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Description:

This Week in Microbiology (TWiM) is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. An informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.

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Podcast Episode's:
TWiM #166: Dark fermentation
<p>Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank" rel= "noopener">Vincent Racaniello</a> and <a href= "http://schaechter.asmblog.org/" target="_blank" rel= "noopener">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener">ASM Podcast app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiM. <a class="jcepopup" href="images/Communications/images/Fuelcell.jpg" target="_blank" rel="noopener"><img style="margin: 2px; float: right;" src= "images/Communications/images/Fuelcell.jpg" alt="Fuel cell" width= "300" height="236" /></a></p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://www.pnas.org/content/114/47/12578.abstract">Glycosylation site</a> on influenza H3N2 viruses (PNAS)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://www.sciencedirect.com/science/article/pii/S0956053X17307110?via%3Dihub"> Biohydrogen production</a> by Thermotoga (Waste Man)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://commons.wikimedia.org/wiki/File:Fuelcell.jpg">Image credit</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "index.php/podcasts/twim/twim-letters/item/6992-twim-166-letters" target="_blank" rel="noopener">Letters read on TWiM 166</a></p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv</p>
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TWiM #165: Pumping Copper
<p><span style="font-weight: 400;">The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system.</span></p> <p><span style="font-weight: 400;">Hosts: <a href= "http://www.virology.ws">Vincent Racaniello</a>, Elio Schaechter, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html"> Michael Schmidt</a>, and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a></span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><a href= "https://doi.org/10.1016/j.ajic.2017.08.028"><span style= "font-weight: 400;">Reducing bacteria</span></a> <span style= "font-weight: 400;">on exercise weights with copper (Am J Inf Contr)</span></li> <li style="font-weight: 400;"><a href= "http://mbio.asm.org/content/8/6/e01470-17.full"><span style= "font-weight: 400;">Antigenic variation</span></a> <span style= "font-weight: 400;">in</span> <em><span style= "font-weight: 400;">Pneumocystis jirovecii</span></em> <span style= "font-weight: 400;">(mBio)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Letters read on TWiM 165</span></li> </ul>
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TWiM #164: Indiana Quorum
<p><span style="font-weight: 400;">From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria.</span></p> <p><span style="font-weight: 400;">Guests: <a href= "https://biology.indiana.edu/about/faculty/dalia-ankur.html">Ankur Dalia</a>, <a href= "https://biology.indiana.edu/about/faculty/van-kessel-julia.html">Julia Van Kessel</a>, and <a href= "https://biology.indiana.edu/about/faculty/wang-xindan.html">Xindan Wang</a></span></p> <p><span style="font-weight: 400;">Watch the video version! <a href="https://www.youtube.com/watch?v=ifGCe-qfnA0">https://www.youtube.com/watch?v=ifGCe-qfnA0</a></span></p> <p><span style="font-weight: 400;">Become a</span> <a href= "http://www.microbe.tv/contribute"><span style= "font-weight: 400;">patron</span></a> <span style= "font-weight: 400;">of TWiM.</span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><a href= "https://biology.indiana.edu/about/faculty/dalia-ankur.html"><span style="font-weight: 400;"> Dalia</span></a> <span style= "font-weight: 400;">laboratory</span></li> <li style="font-weight: 400;"><a href= "https://biology.indiana.edu/about/faculty/van-kessel-julia.html"><span style="font-weight: 400;"> Van Kessel</span></a> <span style= "font-weight: 400;">laboratory</span></li> <li style="font-weight: 400;"><a href= "https://biology.indiana.edu/about/faculty/wang-xindan.html"><span style="font-weight: 400;"> Wang</span></a> <span style= "font-weight: 400;">laboratory</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Indiana U</span> <a href= "https://biology.indiana.edu/index.html"><span style= "font-weight: 400;">Dept of Biology</span></a></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Vibrio</span> <a href= "http://onlinelibrary.wiley.com/doi/10.1111/1462-2920.13302/abstract;jsessionid=E452735317DB7D16355E8EAC24A0D929.f03t01"> <span style="font-weight: 400;">DNA uptake and chitin</span></a> <span style="font-weight: 400;">(Environ Micro)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Activation of</span> <a href= "https://www.ncbi.nlm.nih.gov/pubmed/27191515"><span style= "font-weight: 400;">quorum-sensing genes</span></a> <span style= "font-weight: 400;">(Mol Micro)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28154080">Structural maintenance of chromosome</a> complexes (Science)</span></li> </ul>
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TWiM #163: Saliva and sptR/S
