Tcruzi_thin_giemsa5_zoom.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-124-letters/" target= "_blank">Letters read</a> on TWiP 124</li> </ul> <h3>Case Study for TWiP 124</h3> <p><span style="font-weight: 400;">28 yo male from referral hospital near thai-burma border. Fever and chills 2 days, feels poorly, small amount of dark urine. Severe shaking chills, 1x per day, no rash. No diarrhea, difficulty breathing. Seen by local health care volunteer, went to hospital then tertiary hospital in Bangkok. Exposure history to pigs, dogs, insects, etc. Involved in timber industry and farming, sleeping out at night with no cover, clothes and sandals. No meds. Not married, family lives with him. Family is fine. Sleep in dwelling but no screens. No toxic habits, HIV negative, sexually active but not brothels. High fever, low bp, rapid heart rate, breathing rapidly, scleral icterus, dry mucus membranes, neck supple, lungs clear. 2/6 systolic murmur. Abdomen soft but tender, enlarged liver and spleen. Many cuts, bruises, bug bites. Labs: low platelets, low hematocrit, low glucose. Blood smear: abnormal, 5-10% infected RBCs with multiple band forms. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 123: What we know is confusing
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com/who-we-are/" target= "_blank">Daniel Griffin</a></p> <p>The TWiPanorama solve the case of the Dutch Woman with Wormy Objects in Her Stool, dissect a study on cytoadhesion of malaria infected red blood cells, and introduce Parasitology Superheroes.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><a href="https://en.wikipedia.org/wiki/Myiasis" target= "_blank">Myiasis</a> (Wikipedia)</li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27835682" target= "_blank">Cytoadhesion</a> of <em>Plasmodium</em> in severe malaria (PLoS Path)</li> <li><a href= "https://www.agric.wa.gov.au/citrus/fruit-fly-western-australia" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-123-letters/" target= "_blank">Letters read</a> on TWiP 123</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <h3>Case Study for TWiP 123</h3> <p><span style="font-weight: 400;">Nurse in early 20s, recent grad, decides to spend year in global health internship in western DR/Haitian border. On her foot has skin issue: told is fungal infection, using antifungal cream, is getting worse. Several days, only on one foot. Healthy, no past med/surg/allergies, no meds, no HIV, lives with local family. Daughter, wife, husband, cat. No toxic habits. Originally from US, swims, walks barefoot to and from, shoes off in house. Easts local food, exposure to dogs, cats, sister. Very itchy, but not open; rash area is raised. Blistery in certain areas, involves different areas in different days, snakelike. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 122: If the thunder don't get you, the lightning will
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com" target="_blank">Daniel Griffin</a></p> <p>The TWiPniks docs solve the case of the Female from Peru with E<span style= "font-weight: 400;">pistaxis</span>, and discuss the effect of community deworming on immunosuppression.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Community deworming and immune hyporesponsiveness (PNAS)</li> <li>Paul C. Beaver (<a href= "http://libguides.tulane.edu/famousalumni/PCBeaver" target= "_blank">one</a>, <a href= "https://www.jstor.org/stable/3284436?seq=1#page_scan_tab_contents" target="_blank">two</a>)</li> <li>Photo by Oscar Adam Oscarson</li> <li><a href="http://www.microbe.tv/twip/twip-122-letters/" target= "_blank">Letters read</a> on TWiP 122</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p><span style="font-weight: 400;">This show is sponsored by Drobo, a family of safe, expandable , yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20.</span></p> <p><strong>Case Study for TWiP 122</strong><br /> <span style="font-weight: 400;">First of a series of cases with a theme, a 23 yo female international aid worker, chief complaint of diarrhea. Dutch descent, born in US, been in rural area of western DR, close to Haitian border. It’s been raining, houses have tin roofs, other flat concrete, rainwater pours off. Child comes by with mangoes, she buys one, washes it in rain water from the roof. Bites open mango, peels it, eats mango. The same night she is not feeling well, loose stools, abdominal discomfort. Next day, goes with group to border town; then has full fledged diarrhea. Looks into toilet, sees white objects 1 cm in length on stool, and they are moving. Uniform width, thinner than long, wormy looking. Has been participating in other activities in this area, swims in local river, walks barefoot, eating lot of local foods. Lunch: rice, beans, cooked meat, avocado. Dinner, yucca, fried salami, etc. Healthy before, no family history, not on meds, living with one of local families, no toxic habits. Dogs, cats, pigs, chickens around. One month earlier, cat in family home had kittens, she played with them. Very excited about that. Local physician contacted, he treats her. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 121: A parasite without borders
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com" target="_blank">Daniel Griffin</a></p> <p>The TWiPanosome docs solve the case of the Mali Man with Profuse Diarrhea, and review the presence of <em>Trypanosoma cruzi</em> in vectors, canids, and humans along the Texas-Mexico border.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><em>T. cruzi</em> in vectors, canids, humans <a href= "https://www.ncbi.nlm.nih.gov/pubmed/27832063" target= "_blank">at Mexican border</a> (PLoS NTD)</li> <li><a href= "https://en.wikipedia.org/wiki/Tetracapsuloides_bryosalmonae" target="_blank"><em>Tetracapsuloides bryosalmonae</em></a> (Wikipedia)</li> <li><em>T. cruzi</em> <a href= "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194829/" target= "_blank">in US</a> (Clin Micro Rev)</li> <li><a href= "http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005074" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-121-letters/" target= "_blank">Letters read</a> on TWiP 121</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <h3>Case Study for TWiP 121</h3> <p><span style="font-weight: 400;">Back to Peru. 55 yo female from highland central valley area near Cuzco. Works in farming, no prior skin lesions but has multiple hypopigmented scars on exposed extremities (trauma during working), now reports many years of bloody nasal discharge. Seen in Lima by Daniel in outpatient clinic. No other medical problems, no surgeries, no allergies, everyone in family fine, husband and kids. Still working. No travel except to see doctor. Exam in right nare: ulcerated lesion inside nose, muco-cutaneous lesion. Simple test will decide. No anemia, no fever. Not eosinophilic, labs normal, HIV negative.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 120: When they die they calcify
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.verticalfarm.com" target="_blank">Dickson Despommier</a>, and <a href= "http://www.parasiteswithoutborders.com" target="_blank">Daniel Griffin</a></p> <p>The TWiP triumvirate solve the case of the Thai Woman with Facial Swelling, and explain how Th17 T cells protect against the intracellular parasite <em>Trypanosoma cruzi</em>.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005902" target="_blank">Th17 cells protect</a> against <em>Trypanosoma cruzi</em> (PLoS Path)</li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/20185720" target= "_blank">Plasticity</a> of helper CD4+ cells (Science)</li> <li>Image credit</li> <li><a href="http://www.microbe.tv/twip/twip-120-letters/" target= "_blank">Letters read</a> on TWiP 120</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <h3>Case Study for TWiP 120</h3> <p><span style="font-weight: 400;">A 48 yo man from Mali comes to hospital ER in Washington Heights in NY with profuse watery diarrhea. Born in Mali, came to US at 18, working in US as long haul truck driver for 30 y, frequently visits Mali, recently to attend his father’s funeral. Got symptoms one week after return (was there for 3 weeks). 3 liters diarrhea/day. No past med/surg history, not seen doctor in long time. No allergies. Unknown what father died of, Mother in Mali is ok. No medications. Some alcohol, marijuana use. Does report that has exposure to professional female sex workers, no condoms. Temp of 39 C, bp down 80/40, heart over 110, rapid breathing high 20s, cachectic. Wasted. Fungating lesion perianally. Undergoes HIV testing, clade B. T cells <100. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 119: A kinder and gentler case
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello </a>and Daniel Griffin</p> <p>Vincent and Daniel solve the case of the Family with Eosinophilia, and discuss HIV-1 infection and genome integration in the blood fluke <em>Schistosoma mansoni</em>.</p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Links for this episode:</h3> <ul> <li>Family cluster of <a href= "http://cid.oxfordjournals.org/content/57/6/845.long" target= "_blank">eosinophilia</a> (Clin Inf Dis)</li> <li><a href="https://en.wikipedia.org/wiki/Dientamoeba_fragilis" target="_blank"><em>Dientamoeba fragilis</em></a> (Wikipedia)</li> <li><a href="http://parasiteswithoutborders.com" target= "_blank">Parasites without borders</a></li> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005931" target="_blank">HIV integrates</a> into <em>Schistosoma</em> genome (PLoS Path)</li> <li><a href= "https://en.wikipedia.org/wiki/Schistosoma_mansoni#/media/File:Schistosoma_mansoni2.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-119-letters/" target= "_blank">Letters read</a> on TWiP 119</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <h3>Case Study for TWiP 119</h3> <p><span style="font-weight: 400;">This one will be kinder and gentler case. Back in Thailand but could be in several places. 25 yo Thai woman from Bangkok, to hospital, chief complaint facial swelling. Eats typical Thai diet (see previous episodes!) Som tum, etc fish that is not cooked. Migratory - moves around face. Not tender, but mild itchiness. For about a week, no pain. Healthy, no past med/surg history, family all fine. HIV negative, no drugs, no travel. On examination, has swelling on right side, 3-4 cm raised, little redness, firm, does not feel like fluid filled. No fever, no GI problems, no bloods. WBC up, eosinophils up. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 118: Crispr capers with Toxoplasma
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPinella solve the case of the Woman from Guinea, and describe the use of CRISPR/Cas9 to identify essential apicomplexan genes.</p> <h3>Links for this episode:</h3> <ul> <li>Malarias in <a href= "https://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/yellow-fever-malaria-information-by-country/guinea#seldyfm707" target="_blank">Guinea</a> (CDC)</li> <li>Genome-wide <a href= "http://www.cell.com/cell/fulltext/S0092-8674(16)31070-4?rss=yes" target="_blank">CRISPR screen</a> in <em>Toxoplasma</em> (Cell)</li> <li><em>Plasmodium</em> parasitemia associated with <a href="https://www.ncbi.nlm.nih.gov/pubmed/27531847" target="_blank">increased Ebola survival</a> (Clin Inf Dis)</li> <li><a href= "http://apiloc.biochem.unimelb.edu.au/apiloc/images/apicomplexan.png?1317186147" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-118-letters/" target= "_blank">Letters read</a> on TWiP 118</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 118</h3> <p><span style="font-weight: 400;">Little bit of a twist - a human family with eosinophilia. Conveyed by good friend/colleague ID physician. Australia, NSW, 45 yo Dad, having problem with mild abdominal distention. Seen by doc in Sydney, CBC shows eosinophil count of 10,500. Wife of same age reports feeling fine, but gets CBC and also shows eosinophils of 5,200. Two daughters, 17 and 19, no symptoms, bloods: 900 and normal eosinophils. One week prior to dads symptoms, sister in law came (also in NSW) and stayed, developed severe diarrhea, discomfort, bloating, weight loss, eosinohils 4,700. Eat raw fish (not known if fresh or salt) purchased at local markets. No overseas travel or out of urban environment. No pets, no home grown foods. Went back to previous labs and found normal eosinophil levels. Full workup for strongyloides, all negative. No HIV. No toxic habits, no remarkable medical history.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 117: Parasitic puzzles
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The parasite prophets solve the case of the Thai Man with Abdominal Distention, and discuss the finding that m<span style="font-weight: 400;">etastatic leishmaniasis dependent on a virus can be prevented by blocking IL-17A</span>.</p> <h3>Links for this episode:</h3> <ul> <li><a href= "http://www.microbe.tv/twip/27-trematodes/"><span style="font-weight: 400;"> TWiP 27: Trematodes</span></a></li> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005852" target="_blank">Leishmaniavirus and IL-17A dependent</a> leishmaniasis (PLoS Path)</li> <li><a href="http://viralzone.expasy.org/all_by_species/648.html" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-117-letters/" target= "_blank">Letters read</a> on TWiP 117</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 117</h3> <p><span style="font-weight: 400;">Woman 66 yo born in Guinea, grew up the moved to US past 10 years, just retired. Lives in Washington Heights. Mother having issues in Guinea, so went back for 3 months in 2016. Just came back a week ago, reporting headache, fever, feeling poorly. Staying in big city, with Mom (80s). Has own private toilet in nice home. No screens or bednets. Married for 40 years, recently divorces. Has had 10 children. Not sexually active. Starts with high fever, breaks, then 2 days later another for several hours, goes to ER. Given Ebola screening questions, negative, do some blood work, send her back out. 2-3 days later high fever, double vision, headache, comes to Columbia ER. No diarrhea, no urination discomfort. Has backache, feels that mouth is dry. Was admitted. Past med history: high bp, cholesterol, diabetes; not overweight; appendix out; has unknown reaction to novocaine. No smoking, drinking. Physical: 39.4 temp, 14-16 breath rate, heart rate over 100, rapid heartbeat, 2/6 systolic murmur with radiation to left carotid (flow murmur). No jugular venous distention. Abdomen right upper quadrant: slight enlargement of liver, not tender, can palpate spleen tip in left upper quadrant, slightly enlarged spleen. Normal bowel sounds, no rash. Blood: elevated white count, bands 9%. 0.1 eosinophils, platelets 79, hemoglobin 11. Bilirubin 1.5, bicarb 20, chest xray clear. Red cells: small, 79.4 mcv. Animals: don’t like animals! In middle of rainy season. Likes to walk outside in rain during day. No cats to keep out rodents. Food: all food is prepared in home. Eats all favorite foods: rice. No sick contacts, no exposure to health care setting, no bug bites. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 116: One drug to rule them all
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPtoids solve the case of the Thai Fisherman with Chronic Diarrhea, and reveal a potential new drug for treatment of leishmaniasis, Chagas diseases, and sleeping sickness.</p> <h3>Links for this episode:</h3> <ul> <li><a href= "https://en.wikipedia.org/wiki/Capillaria_philippinensis" target= "_blank"><em>Capillaria philippensis</em></a> (Wikipedia)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/27501246" target= "_blank">Proteasome inhibitor</a> for three parasitic diseases (Nature)</li> <li><a href= "https://en.wikipedia.org/wiki/One_Ring#/media/File:Unico_Anello.png" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-116-letters/" target= "_blank">Letters read</a> on TWiP 116</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 116</h3> <p><span style="font-weight: 400;">This week's case i</span><span style="font-weight: 400;">nvolves no math. 36 year old Thai man from the northeast part of the country. Comes in with abdominal distention. Eats a normal Thai diet - Som Tam, Koi Pla, lots of rice. Feels well, came in because he is getting yellowing of skin and whites of eyes - jaundiced. Previously healthy, no prior med prob or surgery. No diseases running in family. Fisherman in the northeast (freshwater). Wife and many children, monogamous, HIV negative. Lives in jungle area, near river, many dogs, chickens, monkeys, goats, cows, pigs. Bathroom is outside. No fever, thin. Distention going on for months. Getting bigger. Exam: jaundiced, has large palpable non-tender mass below liver on his right side. No enlarged liver or spleen. No travel. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 115: The Cuscuta Factor
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPlets solve the sad case of the Boy Who Went Swimming, and explain why the tomato is resistant to the plant parasite <em>Cuscuta</em>.</p> <h3>Links for this episode:</h3> <ul> <li>Detection of plant parasite by a <a href= "http://www.ncbi.nlm.nih.gov/pubmed/27471302" target= "_blank">tomato receptor</a> (Science)</li> <li><a href="https://en.wikipedia.org/wiki/Cuscuta" target= "_blank">Dodder</a> (Wikipedia)</li> <li><a href="http://www.microbe.tv/twip/77-mixed-messages/" target= "_blank">Mixed messages</a> (TWiP 77)</li> <li><a href= "https://en.wikipedia.org/wiki/Cuscuta#/media/File:Cuscuta_europaea_2005.06.12_15.07.24.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-115-letters/" target= "_blank">Letters read</a> on TWiP 115</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 115</h3> <p><span style="font-weight: 400;">This week's case is more challenging, but with a better outcome than last time. Thailand: 32 year old Thai man from southern coastal part of country, comes to ID hospital in Bangkok with two months of watery diarrhea. Rapid onset. Looks emaciated, protuberant belly. Ten times per day, has trouble flushing feces in toilet, floats. Eats normal fare, boat noodles, fish, rice, vegetables. Som tam - fish sauce from raw fish. Also with salted crab, not well cooked. No unusual past med history, healthy fisherman, no medication. Married with kids, everyone healthy. No bad habits. Monogamous. HIV negative. Liver, spleen not enlarged. Abdominal xray with contrast: loss of villi. Good appetite. No abdominal pain. Too weak to work. No vomiting.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 114: Plant potions perturb Plasmodium
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiP troika solve the case of the Female from the Bronx, and reveal how feeding on different plants affects mosquito capacity to transmit malaria.</p> <h3>Links for this episode:</h3> <ul> <li><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005773" target="_blank">Plant mediated effects</a> on malaria transmission (PLoS Path)</li> <li><a href= "http://www.mango.org/Mangos/media/Media/Images/Recipes/Beauty%20Images/Mango_varieties_5_bright_682x370.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-114-letters/" target= "_blank">Letters read</a> on TWiP 114</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>This episode <span style="font-weight: 400;">is also sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://www.drobo.com" target= "_blank">www.drobo.com</a> to learn more.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 114</h3> <p><span style="font-weight: 400;">12 year old boy brought to hospital ER by parents with severe headache, stiff neck, fever, decreased alertness. No rashes. Has been healthy with no prior medical problems. No one else in family is ill. In summer, boy has been engaged in usual summertime activities: soccer, swimming in warm freshwater, playing outside. Undergoes lumbar puncture for CSF: start on meningitis treatment. No surgeries, no allergies. Not on any meds. Lives with Mom, Dad, few brothers. No substance abuse. Not a geographically limited illness. Has had bug bites - lots of mosquito bites. Dogs around as well. Symptoms began a day or two before hospital visit. Eats whatever family eats, food is cooked. Exam: 39.4C, bp low, heart rate up, resp up, decreased responsiveness, stiff neck, looks ill. WBC elevated, neutrophil predominant, eosinopenia. CSF glucose low, cells increased, no bacteria, fungi, acid fast bacilli on stain. CT scan, diffuse swelling of brain. Doing poorly, not a good outcome.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 113: Flying pigs
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>Guest: <a href= "http://www.cumc.columbia.edu/dept/id/fellowship_fellows.html" target="_blank">Jason Zucker</a></p> <p>The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using <em>Eimeria tenella</em>.</p> <h3>Links for this episode:</h3> <ul> <li>Transgenic <em>Eimeria</em> as a <a href= "http://www.nature.com/articles/srep29379" target= "_blank">toxoplasma vaccine</a> (Sci Rep)</li> <li>Image shows cysticercus of <em>T. solium</em> in brain (Parasitic Diseases, 5th Ed)</li> <li><a href="http://www.microbe.tv/twip/twip-113-letters/" target= "_blank">Letters read</a> on TWiP 113</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 113</h3> <p><span style="font-weight: 400;">22 yo female comes to clinic in Bronx, reports one week of vaginal discharge and itching. Looks bad, yellowish. Sexually active with boyfriend. He has no symptoms. Some discomfort on urination. Healthy, no prior surgeries, no allergies. Mother with diabetes, father has high bp. Takes oral contraceptive pills. Not employed, lives with mother and sisters. Substance abuse: some on occasion, marijuana and alcohol, no i.v. No pets. Diet: lot of fast food. Physical exam: slightly heavy, normal but vaginal exam: discharge, thick, slight yellow light green color, no strong odor, some redness to vaginal walls, no changes to cervix. 2 weeks from last menstrual period. </span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 112: A NOD to a tricky helminth
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.</p> <p> </p> <p>Subscribe to TWiP (free) in <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a href= "http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target= "_blank">email</a></p> <h3>Links for this episode:</h3> <ul> <li>Helminth infection promotes <a href= "http://science.sciencemag.org/content/352/6285/608" target= "_blank">colonization resistance</a> (Science)</li> <li>NOD2 (Wikipedia)</li> <li>Image credit</li> <li><a href="http://www.microbe.tv/twip/twip-112-letters/" target= "_blank">Letters read</a> on TWiP 112</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>Become a <a href="http://microbe.tv/contribute" target= "_blank">patron</a> of TWiP.</p> <h3>Case Study for TWiP 112</h3> <p><span style="font-weight: 400;">A case here at CUMC, <span style="font-weight: 400;">59 yo male, past medical history of childhood polio, presents with worsening lower extremity weakness, bowel and urinary incontinence. 2 year before worsening back pain, weakness, could not work. Cannot walk up one flight of stairs since 1 month; 1 week prior to admission had fever, no headaches, diarrhea, cough, or any other symptoms. Splits time between Washington Heights and Mexico. Construction worker. Rural town in southern Mexico, 10 months of the year. Worked in the corn growing area. Has been exposed to bugs. Stopped working in cornfields 20 years ago. Has son and daughter, visits them. Lives with wife, stays in Mexico, she is fine. HIV negative. Eats home prepared foods, no dietary restrictions. Physical exam: not febrile, vital signs all good, neurological: upper strength good, weakness in hip flexors, ⅗; quadriceps, but ⅕ in lower extremities ⅖ in right. Sensory has decreased as well. Possibly spinal lesion. Labs: elevated glucose, ESR 33, CRP 2.2, whites 8, 30.6 hematocrit, guaiac negative. Imaging: MRI of spine shows normal vertebrae, T9/10 inflammation of spinal cord, mass lesion, compromise of canal. Brain MRI: hydrocephalus. Problem with recirculation of CSF. </span></span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 111: Bug bites
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiP trio solve the case of the bug bites all in a row, and talk about a secreted <em>Toxoplasma</em> protein that is central to the parasite's manipulation of host cells.</p> <p> </p> <p>Subscribe to TWiP (free) in <a href= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, <a href= "https://goo.gl/app/playmusic?ibi=com.google.PlayMusic&isi=691797987&ius=googleplaymusic&link=https://play.google.com/music/m/Ikfde3waxmlyfhqcip6g57s3a2a?t%3DThis_Week_in_Parasitism" target="_blank">Google Play Music</a>, by the <a href= "http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target= "_blank">email</a></p> <h3>Links for this episode:</h3> <ul> <li><a href= "https://blog.epa.gov/blog/2012/06/pigeon-mites-will-feed-on-sleeping-humans/" target="_blank">Pigeon mites</a> feed on humans at night (EPA)</li> <li><a href= "http://mbio.asm.org/content/7/1/e02231-15.abstract?sid=01bae455-18c6-4cee-b916-cb2918d3ca24" target="_blank">Secreted</a> <em>Toxoplasma</em> protein (mBio)</li> <li><a href= "https://www.google.com/imgres?imgurl=https://upload.wikimedia.org/wikipedia/commons/8/87/Bed_bug,_Cimex_lectularius.jpg&imgrefurl=https://en.wikipedia.org/wiki/Bed_bug&h=1122&w=1600&tbnid=HBcGTByostO1IM:&tbnh=140&tbnw=199&docid=hGqvCGYr5uWqrM&itg=1&usg=__m8p5bXaFc5HpgWlG_qScJCcNZOQ=" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-111-letters/" target= "_blank">Letters read</a> on TWiP 111</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/microbe" target="_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <h3>Case Study for TWiP 111</h3> <p><span style="font-weight: 400;">82 yo woman living in Washington Heights NYC 10 days of watery diarrhea, not smelly, does not float. Wakes her up at night. No fever, sweats at night. Losing some weight, appetite. No recent travel. Born in DR early 1930s, moved to US age 30. Sometimes goes back but not for several years. Springtime. Lives with extended family, only one sick. Eats whole assortment of cooked foods, rice, beans, fresh fruits. Drinks tap water. Not working. No pets. Stays mostly inside. History of reflux, high blood pressure, cognitive decline, diagnosed with temporal giant cell arteritis. Put on prednisone, doing better. Has had gall bladder removed. HIV negative. Extended family works in city, no taxi drivers. Belly uncomfortable for >week. Temp 38.1, BP 116/78, HR 105, breathing 12/min. Exam: looks ill, has diffusely tender abdomen, decreased bowel sounds. Liver, spleen not enlarged. Oriented. Has rash on abdomen: odd patchy distribution, looks like multiple thumbprints, front of belly, extending from umbilicus. White count 8, 78 polys, 14 lymphs, 4 mono, 1 eosinophil. Sodium 129, BUN 15, Creat 0.6. Urine histoplasma negative, TB test negative.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 110: Malaria at the Bronx Zoo
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.trichinella.org" target="_blank">Dickson Despommier</a>, and Daniel Griffin</p> <p>Guest: <a href="http://blog.wcs.org/photo/author/pcalle/" target="_blank">Paul Calle</a></p> <p>The TWiP trio visit the Bronx Zoo where Paul solves the case of the Four Year Old with Pulmonary Edema, and talks about his career as the Chief Veterinarian and Director of the Zoological Health program for the Wildlife Conservation Society.</p> <p> </p> <h3>Links for this episode:</h3> <ul> <li><a href= "http://bronxzoo.com/?gclid=Cj0KEQjwjoC6BRDXuvnw4Ym2y8MBEiQACA-jWe_nsF6hsVqXXyRYAlydhc8mjJ9XOr-UIVL881IocRQaAqxg8P8HAQ" target="_blank">Bronx Zoo</a></li> <li><a href="https://en.wikipedia.org/wiki/Avian_malaria" target= "_blank">Avian malaria</a> (Wikipedia)</li> <li><a href="http://www.microbe.tv/twip/twip-110-letters/" target= "_blank">Letters read</a> on TWiP 110</li> <li>Video of this episode at <a href="https://youtu.be/Pn9LTJC2cXs" target="_blank">YouTube</a></li> </ul> <p>This episode is sponsored by CuriosityStream, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.</span></p> <h3>Case Study for TWiP 110</h3> <p>This week's case involves humans. Young woman, 40s, concerned about bug bites. Several weeks ago her 13 year old daughter woke up in morning, reported bug bites. Several small, red, raised itchy areas, 3-4 in a line, just above belt line. They go on vacation in Europe, no problems. Upon return, several weeks later the Mother woke up with a similar pattern. Then second daughter has the same problem. Family lives in NY metropolitan area, which is an epicenter for this problem. Always on trunk, not on arms or legs. No travel before the first daughter's bug bites. Husband does not report any problems. Family spends a lot of time outdoors, live in suburban wooden area.</p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 109: Blame it on Mother
<p>Hosts: <a href= "http://en.wikipedia.org/wiki/Vincent_Racaniello" target= "_blank">Vincent Racaniello </a>and Daniel Griffin</p> <p>Guest: Paul</p> <p>Daniel and Vincent solve the case of the Truck Driver from India, discuss why parasites resistant to an antimalarial drug are not transmitted by mosquitoes, and introduce Paul who presents a new case study.</p> <p> </p> <h3>Links for this episode:</h3> <ul> <li>Atovaquone resistant parasites <a href= "http://www.ncbi.nlm.nih.gov/pubmed/27081071" target="_blank">not transmitted by mosquitoes</a> (Science)</li> <li>Image credit</li> <li><a href="http://www.microbe.tv/twip/twip-109-letters/" target= "_blank">Letters read</a> on TWiP 109</li> </ul> <p>This episode is sponsored by <a href= "http://curiositystream.com/microbe" target= "_blank">CuriosityStream</a>, <span style= "font-weight: 400;">a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code MICROBE​.</span></p> <p>Send your case diagnosis, questions and comments to <a href="mailto:twip@microbe.tv" target= "_blank">twip@microbe.tv</a></p>
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TWiP 108: B1 cells and Leishmania, insider traitors
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The case of the Man from Assam is solved, and phagocytosis of Leishmania by B-1 cells is brought to you by the <span style="font-weight: 400;">Three Twipeteers</span> on this episode of TWiP.</p> <p> </p> <p>Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, <a href="https://goo.gl/app/playmusic?ibi=com.google.PlayMusic&isi=691797987&ius=googleplaymusic&link=https://play.google.com/music/m/Ikfde3waxmlyfhqcip6g57s3a2a?t%3DThis_Week_in_Parasitism" target="_blank">Google Play Music</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <h3>Links for this episode:</h3> <ul> <li><span style="font-weight: 400;"><a href="http://www.inbios.com/cms/file/900003_9%20%20CE%20Marked%20Kalazar%20Detect%20Rapid%20Test.pdf" target="_blank">Kalazar detect</a> (pdf)</span></li> <li><span style="font-weight: 400;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/27084328" target="_blank">Phagocytosis</a> of <em>Leishmania</em> promastigotes by B-1 cells (Parasite Immunol)</span></li> <li>Image credit</li> <li><a href="http://www.microbe.tv/twip/twip-108-letters/" target="_blank">Letters read</a> on TWiP 108</li> </ul> <p>This episode is sponsored by <a href="http://bit.ly/agarart2016" target="_blank">ASM Agar Art Contest</a> and <a href="http://www.asm.org/asmmicrobe" target="_blank">ASM Microbe 2016</a></p> <h3>Case study for TWiP 108</h3> <p><span style="font-weight: 400;">Todays case is a 26 yo male longhaul truck driver from northern tiger country of India. Comes into hospital at end of rainy season with 6 days of fever, chills, muscle aches, small loose stools, vomiting, trouble breathing, cough, decreased urine output. Lives in mud hut with coconut leaf roof. No one else in family  is sick (wife, two children). Significant animal and insect exposure (dogs, cows, monkeys). Got sick after coming home from a trip up north. No significant medical probs, no surgery. Really sick. Pain everywhere. Occasionally drinks palm wine. Some yellowing of eyes. Has lost a little weight. Ketonic breath. Exam: 39 fever, bp 100/71, 126 heart rate, 24 resp rate. Looks distressed, not fully sharp. Nothing focal on lung exam. Belly tender, esp upper right, spleen enlarged. Liver is tender but not enlarged. Some labs: bun elevated 102, creatinine elevated, Hg decreased 11, platelets 9000 (down), white count 10.3 no eosinophils. LDH 8000 AST/ALT normal, bilirubin 21. Never been this sick.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 107: Parasites leave a bad taste in my gut
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPtastic trio solves the case of the Surfer from Switzerland, and reveal how taste-chemosensory tuft cells in the gut regulate immune responses to parasites.</p> <p>Links for this episode:</p> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26847546" target="_blank">Taste-chemosensory cells</a> and parasite gut immunity (Science)</li> <li><a href="http://pinkava.asu.edu/starcentral/microscope/portal.php?pagetitle=assetfactsheet&imageid=23265" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-107-letters/" target="_blank">Letters read</a> on TWiP 107</li> </ul> <p>This episode is sponsored by <a href="http://bit.ly/agarart2016" target="_blank">ASM Agar Art Contest</a> and <a href="http://www.asm.org/asmmicrobe" target="_blank">ASM Microbe 2016</a></p> <h3> Case study for TWiP 107</h3> <p><span style="font-weight: 400;">Todays case is a fun case about a 45 year old gentleman from Assam India, with sixteen years of fever, abdominal pain, darkening of skin, yellowing of eyes. Farmer, does not have much energy. Works barefoot in fields. Fever occurs every other day. Prior medical problems, nothing out of the ordinary. No surgeries, no meds, has never seen physician. Married, kids, no extramarital affairs, HIV negative, eats mostly cooked vegetables. Lives in concrete house, no screens, mosquito netting. Other people in area have similar problems. Water comes from pump, fill plastic jugs. Been in Assam sick his whole life, finally came to regional med center for evaluation. Underweight. No pets. Dogs around, avoids dogs. Cows, monkeys are around. Fair appetite. Exam: febrile, in face can see darkening which is increasing, also extremities. Whites of eyes are yellow (jaundiced). Striking is has a very large liver, spleen. Elevated bilirubin. Some increased liver enzymes. No physical scarring or lesions.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 106: Trematode stormtroopers in snail wars
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiP triumvirate solves the case of the Missionary in Kenya, and review the finding of a soldier caste in flatworms that parasitize snails.</p> <h3>Links for this episode:</h3> <ul> <li><a href="http://www.bioone.org/doi/10.1645/15-853" target="_blank">Social organization</a> in parasitic flatworms (J Parasitol)</li> <li><a href="https://en.wikipedia.org/wiki/Biomphalaria_glabrata#/media/File:Biomphalaria_glabrata.jpg" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-106-letters/" target="_blank">Letters read</a> on TWiP 106</li> </ul> <p>This episode is sponsored by <a href="http://bit.ly/agarart2016" target="_blank">ASM Agar Art Contest</a></p> <h3> Case study for TWiP 106</h3> <p>This week's case comes from <span style="font-weight: 400;">an ophthalmologist colleague Florian in Switzerland. Swiss female, early 20s, returns after surfing vacation in northern Africa. Accommodations were rustic, lots of animal and insect exposure, right on the beach. No screens. Had loose stools there, now left eye is bothering her, eyelid swollen, eye red. This happened after return. Thinks she has seen things moving around in her eye. Opthalmologist gave eyedrops, now looking for second opinion. Healthy, no med/surg/allergies, no meds, student lives alone, occasional alcohol. No AIDS. Surfing in Morocco. Lots of insect bites. Little tiny things moving around in eye, on surface when she looks in mirror. All blood work was negative. Florian inspects her eye, surprised to see several tiny mobile objects, headed towards lacrymal ducts. Is able to grab one, about 1 mm long, plucks three off.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 105: Survival of the fattest
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity.</p> <h3>Links for this episode:</h3> <ul> <li><em>Trichinella</em> life cycle (<a href="http://www.microbe.tv/twip/wp-content/uploads/sites/3/2016/03/trichinellaspiralis.pdf" target="_blank">pdf</a>)</li> <li>When parasites are <a href="http://www.ncbi.nlm.nih.gov/pubmed/26938743" target="_blank">good for health</a> (PLoS Path)</li> <li><a href="http://astore.amazon.com/virologyws-20/detail/0521186374" target="_blank"><em>The Origin of AIDS</em></a> by Jacques Pepin</li> <li><a href="http://www.microbe.tv/twip/twip-105-letters/" target="_blank">Letters read</a> on TWiP 105</li> </ul> <h3> Case study for TWiP 105</h3> <p>This week's case involves a <span style="font-weight: 400;">32 yo male with several concerns. Spent 6 weeks doing religious missionary work in Kenya, performed baptisms in Lake Victoria.Waist deep in water, no shoes. Took malaria drugs, ate lots of interesting foods: cichlids, ugali, corn based food, flavored with greens; stew with some sort of meat, beef and goat. Five weeks after return developed rash with fever, shortness of breath. Three of four friends who were with him in Kenya reported similar symptoms. The fourth who did not get sick did not go in water, nor did he eat very much. No medical/surgical history, no drugs. Had some sexual activity while there. Elevated white count, 70% eosinophils. Chest CT shows nodules in lungs. Doc told him, allergy, you will be fine. The water he went into is near a village, there are rodents nearby, and a runoff.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 104: La maladie du sommeil
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>Guest: <a href="https://muhc.ca/newsroom/node/42975/" target="_blank">Michael Libman</a></p> <p>Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, and discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis.</p> <h3>Links for this episode:</h3> <ul> <li><em>T. brucei</em> life cycle (<a href="http://www.microbe.tv/twip/wp-content/uploads/sites/3/2016/02/tbgambiense.pdf" target="_blank">pdf</a>)</li> <li><a href="http://www.sciencedirect.com/science/article/pii/S0171298515300358" target="_blank">Natural and induced antibodies</a> in echinococcosis (Immunobiol)</li> <li>The <a href="http://compgen.unc.edu/wp/?page_id=99" target="_blank">collaborative cross</a></li> <li><a href="http://www.microbe.tv/twip/twip-104-letters/" target="_blank">Letters read</a> on TWiP 104</li> </ul> <h3> Case study for TWiP 104</h3> <p>This week's case involves a y<span style="font-weight: 400;">oung man in his thirties, admitted in hospital in Anchorage AK in early June. Chief complaint, severe muscle pain and tenderness. Usually healthy guy, 1 week ago had bad case of diarrhea with belly pain and vomiting, lasted a full week. Now has fever. Concerned because wife now is having diarrhea. Unremarkable history, unknown family history. HIV negative. All childhood vaccinations. Does not eat raw meat. No meds, does seasonal work, social drinker. Came back from successful hunt, got a black bear. Dressed in field, cooked at home really well. Wife also ate bear meat. Bear meat is in freezer. No vegetables. Also eats salmon which he caught the previous season, then frozen. Drinks water from the stream when he hunts. Physical exam: hot, 38.5, bp 115/75, pulse 105, breathing comfortably. Anxious, swelling around both eyes. Sclera not noted. Labs: WBC elevated 14,000, 30% eosinophils; chemistries fine; muscle enzymes LDH, CK elevated.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 103: Scroll down, please
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>Guest: <a href="https://muhc.ca/newsroom/node/42975/" target="_blank">Michael Libman</a></p> <p>The TWiP-scholars solve the case of the Housewife from Kolkata, discuss mutations in the IL17 gene associated with cerebral malaria, and hear a case presentation from guest Michael Libman.</p> <p> </p> <h3>Links for this episode:</h3> <ul> <li>IL-17 mutations and risk of <a href="http://iai.asm.org/content/84/2/590.full" target="_blank">cerebral malaria</a> (Inf and Imm)</li> <li><a href="http://www.cdc.gov/parasites/echinococcosis/" target="_blank">Echinococcosis</a> (CDC)</li> <li><em>Echinococcus</em> <a href="http://www.microbe.tv/twip/wp-content/uploads/sites/3/2016/02/echinococcusgran.pdf" target="_blank">life cycle</a> (pdf)</li> <li><a href="http://www.microbe.tv/twip/twip-103-letters/" target="_blank">Letters read</a> on TWiP 103</li> </ul> <h3> Case study for TWiP 103</h3> <p>This week's case concerns a <span style="font-weight: 400;">42 yo male, refugee in Canada, from DRC, former Zaire, where there is unending civil war. Upper middle class, professor of French at university. Had been imprisoned, tortured, lived in jungle for a few years, reached refugee camp in Tanzania, moved to Canada. Came to health care system 15 months after arrived. Was sent to psych, unstable emotionally, delusions, hallucinations, depression, post traumatic issues. Was under psych care for ~1 yr, did not improve, became worse. Sent to hospital. History: talked about having minor injury, hurt lower back, pain there bothering him. Some anemia (normochromic), basic hem/chem/urine/liver nothing remarkable. Physical exam, nothing remarkable. HIV negative. Some evidence for chronic inflammatory condition: sed rate 60 (elevated), had diffuse increase in IgG, IgM. Developed some low level autoantibodies; anti-nuclear, p-anka, anti-neutrophil cytoplasmic antibodies. Slightly elevated fever for a few days, then few days or week with no fever. No eosinophilia. Radiology: on CT did have some mediastinal, aortic, axillae, lymphadenopathy. Prob screened in Africa for malaria and treated; prob also got ivermectin. Also got head MRI: not completely normal, classic nonspecific midbrain abnormality. Diffuse mild edema. Weight loss remarkable. No visual problems.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 102: Nursing eosinophils
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiPyzoites solve the case of the Uncommon Parasite, and discuss the role of eosinophils in promoting the growth of <em>Trichinella</em> in skeletal muscle.</p> <p> </p> <h3>Links for this episode:</h3> <ul> <li>Eosinophils and IL-4 support <a href="http://www.ncbi.nlm.nih.gov/pubmed/26720604" target="_blank">nematode growth</a> (PLoS Path)</li> <li><a href="http://www.cdc.gov/parasites/balantidium/" target="_blank">Balantidiasis</a> (CDC)</li> <li><a href="http://www.microbe.tv/twip/twip-102-letters/" target="_blank">Letters read</a> on TWiP 102</li> </ul> <h3> Case study for TWiP 102</h3> <p>This week's case <span style="font-weight: 400;">involves a 24 yo housewife, from a village outside of Calcutta. Comes into a tertiary care hosp, 6 months coughing up blood, fever, no weight loss. Drinks rainwater, milks her cow. Dogs everywhere, no livestock except cows. Eats meat, well cooked. No extramarital encounters. Husband well. 4 children. Cistern for drinking water is covered.  No health issues. Reports salty, clear mucus. No blood in stool, no changes in stool. Exam: looks healthy, lungs clear. Lab tests: White count of 9000, 12% eosinophils (elevated). So she has eosinophilia. Chest X-ray and CT: lesion on left side in xray. CT: shows 4 cm cavity, with air pocket on left side, mid-lung. HIV negative. Dusty soil, birds.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 101: Is it round or is it flat?