<p><span style="font-weight: 400;">This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation.</span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Genes for the</span> <em><span style="font-weight: 400;">Streptococcus pyogenes</span></em> <span style="font-weight: 400;">fitness in human saliva (mSphere)</span></li> <li style="font-weight: 400;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/29051379"><span style= "font-weight: 400;">Swallowed bacteria</span></a> <span style= "font-weight: 400;">drive colonic inflammation (Science)</span></li> <li style="font-weight: 400;"><a href= "http://science.sciencemag.org/content/358/6361/308"><span style= "font-weight: 400;">Intestinal inflammation</span></a> <span style= "font-weight: 400;">induced by oral bacteria (Science)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Human</span> <a href= "http://jb.asm.org/content/192/19/5002.abstract"><span style= "font-weight: 400;">oral microbiome</span></a> <span style= "font-weight: 400;">(J Bact)</span></li> <li style="font-weight: 400;"><a href= "https://www.nature.com/nri/posters/tcellsubsets/nri1009_tcellsubsets_poster.pdf"> <span style="font-weight: 400;">T cell subsets</span></a> <span style="font-weight: 400;">(Nat Rev Imm)</span></li> <li style="font-weight: 400;"><a href= "https://www.flickr.com/photos/niaid/13743456084"><span style= "font-weight: 400;">Image credit</span></a></li> </ul>
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TWiM #162: Intracellular bacteria with flagella
<p dir="ltr">The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank" rel= "noopener">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank" rel="noopener">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank" rel= "noopener">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Fungus killing <a href= "http://www.nature.com/nature/journal/v544/n7650/full/nature22059.html" target="_blank" rel="noopener">fire salamanders</a> (Nature)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Chlamydia with <a href= "http://www.nature.com/ismej/journal/v11/n10/full/ismej201795a.html?foxtrotcallback=true" target="_blank" rel="noopener">flagella</a> (ISME J)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087718" target="_blank" rel="noopener">Flagellar movement</a> in rickettsia (PLoS One)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://en.wikipedia.org/wiki/Fire_salamander#/media/File:Salamandra_salamandra_MHNT_1.jpg" target="_blank" rel="noopener">Image credit</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Letters read on TWiM 162</p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a>twim@microbe.tv</a></p> <p dir="ltr">This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at <a href= "http://www.cbdstconference.com">http://www.cbdstconference.com</a></p> <p> </p>
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TWiM #161: Eros, a bacterial aphrodisiac
<p dir="ltr">From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank" rel= "noopener">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank" rel="noopener">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank" rel= "noopener">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiM. <a class="jcepopup" title="Two S. rosetta cells touching, a prelude to mating" href= "images/Communications/images/cellspairing_magenta.jpg" target= "_blank" rel="noopener"><img style="margin: 4px; float: right;" src="images/Communications/images/cellspairing_magenta.jpg" alt= "Two S. rosetta cells touching, a prelude to mating" width="250" height="250" /></a></p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Tainted <a href= "https://www.nytimes.com/2017/09/11/health/houston-flood-contamination.html?hp&action=click&pgtype=Homepage&clickSource=story-heading&module=b-lede-package-region&region=top-news&WT.nav=top-news&_r=0"> Houston floodwaters</a> (NYTimes)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Peter Hotez on <a href= "http://www.microbe.tv/twip/29-neglected-tropical-diseases-with-peter-hotez/"> TWiP 29</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "index.php/colloquium-reports/item/4482-faq-microbiology-of-built-environments"> FAQ: Microbiology of Built Environments</a>, American Academy of Microbiology</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://nap.edu/23647">Microbiomes of the Built Environment:  A Research Agenda for Indoor Microbiology, Human Health, and Buildings</a>, The National Academies of Sciences</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28867285">Eukaryotic mating</a> induced by bacterial enzyme (Cell)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Image credit: Arielle Woznica</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Nicole King on <a href= "http://www.microbe.tv/twievo/twievo-11/">TWiEVO 11</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p><a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters/item/6836-twim-161-letters"> Letters read on TWiM 161</a></p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a>twim@microbe.tv</a></p> <p dir="ltr">This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at <a href= "http://www.cbdstconference.com">http://www.cbdstconference.com</a></p>
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TWiM #160: On the road to virus