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The doctors TWiP solve the case of the Woman with White Worms, and explain the role of a secreted growth factor from a carcinogenic parasite in wound healing and angiogenesis.</p> <p> </p> <h3>Links for this episode:</h3> <ul> <li>Wound healing <a href="http://www.ncbi.nlm.nih.gov/pubmed/26485648" target="_blank">growth factor</a> from carcinogenic parasite (PLoS Path)</li> <li><em>Opisthorchis</em> (CDC)</li> <li><em>Opisthorchis</em> <a href="http://www.cdc.gov/parasites/opisthorchis/biology.html" target="_blank">life cycle</a> (CDC)</li> <li><a href="https://en.wikipedia.org/wiki/Opisthorchis_viverrini" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-101-letters/" target="_blank">Letters read</a> on TWiP 101</li> </ul> <h3>Listener Pick</h3> <p><strong>Ramon</strong> - <a href="http://www.livescience.com/53303-ancient-rome-infested-with-parasites.html" target="_blank">Ancient Rome was infested with parasites</a></p> <h3>Case study for TWiP 101</h3> <p>This week's case <span style="font-weight: 400;">involves an uncommon parasite. Young girl, <10 y, brought in by parents from rural area to regional hospital with fever, diarrhea for 2 weeks. No blood in stool. Parents: few weeks prior to problems, young girls went with family on wild pig hunting trip. With guns. Girl did consume pig on trip, all meat was very well cooked. Was involved with preparation of meat with Mother only. No one else got sick. No surgery, no allergies. Both parents have diabetes. Has four brothers. Some weight loss. This is outside the US. Physical exam: low grade fever, diffuse mild abdominal discomfort, slight microcytic anemia, size of cells is slightly smaller than normal. WBC: normal, except no eosinophils. Blood cultures negative. Stool examination is where we get our answer.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 100: Driving past a milestone
<p>Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p>The TWiP trifecta solves the case of the Woman from Bolivia with Belly Pain, and discuss a method for population modification of malaria mosquitoes using a Cas9-mediated driver gene.</p> <h3>Links for this episode:</h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26598698" target="_blank">Cas9-mediated drive</a> for population modification of malaria mosquito (PNAS)</li> <li><a href="http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf" target="_blank">FAQ: Gene drives</a> (pdf)</li> <li><a href="http://wyss.harvard.edu/staticfiles/newsroom/pressreleases/Gene%20drives%20FAQ%20FINAL.pdf" target="_blank">Image credit</a></li> <li><a href="http://www.microbe.tv/twip/twip-100-letters/" target="_blank">Letters read</a> on TWiP 100</li> </ul> <h3>Case study for TWiP 100</h3> <p>This week's case is a <span style="font-weight: 400;">27 yo female, native NY, referred to outpatient at CU after seeing OBGYN, told had seen worms in stool and underwear. Inch or two in length, pale white, round, moving, 2-3 weeks of constant abdominal bloating. Sexually active. No particular diet. Travel: works for NGO, refugee camp in Ethiopian-Sudan border, southern Sudan. Last visit month ago. Noticed worms when she got back from last trip. Eats what local people eat. Raw food popular there: kitfo, raw steak tartare, with melted butter. Made from local beef. Did not take malaria prophylaxis, did not avoid local water, does wear sandals. College graduate. Nothing remarkable in family. CBC, liver, metabolic: all normal. Stool not normal: loose, no mucus or blood.</span></p> <p>Send your diagnosis to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@microbe.tv" target="_blank">twip@microbe.tv</a></p>
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TWiP 99: You get your polar bear from your nana
<p>The TWiP trifecta solves the case of the Professor Who Went to Brazil, and discuss an amazing case of a tapeworm that turned into a tumor in an AIDS patient.</p> <p>Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p> </p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li>Do young doctors need <a href="http://www.slate.com/blogs/the_drift/2015/12/02/young_doctors_needed_more_sleep_but_the_plan_for_them_to_get_it_might_have.html" target="_blank">more sleep?</a> (Slate)</li> <li><a href="http://www.nejm.org/doi/full/10.1056/NEJMoa1505892#t=articleTop" target="_blank"><em>H. nana</em> tumor</a> in AIDS patient (NEJM)</li> <li><a href="http://www.cdc.gov/parasites/hymenolepis/faqs.html" target="_blank">Hymenolepiasis</a> (CDC)</li> <li><em>H. nana</em> <a href="https://en.wikipedia.org/wiki/Hymenolepis_nana#/media/File:H_nana_LifeCycle.gif" target="_blank"><em>lifecycle</em></a> (CDC/Wikipedia)</li> <li><a href="https://en.wikipedia.org/wiki/Hymenolepis_nana#/media/File:H_nana_adultF.JPG" target="_blank">Image credit</a></li> <li><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/2036-tip-99-letters" target="_blank">Letters read</a> on TWiP 99</li> </ul> <p><span style="color: #bc0101; font-size: 1.2em; font-weight: bold;">Case study for TWiP 99</span></p> <p>This week's case is a 53 yo woman visiting family in US, comes in with intense belly pain, right upper part of belly. Has become strict vegetarian after having breast cancer, on raw vegetable diet (carrots, collect plants in local markets). From Bolivia. Lives in agricultural area, avoids sheep, fearful of dogs. Housekeeper. Married, lives with husband. Noticed pain when came to US. Breast cancer: localized, removed lesion, no therapy, months ago. No allergies, family healthy. No insect bites, lives in concrete house. Physical exam: not febrile, right upper quadrant is very tender, some liver enlargement. CBC: 10,000 white count, mostly eosinophils, liver function: AST, ALT, AlkPhos all normal. Neuro exam: normal. Five months before this diet, she did have normal diet. Some meat, drank milk.</p> <p>Send your diagnosis to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p>Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p>TWiP is a MicrobeTV production</p>
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TWiP 98: Resistance is not futile
<p>The TWiP-lets reveal <em>Balamuthia</em> infection in the Children from Peru, and discuss resistance to pyrethroids revealed by RNA sequencing of <em>Anopheles</em> mosquitoes.</p> <p>Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li><a href="http://www.cdc.gov/parasites/balamuthia/gen_info/faqs.html" target="_blank"><em>Balamuthia</em></a> (CDC)</li> <li>Pyrethroid <a href="http://www.ncbi.nlm.nih.gov/pubmed/26381877" target="_blank">resistance</a> in <em>Anopheles</em> (Parasit Vectors)</li> <li>Voltage-gated <a href="http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=82" target="_blank">sodium channels</a></li> <li><a href="https://en.wikipedia.org/wiki/Pyrethroid" target="_blank">Pyrethroid</a> (Wikipedia)</li> <li><a href="https://commons.wikimedia.org/wiki/File:Balamuthiatrop.jpg" target="_blank">Image credit</a></li> <li><a href="podcasts/this-week-in-parasitism/parasitism-letters/2016-twip-98-letters" target="_blank">Letters read</a> on TWiP 98</li> </ul> <p><span style="color: #bc0101; font-size: 1.2em; font-weight: bold;">Case study for TWiP 98</span></p> <p>This week's case is a Professor clinician, teacher, researcher.  In his 50s, he presents with lesion on big toe, anterior portion, tip, nodular. No surrounding redness, area is itchy. Has a small central black area the size of pencil tip, concerned because feels is getting larger over last week. Spooky. Travels, last in Brasil, had been for a few weeks, noticed toe issue a week after returned. Spent time on beach, but wore flip flops. Different types of beaches, crowded and not crowded. Went with wife. Healthy man, no prior medical problems.</p> <p>Send your diagnosis to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p>Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank">email</a> </p>
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TWiP 97: The seven year itch
<p>The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with <em>Plasmodium</em>.</p> <p>Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p> </p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2015/" target="_blank">Parasite</a> Nobel Prizes 2015</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/15550944" target="_blank">Ivermectin</a> story (Nat Rev Micro)</li> <li>Ivermectin <a href="http://www.ncbi.nlm.nih.gov/pubmed/1279355" target="_blank">target</a> (Brain Res)</li> <li>Gut microbiota and <a href="http://www.ncbi.nlm.nih.gov/pubmed/25480293" target="_blank"><em>Plasmodium</em> protection</a> (Cell)</li> <li><a href="http://www.virology.ws/2009/10/06/natural-antibody-protects-against-viral-infection/" target="_blank">Natural antibody</a> (virology blog)</li> <li><a href="https://en.wikipedia.org/wiki/Sarcoptes_scabiei#/media/File:Sarcoptes_scabei_2.jpg" target="_blank">Image credit</a></li> <li>Letters read on TWiP 97</li> </ul> <p><span style="color: #bc0101; font-size: 1.2em; font-weight: bold;">Case study for TWiP 97</span></p> <p>Daniel has two cases this week. Two people with similar presentations. A 12 yo girl in Peru presented for care with painless dark brown area on right knee. Has brothers and sisters, often play together. No trauma, but area is expanding. Months later develops cognitive changes. Second case is a 5 yo boy from the coastal region of Peru brought in by Mother, has red swollen area on face. Mom says while playing scratched nose, swelling right cheek, eye, nasal obstruction, no response to antibiotics. MRI of both show infiltrating process. Girl, left side of brain, middle cerebral artery territory. Boy in frontal region, midline area. Thus both skin lesions associated with infiltrating process in brain. Came into clinic months after lesions started, and lesions still present.</p> <p>Send your diagnosis to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p>Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p> </p>
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TWiP 96: Salivary pharmacopeia
<p>The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis.</p> <p>Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <p> </p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/25596303" target="_blank">Sandfly exposure</a> and risk of cutaneous leishmaniasis (J Inf Dis)</li> <li><a href="podcasts/this-week-in-parasitism/712-twip-14-leishmania" target="_blank">TWiP 14: <em>Leishmania</em></a></li> <li>Image is <em>L. longipalpis</em> (<a href="https://en.wikipedia.org/wiki/Lutzomyia" target="_blank">credit</a>)</li> <li><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/2000-trip96-letters" target="_blank">Letters read</a> on TWiP 96</li> </ul> <p><span style="color: #bc0101; font-size: 1.2em; font-weight: bold;">Case study for TWiP 96</span></p> <p>Daniel's patient for this week is male patient referred for consultation by OB-GYN: his wife is pregnant, has been admitted and is about the give birth. It is her first pregnancy. There are concerns about the husband's skin problem and whether it is a threat to his pregnant wife. No lesions on woman, husband recently developed itchy skin problem on his hands. Bilateral. Small papules on webs of fingers, brown lines, blood clots at ends, has clearly scratched the lesions. Skin between fingers is involved. Travels, often stays in cheap hotels. Beds not clean. Last trip 1 month before symptoms.  Midwest travel. Family history of heart disease. Sales occupation. No animal exposure. Travels to medium to large cities. </p> <p>Send your diagnosis to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p>Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p>Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p> </p>
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TWiP 95: Arsenic and Leishmania
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for <em>Leishmania</em> infections.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: #4da7d4;" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li><a style="color: #4da7d4;" href="podcasts/this-week-in-parasitism/782-twip-17-entamoeba-histolytica" target="_blank">TWiP 17: <em>Entamoeba histolytica</em></a></li> <li><a style="color: #4da7d4;" href="http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003518" target="_blank">Arsenic exposure</a> and <em>Leishmania</em> treatment outcomes (PLoS NTD)</li> <li><a style="color: #4da7d4;" href="podcasts/this-week-in-parasitism/712-twip-14-leishmania" target="_blank">TWiP 14: <em>Leishmania</em></a></li> <li><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1984-twip-95-letters" target="_blank">Letters read</a> on TWiP 95</li> </ul> <p style="height: 5.36932px;">This episode is sponsored by <a style="color: #4da7d4;" href="http://bit.ly/swpionline15" target="_blank">ASMGAP</a>.</p> <h3 style="color: #bc0101;">Case study for TWiP 95</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Daniel's patient for this week is a 28 yo single female, returns from beach vacation with new boyfriend. Two weeks in Central America (Belize). Often found secluded beaches. Good health, noticed upon her return had small nodules/papules on front of thighs. Thought were insect bites, became very itchy. Noticed serpiginous red lines forming, radiating out from bumps. Felt things moving in her skin. Benadryl did not help. Daniel say something similar occurs in Lima. Healthy, no allergies, surgeries, no relevant family history, using barrier contraception, sexually active. Only drinks alcohol socially. Boyfriend did not report symptoms. She did lie on sand, used thin fabric. Stayed in hotel. There were wild dogs on beach. During her stay she ate ceviche. No intestinal symptoms.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your diagnosis to <a style="color: #4da7d4;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: #4da7d4;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: #4da7d4;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: #4da7d4;" href="http://eepurl.com/Gcw59" target="_blank">email</a> </p>
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TWiP 94: Loa hanging fruit
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel solve the case about the man from El Salvador, discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Targeting filarial <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25657255" target="_blank">tyrosine kinases</a> (J Inf Dis)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Onchocerciasis on <a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/archives/904-twip-24-onchocerca-volvulus-a-vector-borne-filarial-nematode" target="_blank">TWiP 24</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Filariasis on TWiP <a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/archives/926-twip-25-wuchereria-bancrofti" target="_blank">TWiP 25</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image shows c-abl kinase bound to imatinib (red)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="https://commons.wikimedia.org/wiki/File:Bcr_abl_STI_1IEP.png" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://insects.about.com/od/ticksmites/f/What-Good-Are-Ticks.htm" target="_blank">What good are ticks?</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.765625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 94</li> </ul> <h3 style="color: #bc0101;">Case study for TWiP 94</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Daniel's patient was seen in the clinic. He is a 33 yo chinese male, from Chinatown NYC, for several months on and off has had watery diarrhea, headaches. Tried reflexology, chiropractic therapy, with no results. Has traveled quite a bit, been in Chile (was there a few months before). Came to US when young. Grew up in the US. In Chile, has had many sexual partners, >50, of both sexes, also has done many drugs. Two years ago was diagnosed with chronic HIV, CD4 count 685, on ARVs triple therapy, virus loads are well controlled. Has had syphilis, nose job, no medication allergies. Lives with family. On exam, afebrile, looks well. Symptom onset a few months after last Chile visit. Is an addventurous eater.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> Send your diagnosis to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 93: A fishy tale unfolds
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel solve their fishy tale, and present a new case study for your consumption.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="height: 1.359375px;">Freezing and the <a style="color: rgb(77, 167, 212);" href="http://cid.oxfordjournals.org/content/60/9/e43.full" target="_blank">quality of sushi</a> (Clin Inf Dis)</li> <li style="height: 1.359375px;">Anisakis <a style="color: rgb(77, 167, 212);" href="http://www.cdc.gov/parasites/anisakiasis/biology.html" target="_blank">biology</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5.4375px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.cdc.gov/parasites/anisakiasis/biology.html" target="_blank">Image credit</a></li> <li style="height: 1.359375px;"><span style="line-height: 1.4em;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1956" target="_blank">Letters read</a> </span><span style="line-height: 1.4em;">on TWiP 93</span></li> </ul> <h3 style="color: #bc0101;">Case study for TWiP 92</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">April 2015 a 177 lb 5ft10in 39 yo man seen as outpatient in ID clinic, reports 2 y ago had issues with constipation on and off; throat hurts; feels closing when lies down. For several years has had skin irritation on upper chest and arms. Tried to donate blood, was rejected, told to see doctor.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Emigrated to US from El Salvador 2002, married, reports no extramarital sex, smokes 2-3 cigs/day, now quit; had drinking issue in past, no more; was agricultural worker in rural part of El Salvador; has history of asthma, on a number of medicines, including steriod nasal spray, inhaler, no visual problems, healthy appearing, not allergic to medicines. Family history: mother heart attack and diabetes; father peptic ulcer disease.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your diagnosis to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 92: Kleptohaemodeipnonism
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 8.67897701263428px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Ascaris on <a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/archives/854-twip-21-the-giant-intestinal-worm-ascaris-lumbricoides" target="_blank">TWiP 21</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 8.67897701263428px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><em>Ascaris lumbricoides</em> life cycle (<a style="color: rgb(77, 167, 212);" href="images/stories/twip/a_lumbricoides.jpg" target="_blank">jpg</a>)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 8.67897701263428px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Child with distended abdomen due to Ascaris (<a style="color: rgb(77, 167, 212);" href="images/stories/twip/ascaris_bolus.jpg" target="_blank">jpg</a>)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 8.67897701263428px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/26085582" target="_blank">Bottlenecks</a> and Chagas disease (Proc Biol Soc)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 8.67897701263428px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><span style="line-height: 1.4em;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1938" target="_blank">Letters read</a> </span><span style="line-height: 1.4em; background-color: initial;">on TWiP 92</span></li> </ul> <h3 style="color: #bc0101;">Case study for TWiP 92</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">A 20 yo Japanese female student went to the emergency room with severe abdominal pain. nausea, had vomited. Had just enjoyed homemade sushi an hour or two previuosly. She prepared the sushi: rice, salmon, tuna rolls. Salmon was local, caught by boyfriend. Tuna from store, sushi grade. No past medical history, mother with anemia. Takes oral contraceptives. No toxic habits. No travel. Monogamous. Temp 100.2, bp 140/90, hr high 90s, breathing upper teens. Physical exam normal except appears distressed in pain, belly extended, tender in left upper quadrant. Friends ate sushi but no one else got sick. All guests ate both types of fish.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your diagnosis to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 91: Born to deform
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of <em>Plasmodium falciparum</em>, and introduce a new case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.09943151473999px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Malaria life cycle (<a style="color: rgb(77, 167, 212);" href="images/stories/twip/falciparum_cycle.jpg" target="_blank">jpg</a>)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.09943151473999px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">cAMP regulates gametocyte infected <a style="color: rgb(77, 167, 212);" href="http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004815" target="_blank">erythrocyte deformability</a> (PLoS Path)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.09943151473999px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><em>P. falciparum</em> in <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/24335496" target="_blank">bone marrow</a> (Blood)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.09943151473999px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004815" target="_blank">Image credit</a></li> <li style="height: 5.09943151473999px;"><span style="line-height: 1.4em;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1928-twip-91-letters" target="_blank">Letters read</a> </span><span style="line-height: 1.4em; background-color: initial;">on TWiP 91</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 90: A carbuncle is a large furuncle
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of <em>Plasmodium falciparum</em>, and introduce a new case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.19602274894714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Dermatobia_hominis" target="_blank"><em>Dermatobia hominis</em></a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.19602274894714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><em>Plasmodium falciparum</em> <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25954012" target="_blank">erythrocyte invasion</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.19602274894714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Plasmodium <a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/archives/651-twip-10-plasmodium-life-cycle" target="_blank">life cycle</a> (TWiP #10)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.19602274894714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><span style="line-height: 1.4em;"><a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/parasitism-letters/1911-twip-90-letters" target="_blank">Letters read</a> </span><span style="line-height: 1.4em; background-color: initial;">on TWiP 90</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 89: Day TWiPers
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.95170450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Neurocysticercosis (<a style="color: rgb(77, 167, 212);" href="index.php?option=com_content&view=article&id=615:twip-6-tapeworms-the-long-and-short-of-it&catid=99:this-week-in-parasitism&Itemid=259" target="_blank">TWiP 6</a>)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.10511350631714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.cdc.gov/parasites/cysticercosis/" target="_blank">Cysticercosis</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.10511350631714px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Sarah Lane's <a style="color: rgb(77, 167, 212);" href="http://www.sarahlane.com/archive/2009/11/1/sarah-the-goddess-of-brain-tumors-part-2.html" target="_blank">neurocysticercosis</a></li> <li style="height: 5.95170450210571px;"><span style="line-height: 1.4em;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1902" target="_blank">Letters read</a> </span>on TWiP 89</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 88: French foreign lesion
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite <em>Theileria</em> transforms its host cells via a cellular proto-oncogene.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.95170450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/archives/712-twip-14-leishmania" target="_blank">Leishmania</a> (TWiP #14)</li> <li style="height: 5.95170450210571px;">Transformation by a <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25624101" target="_blank">prolyl isomerase</a> (Nature)</li> <li style="height: 5.95170450210571px;"><a style="color: rgb(77, 167, 212);" href="http://www.theileria.org/ahdw/index.htm" target="_blank">Theileria.org</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.95170450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Prolyl_isomerase" target="_blank">Prolyl isomerase</a> (Wikipedia)</li> <li style="height: 5.95170450210571px;">Image from <a style="color: rgb(77, 167, 212);" href="https://youtu.be/VUFxLOhsfyk" target="_blank">Transformation & Oncogenesis</a></li> <li style="height: 5.95170450210571px;"><span style="line-height: 1.4em;">Letters read </span>on TWiP 88</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 87: Stumped by pinworm
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and present another mystery for your solving.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #31c601; text-decoration: none;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 6.265625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.cdc.gov/parasites/pinworm/gen_info/faqs.html" target="_blank">Pinworm</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 6.265625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="podcasts/this-week-in-parasitism/archives/813-twip-19-enterobius-vermicularis-the-pinworm">Pinworm on TWiP #19</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 6.265625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Dynamics of <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/25814582" target="_blank">antigenic variation</a> in <em>T. brucei</em> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 6.265625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://commons.wikimedia.org/wiki/File:TrypanosomaBrucei_ProcyclicTrypomastigote_SEM.jpg" target="_blank">Image credit</a></li> <li style="height: 6.265625px;"><span style="line-height: 1.4em;"><a href="http://www.microbeworld.org/component/content/article?id=1886" target="_blank">Letters read</a> </span>on TWiP 87</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 86: Worms Loa the immune response to mycobacteria
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.92045450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.jimmunol.org/content/194/6/2706" target="_blank">Filarial infection</a> modulate immune response (J Immunol)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.92045450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Memory_T_cell" target="_blank">Memory T cells</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.92045450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Image: <em>Loa loa</em> microfilaria</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.92045450210571px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><span style="line-height: 1.4em; background-color: initial;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1872-twip-86-letters" target="_blank">Letters read</a> </span>on TWiP 86</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 85: Channeling tryps
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Human trypanolytic factor <a style="color: rgb(77, 167, 212);" href="http://www.pnas.org/content/112/9/2894.abstract" target="_blank">forms channels</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Human <a style="color: rgb(77, 167, 212);" href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5948a1.htm" target="_blank">paragonimiasis</a> (MMWR)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.foodsafetynews.com/2010/12/raw-crayfish-cause-rare-parasitic-disease/#.VQQ0_oHF990" target="_blank">Don't eat raw crawfish</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://microbeworld.org/images/stories/twip/IMG_2902.JPG" target="_blank">Daniel and Dickson in studio</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://crawfishtx.com/" target="_blank"><span style="line-height: 1.4em; background-color: initial;">Image credit</span></a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 4.4375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><span style="line-height: 1.4em; background-color: initial;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1863" target="_blank">Letters read</a> </span>on TWiP 85</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 84: Bigfoot
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Delivery of a <a style="color: rgb(77, 167, 212);" href="http://www.microbialcellfactories.com/content/13/1/156/abstract" target="_blank">functional nanobody</a> to tsetse flies (Microb Cell Fact)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Single-domain_antibody" target="_blank">Nanobodies</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">V.B. <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Wigglesworth" target="_blank">Wigglesworth</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.virology.ws/2009/01/27/john-updike-1932-2009/" target="_blank">VB Nimble, VB Quick</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.sonopath.com/articles/modified-knott-s-technique-and-direct-blood-smear" target="_blank">Knott test</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Mazzotti_Reaction" target="_blank">Mazzotti reaction</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://commons.wikimedia.org/wiki/File:Heavy_chain_and_common_antibody.svg" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.375px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><span style="line-height: 1.4em; background-color: initial;"><a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/parasitism-letters/1855-twip-84-letters" target="_blank">Letters read</a> </span>on TWiP 84</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p> </p>
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TWiP 83: Hidden costs of infection
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: #4da7d4;" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;">Effect of <a style="color: #4da7d4;" href="http://www.ncbi.nlm.nih.gov/pubmed/25613889" target="_blank">chronic malaria infection</a> on wild warblers (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;"><a style="color: #4da7d4;" href="http://commons.wikimedia.org/wiki/File:Drosselrohrs%C3%A4nger_Great_reed_warbler.jpg" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 3.625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;"><span style="line-height: 1.4em; background-color: initial;"><a href="http://www.microbeworld.org/component/content/article?id=1853" target="_blank">Letters read</a> </span>on TWiP 83</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: #4da7d4;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: #4da7d4;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: #4da7d4;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 82: A NOD to helminths
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.890625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.cdc.gov/parasites/babesiosis/" target="_blank">Babesiosis</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.890625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Babesiosis <a style="color: rgb(77, 167, 212);" href="http://www.nejm.org/doi/full/10.1056/NEJMicm070903" target="_blank">blood smear</a> with Maltese cross (NEJM)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.890625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Helminth proteins <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/24466007" target="_blank">prevent diabetes</a> in mice (PLoS One)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.890625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1843" target="_blank"><span style="line-height: 1.4em; background-color: initial;">Letters read</span></a><span style="line-height: 1.4em;"> on TWiP 82</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 81: Living in a wormy world
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Consequences of living in a <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/20849271" target="_blank">wormy world</a> (Am Nat)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25574023">Opposite effects</a> of antihelminthic treatment on microbial infection (Science)</li> <li style="height: 5.046875px;">Send your case study solutions to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Daniel's <a style="color: rgb(77, 167, 212);" href="images/stories/twip/IMG_2642.jpg" target="_blank">cufflinks</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Daniel's TB <a style="color: rgb(77, 167, 212);" href="images/stories/twip/IMG_2648.jpg" target="_blank">bowtie</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://commons.wikimedia.org/wiki/File:Serengeti_Bueffel1.jpg" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.046875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1836" target="_blank">Letters read</a><span style="line-height: 1.4em;"> on TWiP 81</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 80: Daniel in the parasites' den
<p style="margin: 0.2em 0px 1em; padding: 0px;"> Vincent and Dickson welcome new TWiP host Daniel to discuss the association of a new Mycoplasma with Trichomoniasis, and to introduce a new feature to the show, a case study.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a>, <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a>, and Daniel Griffin</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="height: 4.46875px;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206474/" target="_blank">Association of <em>Mycoplasma</em></a> with trichomoniasis (PLoS One)</li> <li style="height: 4.46875px;">Biggest <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Genome" target="_blank">DNA genomes</a> (Wikipedia)</li> <li style="height: 4.46875px;">Send your case study solutions to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv?subject=TWiP%20case%20study">twip@twiv.tv</a></li> <li style="height: 4.46875px;"><a style="color: rgb(77, 167, 212);" href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1828-tip-80-letters" target="_blank">Letters read</a><span style="line-height: 1.4em;"> on TWiP 80</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 79: Across the river and into the trees
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss the spread of <em>P. knowlesi</em> in Malaysia, and how <em>Leishmania</em> parasites protect the sandfly gut from bacterial infection.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Spread of <em>P. knowlesi</em> in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.nytimes.com/2014/11/11/health/a-rare-form-of-malaria-is-spreading-in-malaysia.html?ref=science&_r=1" target="_blank">Malaysia</a> (NY Times)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/25269959" target="_blank">Climate change in Europe</a> and vector transmitted disease (Infez Med)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.parasitesandvectors.com/content/7/1/329" target="_blank">Colonisation resistance</a> in the sandfly gut (Parasites & Vectors)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.wbur.org/npr/357428287/tom-magliozzi-popular-co-host-of-nprs-car-talk-dies-at-77" target="_blank">Car Talk</a> co-host dies</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Early Career Scientists <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://sites.lsa.umich.edu/ecss/" target="_blank">Symposium</a></li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;">Image credit: Anne Marie</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.515625px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="component/content/article?id=1805" target="_blank">Letters read</a><span style="line-height: 1.4em; background-color: initial;"> on TWiP 79</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 78: Eau de rodent
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss how malaria parasites induce odors in their rodent hosts that attract mosquitoes.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: #4da7d4;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.265625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;"><a style="color: #4da7d4;" href="http://www.promedmail.org/direct.php?id=2836861" target="_blank">Visceral Leishmaniasis</a>, South Sudan (ProMedMail)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.265625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;">Malaria-induced changes in <a style="color: #4da7d4;" href="http://www.pnas.org/content/111/30/11079.abstract" target="_blank">host odors</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 5.265625px; background: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif') 16px 0.35em no-repeat;"><a style="color: #4da7d4;" href="http://www.olaughingpress.org/2011/11/louie-named-rodent-of-year-by-rq.html" target="_blank">Image credit</a></li> <li style="height: 5.265625px;"><a style="color: #4da7d4; line-height: 1.4em; background-color: initial;" href="podcasts/this-week-in-parasitism/parasitism-letters/1791-twip-78-letters" target="_blank">Letters read</a><span style="line-height: 1.4em; background-color: initial;"> on TWiP 77</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: #4da7d4;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: #4da7d4;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: #4da7d4;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 77: Mixed messages
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss the exchange of messenger RNAs between a parasitic plant and its hosts.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.sciencemag.org/content/345/6198/808.full.html" target="_blank">Exchange of mRNAs</a> between parasite and plant (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Wheat_leaf_rust" target="_blank">White leaf rust</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Cuscuta" target="_blank"><em>Cuscuta</em></a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.pnas.org/content/98/14/7654.long" target="_blank">Fungal haustoria</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="line-height: 1.4em;" href="http://commons.wikimedia.org/wiki/File:Cuscuta_europaea_2005.06.12_15.07.24.jpg" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.796875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="podcasts/this-week-in-parasitism/parasitism-letters/1771-twip-77-letters" target="_blank">Letters read</a> on TWiP 77</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiP 76: Herpesvirus worms its way out
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss how infection of mice with helminths induces cytokines that reactivate a latent gamma-herpesvirus.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7.296875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Helminths <a style="color: rgb(77, 167, 212);" href="http://www.sciencemag.org/content/345/6196/573" target="_blank">reactivate herpesvirus</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7.296875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">How helminths <a style="color: rgb(77, 167, 212);" href="http://www.sciencemag.org/content/345/6196/517.full.html" target="_blank">go viral</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7.296875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/17507983" target="_blank">Herpesvirus latency</a> protects from bacterial infection (Nature)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Heligmosomoides_polygyrus" target="_blank">Image credit</a></li> <li style="height: 7.296875px;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1751" target="_blank"><span style="line-height: 1.4em;">Letters read</span></a><span style="line-height: 1.4em;"> on TWiP 76</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 75: Parasite wonders with Bobbi Pritt
<p style="margin: 0.2em 0px 1em; padding: 0px;">Bobbi Pritt joins Vincent and Dickson to talk about directing a clinical parasitology laboratory and her weekly case reports at Creepy Dreadful Wonderful Parasites.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Guest: <a style="color: rgb(77, 167, 212);" href="http://www.mayoclinic.org/biographies/pritt-bobbi-s-m-d/bio-20055034" target="_blank">Bobbi Pritt</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; line-height: 1.4em; height: 7.296875px; background: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif) 16px 0.35em no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://parasitewonders.blogspot.com/" target="_blank">Creepy Dreadful Wonderful Parasites</a></li> <li style="height: 7.296875px;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1729" target="_blank"><span style="line-height: 1.4em; background-color: initial;">Letters read</span></a><span style="line-height: 1.4em; background-color: initial;"> on TWiP 75</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 74: Nature has all the answers, what is your question?
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson review a novel malaria vaccine candidate comprising a parasite protein involved in egress from red blood cells.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212);" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul> <li>Egress protein a malaria <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/24855263" target="_blank">vaccine candidate</a> (Science)</li> <li><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Human_genome" target="_blank">Human proteins</a> (Wikipedia)</li> <li><em>Plasmodium</em> <a style="color: rgb(77, 167, 212);" href="http://plasmodb.org/plasmo/" target="_blank">genomics resource</a></li> <li>Image: <em>P. falciparum</em> ring forms and gametocytes in blood</li> <li><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1717" target="_blank"><span style="line-height: 1.4em; background-color: initial;">Letters read</span></a><span style="line-height: 1.4em; background-color: initial;"> on TWiP 74</span></li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212);" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 73: I'm nibbling my way back to you
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss how nibbling of human cells by <em>Entamoeba histolytica</em>, a process called amoebic trogocytosis, contributes to cell killing and tissue invasion.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Trogocytosis by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/24717428" target="_blank"><em>E. histolytica</em></a> (Nature)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Trogocytosis" target="_blank">Trogocytosis</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>Entamoeba histolytica</em> <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="podcasts/this-week-in-parasitism/archives/782-twip-17-entamoeba-histolytica" target="_blank">(TWiP 17)</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>Entamoeba histolytica</em> <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="images/stories/twip/e_histolytica_life_cycle.jpg" target="_blank">life cycle</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image: <em>E. histolytica</em> nibbling a green cell (<a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/24717428" target="_blank">credit</a>)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1706-twip-73-letters" target="_blank">Letters read</a> on TWiP 73</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 72: Wormholes
<p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss five ways that helminths manipulate host tissues to survive.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1004014" target="_blank">Wormholes</a> in host defense (PLoS Path)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Solitary_pulmonary_nodule" target="_blank">Lung coin</a> lesion (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Granuloma" target="_blank">Granuloma</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="images/stories/twip/IMG_1053.jpg" target="_blank">Jar that Dickson is holding</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/component/content/article?id=1693" target="_blank">Letters read</a> on TWiP 72</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 71: Happy trails to you
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson review the finding that urocanic acid in the skin is a chemoattractant for the parasitic nematode <em>Strongyloides stercoralis</em>.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Download <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://traffic.libsyn.com/twip/TWiP071.mp3" target="_blank">TWiP #71</a> (60 MB .mp3, 84 minutes).</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="podcasts/this-week-in-parasitism/archives/883-twip-23-strongyloides-sterocoralis-a-most-unusual-parasite" target="_blank"><em>Strongyloides stercoralis</em></a> (TWiP #71)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/17234810" target="_blank">Urocanic acid</a> is a <em>S. stercoralis</em> chemoattractant (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/17244701" target="_blank">Chemical trails</a> of parasites (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Urocanic_acid" target="_blank">Urocanic acid</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Candiru" target="_blank">Candiru</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://video.pbs.org/program/your-inner-fish/" target="_blank">Your Inner Fish</a> (PBS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="component/content/article?id=1674" target="_blank">Letters read</a> on TWiP 71</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 70: Invasion of the swamp eels
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss the finding of <span style="font-size: 9pt; font-family: Arial; font-style: italic;"><em>Gnathostoma</em> nematodes in Asian swamp eels from US live markets and wild populations.</span></p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Guinea worm <a style="color: #4da7d4; text-decoration: underline;" href="http://www.sciencemag.org/content/343/6168/236.summary" target="_blank">eradication at risk</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4; text-decoration: underline;" href="http://www.cdc.gov/parasites/gnathostoma/" target="_blank">Gnathostomiasis</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4; text-decoration: underline;" href="http://www.anstaskforce.gov/spoc/swamp_eel.php" target="_blank">Asian swamp eel</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4; text-decoration: underline;" href="http://wwwnc.cdc.gov/eid/article/20/4/13-1566_article.htm" target="_blank"><em>Gnathostoma</em></a> in live swamp eels (EID)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Interview with <a style="color: #4da7d4; text-decoration: underline;" href="https://www.youtube.com/watch?v=hyRUicSWdjM" target="_blank">Rebecca Cole</a> (YouTube)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1661-twip-70-letters" target="_blank">Letters read</a> on TWiP 70</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: #4da7d4; text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: #4da7d4; text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: #4da7d4; text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: #4da7d4; text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 69: Malaria rising
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson discuss an increase in the altitude of malaria distribution in warmer years in the highlands of Colombia and Ethiopia.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.sciencemag.org/content/343/6175/1154.abstract" target="_blank">Altitudinal changes</a> in malaria incidence (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/El_Niño" target="_blank">El Niño</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">NOAA <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.elnino.noaa.gov" target="_blank">El Niño page</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image credit: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.sciencemag.org/content/343/6175/1154.abstract" target="_blank">Science</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="component/content/article?id=1652" target="_blank">Letters read</a> on TWiP 69</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 68: Sex and the single trypanosome