<p>The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank" rel= "noopener">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank" rel="noopener">Michael Schmidt</a>, and <strong style="font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank" rel="noopener">Michele Swanson</a></strong>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank" rel="noopener">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Regional Zika update, <a href= "http://www.paho.org/hq/index.php?option=com_content&id=11599&Itemid=41691"> Americas</a> (PAHO, WHO)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">FGCU, Zika (<a href= "http://www.microbe.tv/twiv/twiv-454/">TWiV 454</a>)</p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.cdc.gov/zika/reporting/2017-case-counts.html">CDC Graphic of US zika cases as of May 2017</a></p> </li> <li dir="ltr" style= "background-color: #ffffff; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Archaeal plasmid travels cell to cell <a href= "https://www.nature.com/articles/s41564-017-0009-2">via vesicles</a> (Nature Micro)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters">Letters read on TWiM 160</a></p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a>twim@microbe.tv</a></p> <p dir="ltr">This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at <a href= "http://www.cbdstconference.com">http://www.cbdstconference.com</a></p>
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TWiM #159: Immunophage synergy
<p>The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.</p>
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TWiM #158: The bottom line
<p dir="ltr">The TWiM team considers a report on prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Prokaryotic viral sequence <a href= "http://www.pnas.org/content/114/27/7118.abstract">in the brain</a> (PNAS)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Diarrhea <a href= "http://www.sciencedirect.com/science/article/pii/S1931312817302020?via%3Dihub"> clears enteric pathogens</a> (Cell Host Microbe)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://www.jrturnerlab.com">Tight junction biology</a> (Turner Laboratory)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters/item/6753-twim-158-letters"> Letters read on TWiM 158</a></p> </li> </ul> <p> </p> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p> <p> </p>
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TWiM #157: Back to the ancestor
<p>The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank">Vincent Racaniello</a>, <strong style="font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Role of Streptomyces in <a href= "http://www.biorxiv.org/content/early/2017/05/08/131847" target= "_blank">moonmilk</a> (bioRxiv)</p> </li> <li><a href= "http://www.microbe.tv/twim/51-cave-science-with-hazel-barton/" target="_blank">TWiM 51: Cave science with Hazel Barton</a></li> <li> <p dir="ltr"><a href="https://en.wikipedia.org/wiki/Moonmilk" target="_blank">Moonmilk</a> (Wikipedia)</p> </li> <li> <p dir="ltr"><a href= "http://www.sciencedirect.com/science/article/pii/S2211124717305314?via=ihub" target="_blank">Ancient proteins</a> for virus resistance (Cell Rep)</p> </li> <li> <p dir="ltr"><a href= "https://en.wikipedia.org/wiki/Moonmilk#/media/File:Bergmilchkammer_04.jpg" target="_blank">Image credit</a></p> </li> <li><a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters/item/6712-twim-157-letters"> Letters read on TWiM 157</a></li> </ul> <p> Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target= "_blank" rel="noopener noreferrer">twim@microbe.tv</a></p> <p> </p>
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TWiM #156: Gifted microbes and defensive symbiosis
<p dir="ltr">The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Molecular beacons identify <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28119518" target= "_blank">gifted microbes</a> (J Antibiot)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28683136" target="_blank">Defensive symbiosis</a> (PLoS Path)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "index.php/podcasts/twim/twim-letters/item/6676-twim-156-letters" target="_blank">Letters read on TWiM 156</a></p> </li> <li><a href= "https://commons.wikimedia.org/wiki/File:Leptopilina_boulardii.png" target="_blank">Image</a></li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p> <p> </p>
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TWiM #155: Living in the stomach of a cell
<p dir="ltr">Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Legionella in <a href= "http://www.the-scientist.com/?articles.view/articleNo/49613/title/Legionnaires--Disease-Bacteria-Found-in-Flint-Residents--Water/" target="_blank">Flint water</a> (The Scientist)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Q fever with Robert Heinzen (<a href= "http://www.microbe.tv/twim/twim-special-heinzen/" target= "_blank">TWiM Special</a>)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://journal.frontiersin.org/article/10.3389/fcimb.2017.00174/full" target="_blank">Horizontally acquired genes</a> boost C. burnetii (Front Cell Inf Micro)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://en.wikipedia.org/wiki/Coxiella_burnetii#/media/File:Coxiella_burnetii,_the_bacteria_that_causes_Q_Fever.jpg" target="_blank">Image credit</a></p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #154: Rigor, lotteries, and moonshots
<p dir="ltr">At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p><a href="https://www.youtube.com/watch?v=ACwd5-cxnek">Watch the video version</a> recorded live at ASM Microbe 2017!</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28251180">Pathogenic potential</a> of a microbe (mSphere)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/27834205">Rigorous science</a> (mBio)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/27073093">Funding by lottery</a> (mBio)</p> </li> <li><strong style="font-weight: normal;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/27578761">Moonshot science</a> (mBio)</strong></li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #153: Covert pathogenesis