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a>, and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://systemsbiology.columbia.edu/faculty/sagi-shapira" target="_blank">Sagi Shapira</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Dickson, and Sagi discuss evidence that the pathogen <em>Trypanosoma brucei</em> undergoes meiosis and sexual reproduction.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.sciencedirect.com/science/article/pii/S0960982213014991" target="_blank">Meiosis and haploid gametes</a> in <em>T. brucei</em> (Curr Biol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/File:Meiosis_diagram.jpg" target="_blank">Meiosis</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/component/content/article?id=1642" target="_blank">Letters read</a> on TWiP 68</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p>
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TWiP 67: They find each other delightful
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.verticalfarm.com">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Dickson explain the genetic and molecular basis of drug resistance in <em>Schistosoma mansonii</em>.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Basis of <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://www.ncbi.nlm.nih.gov/pubmed/24263136" target="_blank">resistance to oxamniquine</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://en.wikipedia.org/wiki/Oxamniquine" target="_blank">Oxamniquine</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212); text-decoration: underline;" href="component/content/article?id=1630" target="_blank">Letters read</a> on TWiP 67</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="mailto:twip@twiv.tv">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiP (free) in <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank">iTunes</a>, by the <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://twip.microbeworld.libsynpro.com/rss" target="_blank">RSS feed</a> or by <a style="color: rgb(77, 167, 212); text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a></p> <p> </p>
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TWiP 66: A nitrile warhead for Chagas disease
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.verticalfarm.com" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson discuss reversible inhibitors of cruzipain as new drugs for treating Chagas disease.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="height: 3px;"><a href="http://www.sciencemag.org/content/341/6145/514.abstract" target="_blank" data-mce-bootstrap="1" style="color: #4da7d4; text-decoration: underline;"></a>Reversible <a href="http://aac.asm.org/content/early/2013/12/03/AAC.01855-13" target="_blank" style="color: #4da7d4; text-decoration: underline;">cysteine protease inhibitors</a> for Chagas (AAC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">New <a href="http://www.sciencedaily.com/releases/2013/12/131226115336.htm" target="_blank" style="color: #4da7d4; text-decoration: underline;">drug candidates</a> for Chagas (ScienceDaily)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://youtu.be/Tx1M5d6Lwuc" target="_blank" style="color: #4da7d4; text-decoration: underline;">Pancake ice</a> (YouTube)</li> <li style="height: 3px;"><em></em>Letters read on TWiP 66</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;"> </p>
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TWiP 65: The real world wide web
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson consider the effects of climate change on parasitic diseases.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.sciencemag.org/content/341/6145/514.abstract" target="_blank" style="color: #4da7d4; text-decoration: underline;">Climate change</a> and infectious diseases (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">The more parasites <a href="http://www.ncbi.nlm.nih.gov/pubmed/24288315" target="_blank" style="color: #4da7d4; text-decoration: underline;">the better</a>? (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Host and parasite control <a href="http://www.pnas.org/content/110/42/16916.abstract" target="_blank" style="color: #4da7d4; text-decoration: underline;">disease risk</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Parasites dominate <a href="http://www.pnas.org/content/103/30/11211.long#aff-3" target="_blank" style="color: #4da7d4; text-decoration: underline;">food web links</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://astore.amazon.com/virologyws-20/detail/0312427905" target="_blank" style="color: #4da7d4; text-decoration: underline;"><em>The World Without Us</em></a> by Alan Weisman</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image credit: <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020193" target="_blank" style="color: #4da7d4; text-decoration: underline;">PLoS One</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em></em><a href="podcasts/this-week-in-parasitism/parasitism-letters/1610-twip-65-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 65</li> </ul> <h3 style="color: #bc0101;">Dickson's Pick</h3> <p style="color: #bc0101;"><a href="http://www.youtube.com/watch?v=lo1cRLdqKq4" target="_blank" style="color: #4da7d4; text-decoration: underline;"><em>Neglected</em></a><span style="color: #000000;"> by Shelly Xie (YouTube)</span></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 64: Three new ways to prevent malaria
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson review three novel approaches to antimalarial chemotherapy.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Targeting <a href="http://www.ncbi.nlm.nih.gov/pubmed/24284631" target="_blank" style="color: #4da7d4; text-decoration: underline;">PI(4)K</a> to eliminate malaria (Nature)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Antimicrobial peptides to target <a href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003790;jsessionid=343F2893E45D958AB676CB63833DF317" target="_blank" style="color: #4da7d4; text-decoration: underline;">sporogonic stages</a> of malaria (PLoS Path)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Small molecule blocks malaria <a href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003757" target="_blank" style="color: #4da7d4; text-decoration: underline;">invasion of mosquito</a> (PLoS Path)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.plospathogens.org/article/fetchSingleRepresentation.action?uri=info:doi/10.1371/journal.ppat.1003757.s003" target="_blank" style="color: #4da7d4; text-decoration: underline;">Photo credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="component/content/article?id=1601" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 64</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 63: Plasmodium of the apes
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson discuss evidence that the malaria parasite originated in gorillas.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Great apes and <a href="http://www.sciencemag.org/content/340/6130/284.accessible-long" target="_blank" style="color: #4da7d4; text-decoration: underline;">zoonoses</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Source of <a href="http://www.ncbi.nlm.nih.gov/pubmed/21903922" target="_blank" style="color: #4da7d4; text-decoration: underline;">human malaria</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Origin of human malaria parasite in <a href="http://www.ncbi.nlm.nih.gov/pubmed/20864995" target="_blank" style="color: #4da7d4; text-decoration: underline;">gorillas</a> (Nature)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Ape <em>Plasmodium</em> in Cameroon <a href="http://www.ncbi.nlm.nih.gov/pubmed/23569255" target="_blank" style="color: #4da7d4; text-decoration: underline;">not infecting humans</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/22691606" target="_blank" style="color: #4da7d4; text-decoration: underline;">No <em>Plasmodium</em></a> in greater spot-nosed monkey (Int J Parasit)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="podcasts/this-week-in-parasitism/archives/691-twip-13-toxoplasmosis" target="_blank" style="color: #4da7d4; text-decoration: underline;">TWiP 13: Toxoplasmosis</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/File:Cornelius_%26_Dr._Zaius_@_EMP-SFM.jpg" target="_blank" style="color: #4da7d4; text-decoration: underline;">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em></em><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1509-twip-63-letters" target="_blank">Letters read</a> on TWiP 62</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;"> </p>
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TWiP 62: More bats out of hell
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson discuss the high diversity of malaria parasites in West African bats, and a vaccine against hookworm.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="height: 1px;"><span style="line-height: 1.4em; color: #000000;">High diversity of West African <a href="http://www.pnas.org/content/early/2013/10/02/1311016110" target="_blank" style="color: #4da7d4; text-decoration: underline;">bat malaria parasites</a> (PNAS)</span></li> <li style="height: 1px;">Human <a href="http://www.ncbi.nlm.nih.gov/pubmed/23598487" target="_blank" style="color: #4da7d4; text-decoration: underline;">hookworm vaccine</a> (Vaccine)</li> <li style="height: 1px;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=j+allen+gongylonema" target="_blank" style="color: #4da7d4; text-decoration: underline;"><em>Gongylonema</em></a> infection in human (Am J Trop Med Hyg) </li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 1px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em></em><a href="component/content/article?id=1504" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 62</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;"> </p>
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TWiP 61: Some creep crept into the crypt and crapped
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Vincent and Dickson review examples of paleoparasitology, the detection of parasites in archaeological material.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=19789646" target="_blank" style="color: #4da7d4; text-decoration: underline;"><em>T. rex </em>had<em> Trichomonas</em></a> (PLoS One)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">King Richard III <a href="http://www.cnn.com/2013/09/04/world/europe/uk-king-richard-worms/index.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">had worms</a> (CNN)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Discovery of <a href="http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000900019" target="_blank" style="color: #4da7d4; text-decoration: underline;">toilets in Japan</a> (Mem Inst Os Cruz)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="https://tspace.library.utoronto.ca/html/1807/24191/oc03015.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">Paleoparasitology</a> in the Old World (Mem Inst Os Cruz)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.sciencedirect.com/science/article/pii/S0305440311003037" target="_blank" style="color: #4da7d4; text-decoration: underline;">Soils from Seoul</a> (J Arachael Sci)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://alexandriaarchive.org/bonecommons/archive/files/s1-6_27-08_araujo_cd762ebf14.pdf" target="_blank" style="color: #4da7d4; text-decoration: underline;">Ancient parasite infections</a> in Old World (pdf)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Ascaris in <a href="http://www.scielo.br/scielo.php?pid=S0074-02762008000100017&script=sci_arttext" target="_blank" style="color: #4da7d4; text-decoration: underline;">coprolites</a> (Mem Inst Os Cruz)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/12687769" target="_blank" style="color: #4da7d4; text-decoration: underline;">Human intestinal parasites</a> in the past (Mem Inst Os Cruz)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em></em><a href="http://www.microbeworld.org/component/content/article?id=1491" target="_blank">Letters read</a> on TWiP 61</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://twip.microbeworld.libsynpro.com/rss" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://eepurl.com/Gcw59" target="_blank" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 60: Urine a game of cat and mouse
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson discuss how infection with <em>Toxoplasma gondii</em> causes mice to lose their aversion to cat urine, even after the parasites have been cleared.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="height: 1px;"><em>T. gondii</em> in mice causes <a href="http://www.ncbi.nlm.nih.gov/pubmed/24058668" target="_blank" style="color: #4da7d4; text-decoration: underline;">loss of aversion</a> to cat urine (PLoS One)</li> <li style="height: 1px;">Cyclosporiasis <a href="http://www.cdc.gov/parasites/cyclosporiasis/outbreaks/investigation-2013.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">update</a> (CDC)</li> <li style="height: 1px;"><a href="podcasts/this-week-in-parasitism/parasitism-letters/1466-twip-59-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 60</li> </ul> <h3 style="color: #bc0101;">Listener Pick</h3> <p style="color: #bc0101;"><span style="color: #000000;"><strong>Blaine</strong> - <a href="http://www.fray.com/drugs/worm/" target="_blank" style="color: #4da7d4; text-decoration: underline;">The Worm Within</a></span></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 59: Apicomplexity
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson update the multistate outbreak of cyclosporiasis, discuss the avian malaria parasite <em>P. lophurae</em>, and review protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis <a href="http://www.cdc.gov/parasites/cyclosporiasis/outbreaks/investigation-2013.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">outbreak</a> in US (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001642;jsessionid=EE20D58E859B5B9ED2106660119BD34D" target="_blank" style="color: #4da7d4; text-decoration: underline;">Extraordinary history</a> of REV (PLoS Biology)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2011.06431.x/abstract;jsessionid=36CFFFA1B1BB62482458B60F1DA9577B.d04t04?deniedAccessCustomisedMessage=&userIsAuthenticated=false" target="_blank" style="color: #4da7d4; text-decoration: underline;">Avian malaria</a> (Ann NY Acad Sci)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em><a href="http://www.jstor.org/discover/10.2307/3273363?uid=3739808&uid=2129&uid=2&uid=70&uid=4&uid=3739256&sid=21102620702577" target="_blank" style="color: #4da7d4; text-decoration: underline;">P. lophurae</a></em> (J Parasitol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.twiv.tv/2013/09/01/twiv-248-twip-infects-twiv/" target="_blank" style="color: #4da7d4; text-decoration: underline;">TWiP infects TWiV</a> (TWiV 248)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Intravenous <a href="http://www.sciencemag.org/content/early/2013/08/07/science.1241800" target="_blank" style="color: #4da7d4; text-decoration: underline;">malaria vaccine</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.sciencemag.org/content/341/6146/605.summary" target="_blank" style="color: #4da7d4; text-decoration: underline;">Unconventional</a> malaria vaccine (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image of apicomplexan structure: <a href="http://en.wikipedia.org/wiki/Apicomplexa" target="_blank" style="color: #4da7d4; text-decoration: underline;">Wikipedia</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1466-twip-59-letters" target="_blank">Letters read</a> on TWiP 59</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 58: People, parasites, and plowshares
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Guest: Cali Despommier</p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson update the multistate outbreak of cyclosporiasis, and Dickson reads a chapter from his new book.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="images/stories/twip/IMG_4416.JPG" target="_blank" style="color: #4da7d4; text-decoration: underline;">Dickson and Cali</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis <a href="http://www.promedmail.org/direct.php?id=20130807.1869333" target="_blank" style="color: #4da7d4; text-decoration: underline;">keeps spreading</a> (ProMedMail)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis is <a href="http://gawker.com/stomach-virus-tied-to-olive-garden-and-red-lobster-law-1020790489" target="_blank" style="color: #4da7d4; text-decoration: underline;">not a virus!</a> (Gawker)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis is <a href="http://news.yahoo.com/stomach-virus-linked-produce-sickens-285-people-11-181419615.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">not a virus!</a> (Yahoo)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.theglobaldispatch.com" target="_blank" style="color: #4da7d4; text-decoration: underline;">The Global Dispatch</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://astore.amazon.com/virologyws-20/detail/0231161948" target="_blank" style="color: #4da7d4; text-decoration: underline;">People, Parasites, and Plowshares</a> by Dickson Despommier</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 2px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="podcasts/this-week-in-parasitism/parasitism-letters/1449-twip-58-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 58</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 57: An outbreak of cyclosporiasis
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson review a multistate outbreak of cyclosporiasis caused by the single-celled coccidian parasite <em>Cyclospora</em> <em>cayetanensis</em>.</p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">The day after recording this episode, <a href="http://www.promedmail.org/direct.php?id=20130717.1830589" target="_blank" style="color: #4da7d4; text-decoration: underline;">ProMedMail reported</a> that the outbreak of cyclosporiasis had spread to Texas.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.cdc.gov/parasites/cyclosporiasis/" target="_blank" style="color: #4da7d4; text-decoration: underline;">Cyclosporiasis</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>Cyclospora</em> <a href="http://www.cdc.gov/parasites/cyclosporiasis/biology.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">life cycle</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/Cyclosporiasis" target="_blank" style="color: #4da7d4; text-decoration: underline;">Cyclosporiasis</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis outbreak, US (<a href="http://www.promedmail.org/direct.php?id=20130708.1813279" target="_blank" style="color: #4da7d4; text-decoration: underline;">one</a>, <a href="http://www.promedmail.org/direct.php?id=20130713.1823517" target="_blank" style="color: #4da7d4; text-decoration: underline;">two</a>, <a href="http://www.promedmail.org/direct.php?id=20130715.1825812" target="_blank" style="color: #4da7d4; text-decoration: underline;">three</a>) (ProMedMail)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Cyclosporiasis outbreak moves to <a href="http://www.promedmail.org/direct.php?id=20130717.1830589" target="_blank" style="color: #4da7d4; text-decoration: underline;">Texas</a> (ProMedMail)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6053a1.htm?s_cid=mm6053a1_e" target="_blank" style="color: #4da7d4; text-decoration: underline;">Notifiable diseases</a>, US, 2011 (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.virology.ws/2013/07/08/federal-funding-for-science-research/" target="_blank" style="color: #4da7d4; text-decoration: underline;">Federal funding</a> for science research (virology blog)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://youtu.be/lP1i403VPiM" target="_blank" style="color: #4da7d4; text-decoration: underline;">Oculus</a> of Singapore (YouTube)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Dickson <a href="images/stories/twip/IMG_4197.JPG" target="_blank" style="color: #4da7d4; text-decoration: underline;">recording</a> TWiP 57 (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Dickson's <a href="images/stories/twip/IMG_4198.JPG" target="_blank" style="color: #4da7d4; text-decoration: underline;">stuff</a> (jpg)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://astore.amazon.com/virologyws-20/detail/0231161948" target="_blank" style="color: #4da7d4; text-decoration: underline;">People, Parasites, and Plowshares</a> by Dickson Despommier</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 57</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 56: Whirling disease
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson discuss <em>Myxobolus cerebralis</em>, the parasite that causes whirling disease of salmonids.</p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;"><span style="color: #bc0101; font-size: 1.2em;">Links for this episode:</span></p> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/Myxobolus_cerebralis" target="_blank" style="color: #4da7d4; text-decoration: underline;">Myxobolus cerebralis</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Fish <a href="http://en.wikipedia.org/wiki/Fish_migration" target="_blank" style="color: #4da7d4; text-decoration: underline;">migration</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Trout with <a href="http://youtu.be/S5a0GrrymNo" target="_blank" style="color: #4da7d4; text-decoration: underline;">whirling disease</a> (YouTube)<br /><br /></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 55</li> </ul> <h3 style="color: #bc0101;">Listener Pick</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Amanda - <a href="http://astore.amazon.com/virologyws-20/detail/B00CAG5LJ2" target="_blank" style="color: #4da7d4; text-decoration: underline;">Pandemic: On the Brink</a></p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 55: A ladybird's weapon
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson reveal how invasive harlequin ladybirds use biological weapons against their competitors.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Invasive Harlequin Ladybirds' <a href="http://www.ncbi.nlm.nih.gov/pubmed/23687046" target="_blank" style="color: #4da7d4; text-decoration: underline;">biological weapon</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Immunity an <a href="http://www.sciencemag.org/content/340/6134/816.summary" target="_blank" style="color: #4da7d4; text-decoration: underline;">invasive success</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Invading ladybugs carry <a href="http://cen.acs.org/articles/91/i21/Invading-Ladybugs-Carry-Bioweapons.html" target="_blank" style="color: #4da7d4; text-decoration: underline;">bioweapons</a> (C&EN)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/Ladybird_Ladybird" target="_blank" style="color: #4da7d4; text-decoration: underline;">Ladybird Ladybird</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/G._Evelyn_Hutchinson" target="_blank" style="color: #4da7d4; text-decoration: underline;">G. Evelyn Hutchinson</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 55</li> </ul> <h3 style="color: #bc0101;">Dickson's Pick</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;"><a href="http://astore.amazon.com/virologyws-20/detail/0520223233" target="_blank" style="color: #4da7d4; text-decoration: underline;">An Inordinate Fondess for Beetles</a> by Arthur V. Evans, Charles L. Bellamy</p> <h3 style="color: #bc0101;">Listener Pick</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Jessie - <a href="http://astore.amazon.com/virologyws-20/detail/B00A2HD40E" target="_blank" style="color: #4da7d4; text-decoration: underline;">Pandemic</a>, the board game</p> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p>
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TWiP 54: Unde venis?
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson consider a case history of a young man with <em>Blastocystis hominis</em> - is it causing his disease?</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/Blastocystis" target="_blank" style="color: #4da7d4; text-decoration: underline;">Blastocystis</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>Blastocystis</em> <a href="http://www.ncbi.nlm.nih.gov/pubmed/22738855" target="_blank" style="color: #4da7d4; text-decoration: underline;">review</a> (Trends Parasitol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/podcasts/this-week-in-parasitism/parasitism-letters/1401-twip-54-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 54</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p> <h3 style="color: #bc0101;">Subscribe (free)</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Subscribe to TWiP (free) in <a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="color: #4da7d4; text-decoration: underline;">iTunes</a>, by the <a href="http://feeds.feedburner.com/parasitism" target="_blank" style="color: #4da7d4; text-decoration: underline;">RSS feed</a> or by <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="color: #4da7d4; text-decoration: underline;">email</a></p>
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TWiP 53: Anti-saliva immunity
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Immunity to a salivary protein <a href="http://www.pnas.org/content/105/22/7845.long" target="_blank" style="color: #4da7d4; text-decoration: underline;">protects against leishmaniasis</a> (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image of blood-fed <em>Lutzomyia longipalpis</em> (right) <a href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fimage.ppat.v05.i08" target="_blank" style="color: #4da7d4; text-decoration: underline;">credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Short history of <a href="http://scienceleftuntitled.wordpress.com/2012/03/29/a-short-history-of-leishmania-vaccines/" target="_blank" style="color: #4da7d4; text-decoration: underline;">Leishmania vaccines</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>Leishmania</em> on <a href="podcasts/this-week-in-parasitism/archives/712-twip-14-leishmania" target="_blank" style="color: #4da7d4; text-decoration: underline;">TWiP #14</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="podcasts/this-week-in-parasitism/parasitism-letters/1387-twip-53-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 53</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p>
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TWiP 52: Not your ordinary unsegmented roundworm
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson review the life cycle and pathogenesis of the giant kidney worm, <em>Dioctophyme renale</em>.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.dpd.cdc.gov/dpdx/HTML/Dioctophymiasis.htm" target="_blank" style="color: #4da7d4; text-decoration: underline;">Dioctophymiasis</a> (CDC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em><a href="http://en.wikipedia.org/wiki/Dioctophyme_renale" target="_blank" style="color: #4da7d4; text-decoration: underline;">Dioctophyme renale</a></em> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Fatal bilateral <a href="http://www.ncbi.nlm.nih.gov/pubmed/21158627" target="_blank" style="color: #4da7d4; text-decoration: underline;">dioctophymiasis</a> (J Parasitol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em><a href="http://www.amazon.com/Clinical-Parasitology-Paul-Chester-Beaver/dp/0812108760/ref=sr_1_1?ie=UTF8&qid=1363462832&sr=8-1&keywords=paul+beaver+clinical+parasitology" target="_blank" style="color: #4da7d4; text-decoration: underline;">Clinical Parasitology</a></em> by Paul C. Beaver</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><em>D. renale</em> <a href="http://www.sciencedirect.com/science/article/pii/S0304401709006621" target="_blank" style="color: #4da7d4; text-decoration: underline;">in a dog</a> (Vet. Parasitol.)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.youtube.com/watch?v=5ob6S_EqR1c" target="_blank" style="color: #4da7d4; text-decoration: underline;">Surgical removal</a> of <em>D. renale</em> (YouTube)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 52</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p>
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TWiP 51: Modifying mosquitoes with Anthony A. James
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Guest: <a href="http://www.faculty.uci.edu/scripts/UCIFacultyProfiles/fac_detail.CFM?ID=2154" target="_blank" style="color: #4da7d4; text-decoration: underline;">Anthony A. James</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Special guest Anthony A. James joins Vincent and Dickson to discuss how mosquitoes can be genetically modified to control infectious diseases.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/23350003" target="_blank" style="color: #4da7d4; text-decoration: underline;">Field cage studies</a> of modified mosquitoes (PLoS NTD)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20176967" target="_blank" style="color: #4da7d4; text-decoration: underline;">Flightless</a> mosquitoes (PNAS)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">When <a href="http://www.nytimes.com/2013/02/24/magazine/when-mutant-mosquitoes-attack.html?pagewanted=all&_r=1&" target="_blank" style="color: #4da7d4; text-decoration: underline;">mutant mosquitoes</a> attack (NY Times)</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv" target="_parent" style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p>
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TWiP 50: Antagonism in the mosquito midgut
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito.</p> <h3 style="color: #bc0101;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding-top: 0.2em; padding-bottom: 0.2em; height: 6.03125px;">Malaria parasites <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=lasonder+simon" target="_blank" style="color: #4da7d4; text-decoration: underline;">co-opt factor H</a> (Cell Host Microbe)</li> <li style="padding-top: 0.2em; padding-bottom: 0.2em; height: 6.03125px;"><a href="http://en.wikipedia.org/wiki/Complement_system" target="_blank" style="color: #4da7d4; text-decoration: underline;">Complement</a> system (Wikipedia)</li> <li style="padding-top: 0.2em; padding-bottom: 0.2em; height: 6.03125px;"><a href="podcasts/this-week-in-parasitism/parasitism-letters" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiP 50</li> </ul> <h3 style="color: #bc0101;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to <a href="mailto:twip@twiv.tv." style="color: #4da7d4; text-decoration: underline;">twip@twiv.tv</a></p>
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TWiP 49: Making sense of toxo and heme
<p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.trichinella.org" style="color: #4da7d4; text-decoration: underline;">Dickson Despommier</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Vincent and Dickson discuss innate immune sensing of <em>Toxoplasma gondii</em> in mice, and heme metabolism in protozoan parasites.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55; text-align: left;">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none; font-size: 11px; text-align: left;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.cell.com/cell-host-microbe/abstract/S1931-3128(12)00429-5" target="_blank" style="color: #4da7d4; text-decoration: underline;">Sensing</a> <em>Toxoplasma</em> in mice (Cell Host Microbe)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003088" target="_blank" style="color: #4da7d4; text-decoration: underline;">Make it, take it, or leave it</a> (PLoS Path)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://en.wikipedia.org/wiki/Heme" target="_blank" style="color: #4da7d4; text-decoration: underline;">Heme</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Letters read on TWiP 49</li> </ul> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55; text-align: left;">Contact</h3> <p style="margin: 0.2em 0px 1em; padding: 0px; font-size: 11px; text-align: left;">Send your questions and comments (email or mp3 file) to twip@twiv.tv</p>
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TWiP 48: A parasitic cloaking device
<p style="font-family: Times; font-size: medium;">Hosts: <a target="_blank" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a>, <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a>, and Josef Sabo</p> <p style="font-family: Times; font-size: medium;">Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins.</p> <h3 style="font-family: Times;">Links for this episode:</h3> <ul style="font-family: Times; font-size: medium;"> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">S. japonicum</span> tetraspanin-2 as a <a target="_blank" href="http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001166" mce_href="http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001166">vaccine target</a> (PLoS NTP)</li> <li>Protection with <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">S. mansoni</span> <a target="_blank" href="http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001564" mce_href="http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001564">tetraspanin-2</a> (PLoS NTP)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">S. mansoni</span> tetraspanins <a target="_blank" href="http://www.nature.com/nm/journal/v12/n7/full/nm1430.html" mce_href="http://www.nature.com/nm/journal/v12/n7/full/nm1430.html">confer protection</a> (Nat Med)</li> <li><a target="_blank" href="http://en.wikipedia.org/wiki/Tetraspanin" mce_href="http://en.wikipedia.org/wiki/Tetraspanin">Tetraspanins</a></li> <li><a href="index.php?option=com_content&view=article&id=1310" mce_href="index.php?option=com_content&view=article&id=1310" target="_blank">Letters read</a> on TWiP 48</li> </ul> <h3 style="font-family: Times;">Contact</h3> <p style="font-family: Times; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3 style="font-family: Times;">Subscribe (free)</h3> <p><span style="font-family: Times; font-size: medium;">Subscribe to TWiP (free) in </span><a target="_blank" href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" mce_href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" style="font-family: Times; font-size: medium;">iTunes</a><span style="font-family: Times; font-size: medium;">, by the </span><a target="_blank" href="http://feeds.feedburner.com/parasitism" mce_href="http://feeds.feedburner.com/parasitism" style="font-family: Times; font-size: medium;">RSS feed</a><span style="font-family: Times; font-size: medium;"> or by </span><a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" mce_href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="font-family: Times; font-size: medium;">email</a></p>
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TWiP 47: For whom the trich tolls
<p style="font-family: Times; font-size: medium;">Hosts: <a target="_blank" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Times; font-size: medium;">Vincent and Dickson review evidence that a virus of the protozoan parasite <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Trichomonas vaginalis</span> may exacerbate disease.</p> <h3 style="font-family: Times;">Links for this episode:</h3> <ul style="font-family: Times; font-size: medium;"> <li>Endobiont viruses <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048418" mce_href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048418" target="_blank">sensed by the human host</a> (PLoS One)</li> <li><a href="index.php?option=com_content&view=article&id=1310:twip-46-letters&catid=102:twip-letters&Itemid=267" mce_href="index.php?option=com_content&view=article&id=1310:twip-46-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters read</a> on TWiP 47</li> </ul> <h3 style="font-family: Times;">Contact</h3> <p style="font-family: Times; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv</p>
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TWiP 46: Malaria gets the (zinc) finger
<p style="font-family: Times; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Times; font-size: medium;">Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Plasmodium falciparum</span>using zinc finger nucleases.</p> <p style="font-family: Times; font-size: medium;">Right-click to download <a href="http://traffic.libsyn.com/twip/TWiP046.mp3" mce_href="http://traffic.libsyn.com/twip/TWiP046.mp3" target="_blank">TWiP #46</a> (46 MB .mp3, 64 minutes).</p> <h3 style="font-family: Times;">Links for this episode:</h3> <ul style="font-family: Times; font-size: medium;"> <li><a target="_blank" href="http://www.microbiology.columbia.edu/fidock/judith_straimer.html" mce_href="http://www.microbiology.columbia.edu/fidock/judith_straimer.html">Judith Straimer</a> and <a target="_blank" href="http://www.microbiology.columbia.edu/fidock/marcus_lee.html" mce_href="http://www.microbiology.columbia.edu/fidock/marcus_lee.html">Marcus Lee</a></li> <li><a target="_blank" href="http://www.nature.com/nmeth/journal/v9/n10/full/nmeth.2143.html" mce_href="http://www.nature.com/nmeth/journal/v9/n10/full/nmeth.2143.html">Genome editing</a> in <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">P. falciparum</span> with zinc finger nucleases (Nature Methods)</li> <li><a target="_blank" href="http://www.sigmaaldrich.com/life-science/zinc-finger-nuclease-technology.html" mce_href="http://www.sigmaaldrich.com/life-science/zinc-finger-nuclease-technology.html">Zinc finger nucleases</a> (Sigma-Aldrich)</li> <li><a target="_blank" href="http://www.nature.com/nmeth/journal/v9/n1/full/nmeth.1807.html" mce_href="http://www.nature.com/nmeth/journal/v9/n1/full/nmeth.1807.html">Gene-editing nucleases</a> (Nature Methods)</li> <li>Illustration by <a href="http://www.microbiology.columbia.edu/fidock/" mce_href="http://www.microbiology.columbia.edu/fidock/" target="_blank">Andrew Lee</a></li> </ul> <h3 style="font-family: Times;">Contact</h3> <p style="font-family: Times; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p>
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TWiP 45: Free range Toxoplasma with John Boothroyd
<p></p> <p style="font-family: Times; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Times; font-size: medium;">Vincent and Dickson discuss <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Toxoplasma</span> biology with Stanford University Professor <a target="_blank" href="http://boothroydlab.stanford.edu" mce_href="http://boothroydlab.stanford.edu">John Boothroyd</a>.</p> <h3>Links for this episode:</h3> <ul style="font-family: Times; font-size: medium;"> <li>T. gondii and <a href="http://pennstatefoodsafety.blogspot.com/2012/06/increased-risk-of-t-gondii-in-free.html" mce_href="http://pennstatefoodsafety.blogspot.com/2012/06/increased-risk-of-t-gondii-in-free.html" target="_blank">free range animals</a></li> <li>Kiss and spit: <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" mce_fixed="1" style="font-style: italic;">Toxoplasma</span> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/18059289?dopt=Abstract&otool=stanford" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/18059289?dopt=Abstract&otool=stanford">rhoptries</a> (Nat Rev Micro)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Toxoplasma</span> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/16837236?dopt=Abstract&otool=stanford" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/16837236?dopt=Abstract&otool=stanford">cell invasion</a> (Curr Opin Micro)</li> <li><a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/20109161?dopt=Abstract&otool=stanford" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/20109161?dopt=Abstract&otool=stanford">Loading of IRG</a> onto parasitophorous vacuole (Cell Micro)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Toxoplasma gondii </span><a target="_blank" href="index.php?option=com_content&view=article&id=674:twip-12-toxoplasma-gondii&catid=99:this-week-in-parasitism&Itemid=259" mce_href="index.php?option=com_content&view=article&id=674:twip-12-toxoplasma-gondii&catid=99:this-week-in-parasitism&Itemid=259">on TWiP #12</a></li> </ul> <h3>Contact</h3> <p style="font-family: Times; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3>Subscribe (free)</h3> <p><span style="font-family: Times; font-size: medium;">Subscribe to TWiP (free) in </span><a href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" mce_href="http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=340512495" target="_blank" style="font-family: Times; font-size: medium;">iTunes</a><span style="font-family: Times; font-size: medium;">, at the </span><a href="http://social.zune.net/podcast/This-Week-in-Parasitism/363d85a8-2118-40cd-8dba-161da9e9f9ec" mce_href="http://social.zune.net/podcast/This-Week-in-Parasitism/363d85a8-2118-40cd-8dba-161da9e9f9ec" target="_blank" style="font-family: Times; font-size: medium;">Zune Marketplace</a><span style="font-family: Times; font-size: medium;">, by the </span><a href="http://feeds.feedburner.com/parasitism" mce_href="http://feeds.feedburner.com/parasitism" target="_blank" style="font-family: Times; font-size: medium;">RSS feed</a><span style="font-family: Times; font-size: medium;"> or by</span><a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" mce_href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US" style="font-family: Times; font-size: medium;"> email</a></p> <p></p>
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TWiP 44: Parasites provide a cricket subsidy for trout
<p style="font-family: Verdana; font-size: medium;"><span style="font-size: x-small;">Hosts: <a target="_blank" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a href="http://www.trichinella.org/" mce_href="http://www.trichinella.org">Dickson Despommier</a></span></p> <p style="font-family: Verdana; font-size: medium;"><span style="font-size: x-small;">Vincent and Dickson explain how a nematode manipulates cricket behavior and alters the food web of a stream.</span></p> <h3 style="font-family: Verdana;"><span style="font-size: x-small;">Links for this episode:</span></h3> <ul style="font-family: Verdana; font-size: medium;"> <li><span style="font-size: x-small;">Nematomorph parasites <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nematomorph%20parasites%20indirectly%20alter%20the%20food%20web" mce_href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nematomorph%20parasites%20indirectly%20alter%20the%20food%20web">alter food web of streams</a> (Ecol Lett)</span></li> <li><span style="font-size: x-small;"><a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/9614326" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/9614326">Manipulation of cockle behavior</a> by a trematode (Parasitology)</span></li> <li><span style="font-size: x-small;">Cockles infected by one parasite are <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed/9794655" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/9794655">more susceptible to a second</a> (J Parasitol)</span></li> <li><span style="font-size: x-small;"><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=1270:twip-44-letters&catid=102:twip-letters&Itemid=267" mce_href="http://microbeworld.org/index.php?option=com_content&view=article&id=1260" target="_blank">Letters read</a> on TWiP 44</span></li> </ul> <h3 style="font-family: Verdana;"><span style="font-size: x-small;">Contact</span></h3> <p style="font-family: Verdana; font-size: medium;"><span style="font-size: x-small;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</span></p>
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TWiP 43: Two remarkable host-parasite conflicts
<p style="font-family: Verdana; font-size: medium;">Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes.</p> <h3 style="font-family: Verdana;">Links for this episode:</h3> <ul style="font-family: Verdana; font-size: medium;"> <li>microRNAs involved in <a href="http://www.cell.com/cell-host-microbe/abstract/S1931-3128(12)00234-X" mce_href="http://www.cell.com/cell-host-microbe/abstract/S1931-3128(12)00234-X" target="_blank">sickle cell resistance</a> to <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Plasmodium</span> (Cell Host Microbe)</li> <li><a href="http://www.sciencemag.org/content/337/6093/463.abstract?sid=6c9340f4-a214-4976-9ef8-65af4c277f87" mce_href="http://www.sciencemag.org/content/337/6093/463.abstract?sid=6c9340f4-a214-4976-9ef8-65af4c277f87" target="_blank">Trypanosome adenylate cyclases</a> modulate innate immune response (Science)</li> <li><a href="http://microbeworld.org/index.php?option=com_content&view=article&id=1260" mce_href="http://microbeworld.org/index.php?option=com_content&view=article&id=1260" target="_blank">Letters read</a> on TWiP 43</li> </ul> <h3 style="font-family: Verdana;">Contact</h3> <p style="font-family: Verdana; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p>
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TWiP 42: The tick keeps on ticking
<p style="font-family: Verdana; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Verdana; font-size: medium;">Vincent and Dickson answer listener emails about <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Leishmania</span>, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more.</p> <h3 style="font-family: Verdana;">Links for this episode:</h3> <ul style="font-family: Verdana; font-size: medium;"> <li><a href="http://www.annualreviews.org/doi/full/10.1146/annurev-micro-090110-102913" mce_href="http://www.annualreviews.org/doi/full/10.1146/annurev-micro-090110-102913" target="_blank">Metabolic pathways</a> required by <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Leishmania</span> (Ann Rev Micro)</li> <li>Tapeworms in <a href="http://discovermagazine.com/2012/jun/03-hidden-epidemic-tapeworms-in-the-brain" mce_href="http://discovermagazine.com/2012/jun/03-hidden-epidemic-tapeworms-in-the-brain" target="_blank">people's brains</a> (Carl Zimmer)</li> <li><a href="http://www.poison-ivy.org/html/faq.htm" mce_href="http://www.poison-ivy.org/html/faq.htm" target="_blank">Poison Ivy</a></li> <li>Bovine tuberculosis <a href="http://www.nature.com/news/bovine-tb-disguised-by-liver-fluke-1.10685" mce_href="http://www.nature.com/news/bovine-tb-disguised-by-liver-fluke-1.10685" target="_blank">disguised by liver fluke</a> (Nature)</li> <li><a href="http://youtu.be/5ob6S_EqR1c" mce_href="http://youtu.be/5ob6S_EqR1c" target="_blank">Giant kidney worm</a> (YouTube)</li> <li><a href="http://biogames.ee.ucla.edu/" mce_href="http://biogames.ee.ucla.edu/" target="_blank">Crowd-sourced games</a> for telepathology</li> <li>Ivermectin for <a href="http://www.abc.net.au/radionational/programs/scienceshow/drug-shows-promise-as-treatment-for-alcohol-abuse/4006394" mce_href="http://www.abc.net.au/radionational/programs/scienceshow/drug-shows-promise-as-treatment-for-alcohol-abuse/4006394" target="_blank">alcohol abuse</a></li> <li>Ivermectin and <a href="http://www.sciencedirect.com/science/article/pii/S0028390812001128" mce_href="http://www.sciencedirect.com/science/article/pii/S0028390812001128" target="_blank">alcohol abuse in mice</a> (Neuropharm)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/15463486" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/15463486" target="_blank">Etymology of Loa</a></li> <li><a href="http://www.bbc.co.uk/news/world-asia-india-18640495" mce_href="http://www.bbc.co.uk/news/world-asia-india-18640495" target="_blank">Worm removed</a> from man's eye (BBC)</li> <li><a href="http://m.phys.org/news/2012-03-survive-subjected-electron-microscopy.html" mce_href="http://m.phys.org/news/2012-03-survive-subjected-electron-microscopy.html" target="_blank">Ticks keep on ticking</a> (<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032676" mce_href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032676" target="_blank">PLoS One article</a>)</li> <li><a target="_blank" href="http://microbeworld.org/index.php?option=com_content&view=article&id=1251" mce_href="http://microbeworld.org/index.php?option=com_content&view=article&id=1251">Letters read</a> on TWiP 42</li> </ul> <h3 style="font-family: Verdana;">Contact</h3> <p style="font-family: Verdana; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p>
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TWiP 41: Flying and crawling beasts
<p style="font-family: Verdana; font-size: medium;">Hosts: <a target="_blank" href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Verdana; font-size: medium;">Vincent and Dickson review medically important arthropods.</p> <h3 style="font-family: Verdana; font-size: medium;">Links for this episode:</h3> <ul style="font-family: Verdana; font-size: medium;"> <li><a href="http://www.nbb.cornell.edu/neurobio/eisner/eisner.html" mce_href="http://www.nbb.cornell.edu/neurobio/eisner/eisner.html" target="_blank">Thomas Eisner</a></li> <li><a href="http://microbeworld.org/images/stories/twip/391ill.jpg" mce_href="images/stories/twip/391ill.jpg" target="_blank">Incomplete metamorphosis</a> in insects (jpg)</li> <li><span id=""><a href="http://microbeworld.org/images/stories/twip/392ill.jpg" mce_href="images/stories/twip/392ill.jpg" target="_blank">Complete metamorphosis</a> in an insect with aquatic immature stages (jpg)</span></li> <li><span><span id=""><a href="http://microbeworld.org/images/stories/twip/393ill.jpg" mce_href="images/stories/twip/393ill.jpg" target="_blank">Complete metamorphosis</a> in an insect with terrestrial immature stages (jpg)</span></span></li> <li><a href="index.php?option=com_content&view=article&id=1224:twip-41-letters&catid=102:twip-letters&Itemid=267" mce_href="index.php?option=com_content&view=article&id=1224:twip-41-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters read</a> on TWiP 41</li> </ul> <h3 style="font-family: Verdana; font-size: medium;">Contact</h3> <p><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</span></p>
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TWiP 40: Doctor, there's a worm in my eye!
<p style="font-family: Verdana; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Verdana; font-size: medium;">Vincent and Dickson discuss loaiasis caused by the filarial nematode <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Loa loa</span>.</p> <p style="font-family: Verdana; font-size: medium;">Right-click to download <a href="http://traffic.libsyn.com/twip/TWiP040.mp3" mce_href="http://traffic.libsyn.com/twip/TWiP040.mp3" target="_blank">TWiP #40</a> (52 MB .mp3, 73 minutes).</p> <h3 style="font-family: Verdana; font-size: medium;">Links for this episode:</h3> <ul style="font-family: Verdana; font-size: medium;"> <li><a href="http://www.nejm.org/doi/full/10.1056/NEJMoa1103360" mce_href="http://www.nejm.org/doi/full/10.1056/NEJMoa1103360" target="_blank">Albendazole therapy</a> for US-bound refugees (NEJM)</li> <li><a target="_blank" href="http://microbeworld.org/images/stories/twip/loa_microfilariae.jpg" mce_href="images/stories/twip/loa_microfilariae.jpg">Microfilaria</a> of <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Loa loa</span> (png)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Loa loa</span> <a target="_blank" href="http://microbeworld.org/images/stories/twip/loa_lifecycle.png" mce_href="images/stories/twip/loa_lifecycle.png">life cycle</a> (png)</li> <li><a target="_blank" href="http://microbeworld.org/index.php?option=com_content&view=article&id=1199:twip-40-letters&catid=102:twip-letters&Itemid=267" mce_href="index.php?option=com_content&view=article&id=1199:twip-40-letters&catid=102:twip-letters&Itemid=267">Letters read</a> on TWiP 40</li> </ul> <h3 style="font-family: Verdana; font-size: medium;">Contact</h3> <p><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</span></p>
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TWiP 39: I encyst, said the amoeba
<p style="font-family: 'Lucida Grande'; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: 'Lucida Grande'; font-size: medium;">Vincent and Dickson review the biology and pathogenesis of the amoebae <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Naegleria fowlerii</span> and <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Acanthamoeba castellani</span>.</p> <h3 style="font-family: 'Lucida Grande'; font-size: medium;">Links for this episode:</h3> <ul style="font-family: 'Lucida Grande'; font-size: medium;"> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">N. fowlerii</span> <a target="_blank" href="http://www.cdc.gov/parasites/naegleria/biology.html" mce_href="http://www.cdc.gov/parasites/naegleria/biology.html">life cycle</a> (CDC)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">N. fowlerii at </span><a target="_blank" href="http://blogs.scientificamerican.com/artful-amoeba/2011/08/17/just-what-is-the-brain-eating-amoeba-naegleria-fowleri/" mce_href="http://blogs.scientificamerican.com/artful-amoeba/2011/08/17/just-what-is-the-brain-eating-amoeba-naegleria-fowleri/">Artful Amoeba</a></li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Naegleria</span> and <a target="_blank" href="http://www.health.state.mn.us/divs/idepc/diseases/naegleria/index.html" mce_href="http://www.health.state.mn.us/divs/idepc/diseases/naegleria/index.html">amoebic meningoencephalitis</a> (MDPH)</li> <li><a target="_blank" href="http://wwwnc.cdc.gov/eid/article/10/10/04-0273_article.htm" mce_href="http://wwwnc.cdc.gov/eid/article/10/10/04-0273_article.htm">First case</a> of <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Naegleria</span> PAM in Italy (Emerg Inf Dis)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">N. fowlerii</span> in <a target="_blank" href="http://wwwnc.cdc.gov/eid/article/14/9/07-1076_article.htm" mce_href="http://wwwnc.cdc.gov/eid/article/14/9/07-1076_article.htm">well water</a> (Emerg Inf Dis)</li> <li>Recent <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">N. fowlerii</span> case in <a target="_blank" href="http://cid.oxfordjournals.org/content/early/2012/01/09/cid.cir961.short?rss=1" mce_href="http://cid.oxfordjournals.org/content/early/2012/01/09/cid.cir961.short?rss=1">Minnesota</a> (Clin Inf Dis)</li> <li>Beat the <a target="_blank" href="http://www.smh.com.au/travel/traveller-tips/beat-the-holiday-bug-20120419-1x8f9.html" mce_href="http://www.smh.com.au/travel/traveller-tips/beat-the-holiday-bug-20120419-1x8f9.html">holiday bug</a> (Sydney Morning Herald)</li> <li>Is your <a target="_blank" href="http://www.dallasnews.com/health/headlines/20120423-dallas-doctors-weigh-in-is-your-neti-pot-safe-1.ece" mce_href="http://www.dallasnews.com/health/headlines/20120423-dallas-doctors-weigh-in-is-your-neti-pot-safe-1.ece">neti pot</a> safe? (Dallas News)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Acanthamoeba</span> keratitis <a target="_blank" href="http://www.cdc.gov/parasites/acanthamoeba/health_professionals/acanthamoeba_keratitis_hcp.html" mce_href="http://www.cdc.gov/parasites/acanthamoeba/health_professionals/acanthamoeba_keratitis_hcp.html">fact sheet</a> (CDC)</li> <li><a target="_blank" href="index.php?option=com_content&view=article&id=1184:twip-39-letters&catid=102:twip-letters&Itemid=267" mce_href="index.php?option=com_content&view=article&id=1184:twip-39-letters&catid=102:twip-letters&Itemid=267">Letters read</a> on TWiP 39</li> </ul> <h3 style="font-family: 'Lucida Grande'; font-size: medium;">Contact</h3> <p><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</span></p> <div><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"><br /></span></div>
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TWiP 38: How to Trichomonas
<p style="font-family: Verdana; font-size: medium;">Hosts: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" mce_href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org" mce_href="http://www.trichinella.org">Dickson Despommier</a></p> <p style="font-family: Verdana; font-size: medium;">Vincent and Dickson <span><span>tackle the backlog of listener email, then consider the life cycle and pathogenesis of </span></span><span><span><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Trichomonas vaginalis</span></span></span><span><span>, the flagellated protozoan transmitted by sexual contact.</span></span></p> <h3 style="font-family: Verdana; font-size: medium;">Links for this episode:</h3> <ul style="font-family: Verdana; font-size: medium;"> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">T. vaginalis</span> <a target="_blank" href="images/stories/twip/tvaginalis_cycle.jpg" mce_href="images/stories/twip/tvaginalis_cycle.jpg">life cycle</a> (jpg)</li> <li><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">T. vaginalis</span> <a target="_blank" href="images/stories/twip/hydrogenosome.jpg" mce_href="images/stories/twip/hydrogenosome.jpg">hydrogenosome</a> (jpg)</li> <li><a target="_blank" href="index.php?option=com_content&view=article&id=1166:twip-38-letters&catid=102:twip-letters&Itemid=267" mce_href="index.php?option=com_content&view=article&id=1166:twip-38-letters&catid=102:twip-letters&Itemid=267">Letters read</a> on TWiP 38</li> </ul> <h3 style="font-family: Verdana; font-size: medium;">Contact</h3> <p><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">Send your questions and comments (email or mp3 file) to twip@twiv.tv.</span></p>
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TWiP 37: Dracunculiasis
<div style="background-color: transparent; font-family: Verdana; font-size: medium;"> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent and Dickson discuss the life cycle and pathogenesis of </span><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Dracunculus medinensis</span><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">, the filarial nematode that causes dracunculiasis, or Guinea worm disease.</span></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" data-mce-style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"></span></p> <h3 style="font-family: 'Lucida Grande'; white-space: normal; font-size: medium;"><span style="font-size: medium;">Links for this episode:</span></h3> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" data-mce-style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"></span></p> <ul style="font-family: 'Lucida Grande'; white-space: normal; font-size: medium;"> <li><span style="font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Dracunculus</span> <a target="_blank" href="images/stories/twip/d_medinensis.jpg" mce_href="images/stories/twip/d_medinensis.jpg">emerging from foot</a> (jpg)</span></li> <li><span style="font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Dracunculus medinensis</span> <a target="_blank" href="images/stories/twip/dracunculus.jpg" mce_href="images/stories/twip/dracunculus.jpg">life cycle</a> (jpg)</span></li> <li><span style="font-size: medium;"><a href="http://www.who.int/topics/dracunculiasis/en/" mce_href="http://www.who.int/topics/dracunculiasis/en/" target="_blank">Guinea worm</a> - WHO</span></li> <li><span style="font-size: medium;"><a href="http://www.cartercenter.org/health/guinea_worm/mini_site/index.html" mce_href="http://www.cartercenter.org/health/guinea_worm/mini_site/index.html" target="_blank">Guinea worm eradication</a> - The Carter Center</span></li> <li><span style="font-size: medium;">War against <a href="http://www.youtube.com/watch?v=eG1By-CEXrw" mce_href="http://www.youtube.com/watch?v=eG1By-CEXrw " target="_blank">Guinea worm</a> (YouTube)</span></li> <li><span style="font-size: medium;"><a href="http://drblayney.com/Asclepius.html" mce_href="http://drblayney.com/Asclepius.html" target="_blank">Caduceus vs staff of Asclepius</a></span></li> <li><span style="font-size: medium;">Vincent and Dickson - <a target="_blank" href="http://www.twiv.tv/v&d_dogs.png" mce_href="http://www.twiv.tv/v&d_dogs.png">the dogs</a> (jpg)</span></li> <li><span style="font-size: medium;"><a href="index.php?option=com_content&view=article&id=1135" mce_href="index.php?option=com_content&view=article&id=1135" target="_blank">Letters read</a> on TWiP 37</span></li> </ul> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 13px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"></span></p> </div>
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TWiP 36: Trichuris and microbes plan a hatch
<p><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;">Vincent and Dickson review how gut bacteria help establish</span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"><i>T. muris</i></span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;">in the large intestine of mice.</span></p>
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TWiP 35: Malaria control with David Fidock
<p><span style="font-size: medium;"><span class="Apple-style-span" style="font-family: Verdana;">Vincent and Dickson discuss control of malaria with their Columbia University colleague </span><span class="Apple-style-span" style="font-family: Verdana;"><a target="_blank" href="http://www.microbiology.columbia.edu/faculty/fidock.html" mce_href="http://www.microbiology.columbia.edu/faculty/fidock.html">David Fidock</a></span><span class="Apple-style-span" style="font-family: Verdana;">.</span></span></p>
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TWiP #34 - Up against the Wolbachia
<p><span style="font-size: medium;"><span class="Apple-style-span" style="font-family: Verdana;">Vincent and Dickson discuss control of malaria and filariasis with the bacterial endosymbiont </span><span class="Apple-style-span" style="font-family: Verdana;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Wolbachia</span></span><span class="Apple-style-span" style="font-family: Verdana;">.</span></span></p>
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TWiP #33 - Hide and seek
<p><span style="font-size: medium;"><span class="Apple-style-span" style="font-family: Verdana;">Vincent and Dickson review an</span><span class="Apple-style-span" style="font-family: Verdana;"> </span><span class="Apple-style-span" style="font-family: Verdana;"><i>in silico</i></span><span class="Apple-style-span" style="font-family: Verdana;"> </span><span class="Apple-style-span" style="font-family: Verdana;">pipeline for identifying molecular mimicry candidate proteins in the genomes of parasites, and catch up on listener email.</span></span></p>
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TWiP #32: Evasive trypanosomes and schistosomes
<p><span style="font-size: medium;"><span class="Apple-style-span" style="font-family: 'Lucida Grande';">Vincent and Dickson discuss immune evasion by the cruzain protease of</span><span class="Apple-style-span" style="font-family: 'Lucida Grande';"> </span><span class="Apple-style-span" style="font-family: 'Lucida Grande';"><i>T. cruzi</i></span><span class="Apple-style-span" style="font-family: 'Lucida Grande';">, and novel tetraspanin antigens of</span><span class="Apple-style-span" style="font-family: 'Lucida Grande';"> </span><span class="Apple-style-span" style="font-family: 'Lucida Grande';"><i>S. japonicum</i></span><span class="Apple-style-span" style="font-family: 'Lucida Grande';">.</span></span></p>
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TWiP #31 - A malaria vaccine
<p><span class="Apple-style-span" style="font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; line-height: 19px; font-size: medium;">Vincent and Dickson discuss the promising results of a phase III trial of a malaria vaccine in African children.</span></p>
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TWiP #30 - Global infectious disease control with Charles Knirsch
<p><span style="font-size: medium;">Vincent and Dickson have a broad-ranging conversation with Charles Knirsch of Pfizer, Inc. about how public-private partnerships can function to control and eliminate infectious diseases.</span></p>
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TWiP #29 - Neglected tropical diseases with Peter Hotez
<p><span style="font-size: medium;">Vincent and Dickson converse with <a target="_blank" href="http://en.wikipedia.org/wiki/Peter_Hotez">Peter Hotez</a> about global health, vaccinology, and neglected tropical diseases.</span></p>
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TWiP #28 - Medical entomology with Robert W. Gwadz
<p><span style="font-size: medium;">Vincent and Dickson discuss medical entomology with Robert W. Gwadz, Assistant Chief of the Laboratory of Malaria and Vector Research at NIAID.</span></p>
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TWiP #27 - Trematodes
<p><span style="font-size: medium;">Vincent and Dickson continue their discussion of trematodes, or flukes, which have a snail as a reservoir host.</span></p>
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TWiP #26 - The schistosomes
<p><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.</span></p>
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TWiP #25 - Wuchereria bancrofti
<p><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">Vincent and Dickson review </span><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Wuchereria bancrofti</span></span><span class="Apple-style-span" style="font-family: Verdana; font-size: medium;">, the nematode that causes lymphatic filariasis, also known as elephantiasis.</span></p>
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TWiP #24 - Onchocerca volvulus, a vector-borne, filarial nematode
<p><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;">Vincent and Dickson discuss the life cycle and pathogenesis of</span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;"><span class="Apple-style-span" style="font-style: italic;">Onchocerca volvulus, </span></span><span class="Apple-style-span" style="font-family: 'Lucida Grande'; font-size: medium;">the vector-borne filarial nematode parasite that causes onchocerciasis, or river blindness.</span></p>
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TWiP #23 - Strongyloides sterocoralis, a most unusual parasite
<p>Vincent and Dickson review the life cycle and pathogenesis of the world's most unusual parasite, <em>Strongyloides stercoralis</em>.</p>
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TWiP #22 - Hookworm
<p><span style="font-family: Helvetica, Arial, FreeSans, sans-serif; line-height: 16px;">Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm <em style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; background-position: initial initial; background-repeat: initial initial; padding: 0px; margin: 0px; border: 0px initial initial;">Ancylostoma duodenale</em> and <em style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; background-position: initial initial; background-repeat: initial initial; padding: 0px; margin: 0px; border: 0px initial initial;">Necator americanus</em>.</span></p>
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TWiP #21 - The giant intestinal worm, Ascaris lumbricoides
<p><span style="font-family: Verdana; font-size: medium;">Vincent and Dickson review the biology and pathogenesis of</span><span style="font-family: Verdana; font-size: medium;"> </span><span style="font-family: Verdana; font-size: medium;"><span style="font-style: italic;">Ascaris lumbricoides</span></span><span style="font-family: Verdana; font-size: medium;">, one of the largest nematodes to infect humans.</span></p>
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TWiP #20 - The whipworm Trichuris trichiura
<p>Vincent and Dickson continue their discussion of nematodes with the whipworm <em>Trichuris trichiura</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Trichuris trichiura </em><a href="images/stories/twip/t_trichiura_adult_female.jpg" target="_blank">adult female</a> (jpg)</li> <li><em> Trichuris trichiura </em><a href="images/stories/twip/t_trichuris_adult_male.jpg" target="_blank">adult male</a><span> (jpg)</span></li> <li><span><em> Trichuris trichiura </em><em><a href="images/stories/twip/trichuris_in_situ.jpg" target="_blank">in situ</a></em><span> (jpg)</span></span></li> <li><span><span> <em>Trichuris trichiura</em> </span><a href="images/stories/twip/trichuris_trichiura_lifecycle.jpg" target="_blank">life cycle</a><span> (jpg)</span></span></li> <li><span><span>Exploitation of the <a href="http://www.ncbi.nlm.nih.gov/pubmed/20538949" target="_blank">intestinal microflora</a> by <em>T. muris</em></span></span></li> <li><span style="font-weight: normal;"><a href="index.php?option=com_content&view=article&id=830:twip-20-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters read</a></span> on TWiP 20</li> </ul> <ul> </ul> <ul> </ul> <h3>Contact</h3> <p>Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3><strong>Subscribe (free)</strong></h3> <p>Click <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US">here</a> to receive an email notification when a new episode of TWiP is published</p>
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TWiP #19 - Enterobius vermicularis, the pinworm
<p>Vincent and Dickson move on to nematodes with a discussion of the pinworm <em>Enterobius vermicularis</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Enterobius vermicularis </em><a href="images/stories/twip/adult_female_enterobius_vermicularis_h.jpg" target="_blank">adult female</a> (jpg)</li> <li><em>Enterobius vermicularis </em><a href="images/stories/twip/adult_e_vermicularis_appendix.jpg" target="_blank">in appendix</a><span> (jpg)</span></li> <li><span><em>Enterobius vermicularis </em><a href="images/stories/twip/e_vermicularis_embryonated_eggs.jpg" target="_blank">embryonated eggs</a><span> (jpg)</span></span></li> <li><span><em>Enterobius vermicularis</em><span> </span><a href="images/stories/twip/enterobius_vermicularis_life_cycle.jpg" target="_blank">life cycle</a><span> (jpg)</span></span></li> <li><span style="font-weight: normal;"><a href="index.php?option=com_content&view=article&id=812" target="_blank">Letters read</a></span> on TWiP 19</li> </ul> <ul> </ul> <ul> </ul> <h3>Contact</h3> <p>Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3><strong>Subscribe (free)</strong></h3> <p>Click <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US">here</a> to receive an email notification when a new episode of TWiP is published.</p>
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TWiP #18 - Cryptosporidium
<p>Vincent and Dickson discuss the intracellular parasite <em>Cryptosporidium,</em> which causes diarrheal disease in most mammalian species.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Cryptosporidium parvum</em> <a href="images/stories/twip/c_parvum.jpg" target="_blank">electron micrograph</a> (jpg)</li> <li><em>Cryptosporidium parvum </em><span><a href="images/stories/twip/c_parvum_meronts.jpg" target="_blank">meronts</a> (jpg)</span></li> <li><span><em>Cryptosporidium parvum</em><span> <a href="images/stories/twip/c_parvum_lifecycle.jpg" target="_blank">life cycle</a> (jpg)</span></span></li> <li><span><span><em><a href="http://www.cdc.gov/crypto/" target="_blank">Cryptosporidium </a><a href="http://www.cdc.gov/crypto/" target="_blank"><span style="font-style: normal;">page</span></a></em> at CDC</span></span></li> <li><span style="font-weight: normal;"><a href="index.php?option=com_content&view=article&id=799" target="_blank">Letters read</a></span> on TWiP 18</li> </ul> <ul> </ul> <ul> </ul> <h3>Contact</h3> <p>Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3><strong>Subscribe (free)</strong></h3> <p>Click <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US">here</a> to receive an email notification when a new episode of TWiP is published.</p>
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TWiP #17 - Entamoeba histolytica
<p>Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by <em>Entamoeba histolytica</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Entamoeba histolytica</em> <a href="images/stories/twip/e_histolytica_cyst.png" target="_blank">cyst</a> (jpg)</li> <li><em>Entamoeba histolytica</em> <a href="images/stories/twip/e_histolytica_trophozoite.png" target="_blank">trophozoite</a> (jpg)</li> <li><em>Entamoeba histolytica</em> <a href="images/stories/twip/e_histolytica_life_cycle.jpg" target="_blank">life cycle</a> (jpg)</li> <li><a href="images/stories/twip/galactose_blocks_amebae.png" target="_blank">Galactose prevents attachment</a> of amoebae to cells (jpg)</li> <li><em>Entamoeba histolytica</em> life cycle (jpg)</li> <li><a href="images/stories/twip/charcot_leyden_crystal.png" target="_blank">Charcot-Leyden crystal</a> (jpg)</li> <li><a href="index.php?option=com_content&view=article&id=771" target="_blank"><span style="font-weight: normal;">Letters read</span></a> on TWiP 17</li> </ul> <ul> </ul> <ul> </ul> <h3>Contact</h3> <p>Send your questions and comments (email or mp3 file) to twip@twiv.tv.</p> <h3><strong>Subscribe (free)</strong></h3> <p>Click <a href="http://feedburner.google.com/fb/a/mailverify?uri=parasitism&loc=en_US">here</a> to receive an email notification when a new episode of TWiP is published.</p>
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TWiP #16: Giardia
<p>Vincent and Dickson review the life cycle and pathogenesis of the flagellated protozoan parasite <em>Giardia lamblia</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Giardia lamblia</em> <a href="http://www.microbeworld.org/images/stories/twip/giardia_lamblia_trophozoite.jpg" target="_blank">trophozoite</a> (jpg)</li> <li><em>Giardia lamblia</em> <a href="http://www.microbeworld.org/images/stories/twip/giardia_lamblia_cyst.jpg" target="_blank">cyst</a> (jpg)</li> <li><em>Giardia lamblia</em> <a href="http://www.microbeworld.org/images/stories/twip/giardia_lamblia_lifecycle.jpg" target="_blank">life cycle</a> (jpg)</li> <li><a href="http://www.twiv.tv/T_canis_T_cati_life_cycle.pdf" target="_blank">Heather's view</a> of <em>T. canis</em> life cycle (pdf)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=771" target="_blank"><span style="font-weight: normal;">Letters read</span></a> on TWiP 16</li> </ul>
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TWiP #15: Tryp the light fantastic
<p>Vincent and Dickson discuss the life cycle and pathogenesis of the protozoan parasite <em>Trypanosoma</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <li><a href="http://microbeworld.org/images/stories/twip/metacyclic_trypanomastigote.jpg" target="_blank">Metacyclic trypanomastigote</a> (jpg)</li> <li><a href="http://microbeworld.org/images/stories/twip/tsetse_fly.jpg" target="_blank">Tsetse fly </a> (jpg)</li> <li><a href="http://microbeworld.org/images/stories/twip/t_brucei_lifecycle.jpg" target="_blank"><em>T. brucei</em> life cycle</a> (jpg)</li> <li><a href="http://microbeworld.org/images/stories/twip/t_brucei_parasitemia.jpg" target="_blank"><em>T. brucei</em> parasitemia </a>(jpg)</li> <li><a href="http://microbeworld.org/images/stories/twip/kissing_bug_nymph.jpg" target="_blank">Kissing bug nymph </a>(jpg)</li> <li><a href="http://microbeworld.org/images/stories/twip/t_cruzi_lifecycle.jpg" target="_blank"><em>T. cruzi</em> life cycle </a>(jpg)</li> <li><span style="font-weight: normal;"><a href="http://microbeworld.org/index.php?option=com_content&view=article&id=726:twip-15-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters read</a></span><span style="font-weight: normal;"> on TWiP 15</span></li>
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TWiP #14 - Leishmania
<p>Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite <em>Leishmania</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <p><a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg"> </a></p> <div class="article-content"> <li><em>L. braziliensis</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/l_braziliensis.jpg" target="_blank">jpg</a>)</li> <li><em>L. donovani</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/l_donovani.jpg" target="_blank">jpg</a>)</li> <li><em>L. tropica</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/l_tropica.jpg" target="_blank">jpg</a>)</li> <li><em>L. major</em> lesion (<a href="http://www.microbeworld.org/images/stories/twip/l_major_lesion.jpg" target="_blank">jpg</a>)</li> <li>Transgenic mosquito delivers <em><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2583.2010.01000.x/abstract" target="_blank">Leishmania</a></em><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2583.2010.01000.x/abstract" target="_blank"> vaccine</a> (thanks, Geoffrey)</li> <li><em>Plasmodium falciparum</em> <a href="http://www.cell.com/current-biology/retrieve/pii/S0960982210006573" target="_blank">accompanied human expansion</a> out of Africa (thanks, Prasad)</li> <li>Who speaks for the <a href="http://www.deadlysins.com/guineaworm/foundation.htm" target="_blank">guinea worm</a>? (thanks, Michael)</li> <li><span style="font-weight: normal;"><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=713" target="_blank">Letters read</a></span><span style="font-weight: normal;"> on TWiP 14</span></li> </div>
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TWiP #13 - Toxoplasmosis
<p>Vincent and Dickson continue their discussion of the obligate intracellular protozoan <em>Toxoplasma gondii</em> with a consideration of the clinical consequences of infection and pathogenesis.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <p><a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg"> </a></p> <div class="article-content"> <li>Isopod <a href="http://www.idosi.org/wjfms/wjfms1%282%2909/10.pdf" target="_blank">fish parasites</a> (thanks, Kevin!)</li> <li><a href="http://www.wordspy.com/words/farmscraper.asp" target="_blank">Farmscraper</a> on Word Spy (thanks, Mitchell!)</li> <li>Toxoplasma and <a href="http://mblogs.discovermagazine.com/loom/2006/08/01/a-nation-of-neurotics-blame-the-puppet-masters/" target="_blank">personalities</a> (thanks, Greg!)</li> <li><a href="http://www.sciencemag.org/about/podcast.dtl" target="_blank">Science podcast</a> (July 2) on parasites and intelligence (<a href="http://www.sciencemag.org/cgi/content/full/329/5987/97-b/DC1" target="_blank">transcript</a> - thanks, Jim!)</li> <li><span style="font-weight: normal;"><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=692" target="_blank">Letters read</a></span><span style="font-weight: normal;"> on TWiP 13</span></li> </div>
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TWiP #12 - Toxoplasma gondii
<p>Vincent and Dickson introduce the obligate intracellular protozoan <em>Toxoplasma gondii</em>, one of the most successful parasites on earth.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <p><a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg"> </a></p> <div class="article-content"> <li>Global clinical burden of malaria (<a href="http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000290" target="_blank">PLoS Medicine</a>)</li> <li><em>T. gondii</em> sporulated oocysts (<a href="http://www.microbeworld.org/images/stories/twip/t_gondii_oocyst.jpg" target="_blank">jpg</a>)</li> <li><span style="font-weight: normal;"><em>T. gondii</em> tachyzoites in parasitophorous vacuole (<a href="http://www.microbeworld.org/images/stories/twip/t_gondii_tachyzoite.jpg" target="_blank">jpg</a></span><span style="font-weight: normal;">)</span></li> <li><em>T. gondii</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/t_gondii_cycle.jpg" target="_blank">jpg</a>)</li> <li><a href="http://news.ufl.edu/2010/05/12/insect-terrorism/" target="_blank">Insect bioterrorism conference</a> (thanks, Don!)</li> <li><a href="http://dailyparasite.blogspot.com/" target="_blank">Parasite of the Day</a> (thanks, Douglas!)</li> <li><a href="http://www.worldsciencefestival.com/" target="_blank">World Science Festival</a></li> <li><span style="font-weight: normal;"><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=675" target="_blank">Letters read</a></span><span style="font-weight: normal;"> on TWiP 12</span></li> </div>
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TWiP #11 - One times three million
<p>Vincent and Dickson continue their discussion of malaria, with emphasis on clinical aspects of the disease.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <p><a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg"> </a></p> <div class="article-content"> <li><span style="font-weight: normal;">The quest for a malaria vaccine<a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg"> (</a></span><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=640:mts49-irwin-sherman-the-quest-for-a-malaria-vaccine&catid=37:meet-the-scientist&Itemid=155" target="_blank"><span style="font-weight: normal;">Meet the Scientist 49</span></a><span style="font-weight: normal;">)</span></li> <li><span style="font-weight: normal;">Science issue on </span><a href="http://www.sciencemag.org/content/vol328/issue5980/index.dtl" target="_blank"><span style="font-weight: normal;">malaria and tuberculosis</span></a></li> <li><span style="font-weight: normal;">Malaria pathogenesis (</span><a href="http://www.sciencemag.org/feature/data/diseases/PDFs/264-5167-1878.pdf" target="_blank"><span style="font-weight: normal;">pdf</span></a><span style="font-weight: normal;">)</span></li> <li>Malaria pathogenesis (<a href="http://www.microbeworld.org/images/stories/twip/malaria_pathogenesis.jpg" target="_blank">jpg</a>)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=667" target="_blank"><span style="font-weight: normal;">Letters read</span></a><span style="font-weight: normal;"> on TWiP 11</span></li> </div>
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TWiP #10 - Plasmodium life cycle
<p>Vincent and Dickson trace the life cycle of <em>Plasmodium</em> in a mosquito and in a human host.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li>Mosquito cycle - sporogany (<a href="http://www.microbeworld.org/images/stories/twip/mosquito_cycle.jpg" target="_blank">jpg</a>)</li> <li><em>Plasmodium falciparum</em> cycle (<a href="http://www.microbeworld.org/images/stories/twip/falciparum_cycle.jpg" target="_blank">jpg</a>)</li> <li><em>Plasmodium vivax</em> cycle (<a href="http://www.microbeworld.org/images/stories/twip/vivax_cycle.jpg" target="_blank">jpg</a>)</li> <li><em>Plasmodium falciparum</em> ring forms and gametocytes in blood (<a href="http://www.microbeworld.org/images/stories/twip/plasmodium_blood.jpg" target="_blank">jpg</a>)</li> <li><em>Plasmodium</em> stages (<a href="http://www.microbeworld.org/images/stories/twip/falciparum_stages.jpg" target="_blank">jpg</a>)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=652" target="_blank">Letters read</a> on TWiP 10</li> </ul>
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TWiP #9 - Mala aria
<p>Vincent and Dickson move on to protozoan parasites with a discussion of the early history of malaria.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><a href="http://www.cdc.gov/malaria/history/index.htm" target="_blank">Malaria history</a> at CDC</li> <li>Radio New Zealand <a href="http://www.radionz.co.nz/national/programmes/ourchangingworld/20100401" target="_blank">show on hookworms</a> (thanks James!)</li> <li>Tapeworm brain infection <a href="http://esciencenews.com/articles/2010/04/14/tapeworm.brain.infection.serious.health.concern" target="_blank">serious health concern</a> (thanks Jim!)</li> <li>Pig farmers try to limit <a href="http://www.nytimes.com/2010/04/20/health/20global.html?emc=eta1" target="_blank">pork tapeworm spread</a> (thanks Gopal!)</li> <li>Bizarre tongue-eating <a href="http://www.treehugger.com/files/2009/09/tongue-eating-parasite-discovered.php" target="_blank">fish parasite</a> (thanks Arsen!)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=642" target="_blank">Letters read</a> on TWiP 9</li> </ul>
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TWiP #8 - Frog legs and parasite tales
<p>Dickson reads his story about sparganosis caused by the diphyllobothroid tapeworm <em>Spirometra mansonoides</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Spirometra</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/sparganosis_lifecycle.gif" target="_blank">jpg</a>)</li> <li>Dickson on vertical farming (<a href="http://www.youtube.com/watch?v=5uLTOMsF3uU&feature=email" target="_blank">CNN episode on YouTube</a>, thanks Jesse!)</li> <li>Laboratory identification of parasites (<a href="http://www.dpd.cdc.gov/dpdx/Default.htm" target="_blank">CDC</a>, thanks Michael!)</li> <li>Gold nanoparticles take out brain parasite (<a href="http://www.cosmosmagazine.com/news/3345/gold-nanoparticles-take-out-brain-parasite?page=0%2C1" target="_blank">Cosmos Magazine</a>, thanks Gary!)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=631:twip-8-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters read</a> on TWiP 8</li> </ul> <p><img src="http://feeds.feedburner.com/~r/parasitism/~4/bPT93dboZX8" alt="" width="1" height="1" /></p>
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TWiP #7 - Tapeworms are fantastic!
<p>Vincent and Dickson continue their discourse on tapeworms, covering the fish and dog varieties.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li>FAT the enemy that is shortening your life is BANISHED. How? With sanitized tapeworms. Easy to swallow! (<a href="http://www.microbeworld.org/images/stories/twip/tapeworms.jpg" target="_blank">jpg</a>).</li> <li><em>D. latum</em> life cycle (<a href="http://www.microbeworld.org/images/stories/twip/d_latum_lifecycle.gif" target="_blank">jpg</a>)</li> <li><em>D. latum</em> adult (<a href="http://www.microbeworld.org/images/stories/twip/d_latum.jpg" target="_blank">jpg</a>)</li> <li><em>Diphyllobothrim</em> proglottid (<a href="http://www.microbeworld.org/images/stories/twip/diphyllobothrim_proglottid.jpg" target="_blank">jpg</a>)</li> <li><em>Diphyllobothrim</em> bothria (<a href="http://www.microbeworld.org/images/stories/twip/diphyllobothrim_bothria.jpg" target="_blank">jpg</a>)</li> <li>Coracidium hatching from egg (<a href="http://www.microbeworld.org/images/stories/twip/coracidium.jpg" target="_blank">jpg</a>)</li> <li>Dog tapeworm life cycle (<a href="http://www.microbeworld.org/images/stories/twip/dog_tapeworm_cycle.gif" target="_blank">jpg</a>)</li> <li>The Alien lifecycle (<a href="http://www.microbeworld.org/images/stories/twip/alien_life_cycle_by_kronosthemad.jpg" target="_blank">jpg</a>)</li> </ul>
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TWiP #6 - Tapeworms, the long and short of it
<p>Vincent and Dick talk about the anatomy and life cycle of beef and pork tapeworms, and why <a href="http://en.wikipedia.org/wiki/Pilot_%28House%29" target="_blank">House</a> was wrong about neurocysticercosis.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>Taenia saginata</em> life cycle <a href="http://www.microbeworld.org/images/stories/twip/t_saginata_cycle.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia saginata</em> adult <a href="http://www.microbeworld.org/images/stories/twip/t_saginata_adult.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia saginata</em> scolex <a href="http://www.microbeworld.org/images/stories/twip/t_saginata_scolex.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia saginata</em> gravid proglottid <a href="http://www.microbeworld.org/images/stories/twip/t_saginata_gravid_proglottid.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia solium</em> life cycle <a href="http://www.microbeworld.org/images/stories/twip/t_solium_cycle.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia solium</em> adult <a href="http://www.microbeworld.org/images/stories/twip/t_solium_adult.jpg" target="_blank">(jpg)</a></li> <li><em>Taenia solium</em> scolex <a href="http://www.microbeworld.org/images/stories/twip/t_solium_scolex.jpg" target="_blank">(jpg)</a></li> <li>Facial cancer in <a href="http://www.nytimes.com/2010/01/01/science/01devil.html?hpw" target="_blank">Tasmanian devils</a> (thanks PhogDog!)</li> </ul> <p><strong>Science Picks</strong></p> <p><strong>Dickson </strong><em><a href="http://www.sciencemag.org/cgi/content/summary/sci;327/5971/1301?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=hotez&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT" target="_blank">Peace through vaccine diplomacy</a></em> by Peter Hotez<br /><strong>Vincent</strong> <em><a href="http://astore.amazon.com/virologyws-20" target="_blank">Parasite Rex</a></em> by Carl Zimmer</p> <h3></h3>
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TWiP #5 - The nurse cell
<p>Vincent and Dick discuss the nurse cell, a unique structure formed in the host muscle by <em>Trichinella</em> species.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li>Infective muscle larva (<a href="http://www.microbeworld.org/images/stories/twip/infective-muscle-larva.gif">jpg</a>)</li> <li>Schematic of a larva <a href="http://www.trichinella.org/bio_nursecell.htm" target="_blank">invading a muscle cell</a></li> <li>Nurse cell formation (<a href="http://www.trichinella.org/bio_nursecell.htm" target="_blank">scroll down the page</a>)</li> <li>Dickson's <a href="http://www.trichinella.org/gallery/The-Trichinella-Gallery.html" target="_blank">gallery</a> of Trichinella images</li> <li>Electron micrographs of <a href="http://www.trichinella.org/gallery/The-Trichinella-Gallery.html" target="_blank">stichocytes</a></li> </ul> <p><strong>Weekly Science Picks</strong></p> <p><strong>Dickson </strong><em><a href="http://astore.amazon.com/virologyws-20" target="_blank">Every Living Thing</a></em> by Rob Dunn<strong><br /></strong></p>
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TWiP #4 - Trichinella life cycle
<p>Vincent and Dick trace the life cycle of <em>Trichinella spiralis</em> in an infected host.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><a class="jcebox" title="Trichinella life cycle" href="http://www.microbeworld.org/images/stories/twip/lifecycle.gif" target="_blank"><span style="float: right; margin: 5px;"></span></a>Trichinella life cycle <a class="jcepopup" title="Trichinella life cycle" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/lifecycle.gif"><span class="zoom-link">(jpg)</span></a></li> <li>Newborn larva entering muscle cell <a class="jcepopup" title="Newborn larva entering muscle cell" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/newborn_enters_muscle.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Adult <em>T. spiralis</em> in columnar epithelial cell <a class="jcepopup" title="Adult T. spiralis in columnar epithelial cell" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/adult_intestine.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Adult female <em>T. spiralis</em> <a class="jcepopup" title="Adult female T. spiralis" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/female_columnar_epithelium.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Infective first stage <em>T. spiralis</em> larva in Nurse cell in muscle tissue <a class="jcepopup" title="Infective first stage T. spiralis larva in Nurse cell in muscle tissue" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/first_stage_nurse.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Adult female <em>T. spiralis</em> with fully formed larvae in uterus <a class="jcepopup" title="Adult female T. spiralis with fully formed larvae in uterus" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/female_larvae.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Adult male <em>T. spiralis</em> with claspers on tail <a class="jcepopup" title="Adult male T. spiralis with claspers on tail" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/male_claspers.jpg"><span class="zoom-link">(jpg)</span></a></li> <li>Clinical correlations in trichinosis <a class="jcepopup" title="Clinical correlations in trichinosis" rel="group[twip04]" href="http://www.microbeworld.org/images/stories/twip/clinical_corr_trichinella.gif"><span class="zoom-link">(jpg)</span></a></li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=577:twip-4-letters&catid=102:twip-letters&Itemid=267" target="_blank">Letters</a> read on TWiP #4</li> </ul> <h3>Weekly Science Picks</h3> <p><strong>Dickson </strong><strong><span style="font-weight: normal;"><a href="http://www.scharfphoto.com/" target="_blank">David Scharf's pictures of microbial life</a></span><br />Vincent </strong><a href="http://www.lindau-nobel.de/WebHome.AxCMS" target="_blank">The Nobel Laureate Meetings at Lindau</a></p>
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TWiP #3 - Trichinella spiralis
<p>Vincent and Dick distinguish among intracellular and extracellular parasites, then discuss the history and general characteristics of <em>Trichinella spiralis</em>.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3>Links for this episode:</h3> <ul> <li><em>The History of Trichinella</em> at <a href="http://www.trichinella.org/history.htm" target="_blank">Trichinella.org</a></li> <li>Parasite <a href="http://www.ebi.ac.uk/parasites/parasite-genome.html" target="_blank">genome databases</a> at the European Bioinformatics Institute</li> <li>List of <a href="http://www.pasteur.fr/recherche/unites/tcruzi/minoprio/genomics/parasites.htm" target="_blank">parasite genome projects</a></li> </ul> <h3>Weekly Science Picks</h3> <p><strong>Dickson</strong> <em><a href="http://astore.amazon.com/virologyws-20" target="_blank">The Doctor and the Devils</a></em></p>
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TWiP #2 - General parasitism
<p>Vincent and Dick classify parasites according to whether or not they are transmitted by a vector, then consider the implications of long-lived parasites.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p>
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TWiP #1 - Introduction to parasitism
<p>Vincent and Dick provide an overview of parasites and parasitism.</p> <p>Host links: <a href="http://en.wikipedia.org/wiki/Vincent_Racaniello" target="_blank">Vincent Racaniello</a> and <a href="http://www.trichinella.org/">Dickson Despommier</a></p> <h3><strong>Weekly Science Picks</strong></h3> <p>Dick <a href="http://astore.amazon.com/virologyws-20" target="_blank"><em>T</em></a><a href="http://astore.amazon.com/virologyws-20"><em>he Black Cloud</em></a> by Fred Hoyle<br />Vincent <em><a href="http://www.apple-trees.com/">Parasitic Diseases</a></em> by Despommier et al.</p>
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