<p dir="ltr">The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from latent reservoirs.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <strong style= "font-weight: normal;"><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a></strong> and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM. <a class="jcepopup" title="exfoliation" href= "images/Communications/images/exfoliation.jpg" target= "_blank"><br style="clear: left;" /></a></p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://www.asm.org/microbe" target= "_blank">ASM Microbe 2017</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://facebook.com/asmfan" target= "_blank">TWiM Live from ASM Microbe 2017</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Landscape of <a href= "http://biorxiv.org/content/early/2017/05/08/134874" target= "_blank">type VI secretion</a> (BioRxiv)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://en.wikipedia.org/wiki/Type_VI_secretion_system#/media/File:Untitled_Diagram.jpg" target="_blank">Type VI secretion</a> structure (jpg)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Activation of dormant E. coli in <a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006238" target="_blank">urinary tract infection</a> (PLoS Path)</p> </li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #152: Wooden steps
<p dir="ltr">The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a><a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank"><br /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM. <a class="jcepopup" title= "Squeezing a giant shipworm out of its calcareous tube. Credit: Marvin Altamia" href="images/Communications/images/wine_beer_water.jpg" target= "_blank"><br style="clear: left;" /></a></p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://asm.org/microbe" target="_blank">ASM Microbe 2017</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://www.pnas.org/content/114/18/E3652" target="_blank">Chemoautotrophic symbiosis</a> in giant shipworm (PNAS)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">There’s gold in them hills (<a href= "http://www.microbe.tv/twim/97-there-s-gold-in-them-hills/" target= "_blank">TWiM 97</a>)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="https://elifesciences.org/content/6/e22054" target="_blank">Vertebrate-algal</a> symbiosis (eLife)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters/item/6447-twim-152-letters"> Letters read on TWiM 152</a></li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #151: Bat and moth antimicrobials
<p dir="ltr">The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths.</p> <p><strong>Hosts: </strong></p> <p><a href="http://virology.ws">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM. <a class="jcepopup" title= "Sign found in the tasting room of a California winery. Photo by Mark Fuccio." href="images/Communications/images/wine_beer_water.jpg" target= "_blank"><br style="clear: left;" /></a></p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">JMBE <a href= "http://www.asmscience.org/about/jmbe-announce-scicomm" target= "_blank">science communication issue</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Bat sources of <a href= "http://aem.asm.org/content/83/5/e03057-16" target="_blank">novel antifungals</a> (AEM)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.whitenosesyndrome.org/sites/default/files/wnsspreadmap_4_24_2017_1.jpg" target="_blank">White nose syndrome</a> in US (jpg)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.whitenosesyndrome.org/sites/default/files/resource/white-nose_fact_sheet_4-2017_0.pdf" target="_blank">White nose syndrome fact sheet (pdf)</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://www.sciencedirect.com/science/article/pii/S245194561630438X" target="_blank">Symbiont-derived antimicrobials</a> (Cell Chem Cell)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="https://en.wikipedia.org/wiki/Bacteriocin" target="_blank">Bacteriocins</a> (Wikipedia)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <a href= "https://www.asm.org/index.php/podcasts/twim/twim-letters/item/6408-twim-151-letters" target="_blank">Letters read on TWiM 151</a></li> </ul> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #150: Microbiology is where it’s at
<p><span style="font-weight: 400;">In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that</span> <em><span style= "font-weight: 400;">Ureaplasma</span></em> <span style= "font-weight: 400;">species can cause a system metabolic disturbance, hyperammonemia.</span></p> <p><span style="font-weight: 400;">Hosts:</span> <a href= "http://www.virology.ws"><span style="font-weight: 400;">Vincent Racaniello</span></a><span style="font-weight: 400;">,</span> <a href="http://schaechter.asmblog.org"><span style= "font-weight: 400;">Elio Schaechter</span></a><span style= "font-weight: 400;">,</span> <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html"> <span style="font-weight: 400;">Michael Schmidt</span></a><span style="font-weight: 400;">, and</span> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm"><span style= "font-weight: 400;">Michele Swanson</span></a></p> <p><span style="font-weight: 400;"><span style= "font-weight: 400;">Guest:</span> <a href= "http://www.mayo.edu/research/faculty/patel-robin-m-d/bio-00026595"> <span style="font-weight: 400;">Robin Patel</span></a></span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><a href= "http://www.ascls.org/medical-laboratory-professionals-week"><span style="font-weight: 400;"> National Laboratory Professionals Week</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Mayo Clinic</span> <a href= "http://www.mayoclinic.org/departments-centers/laboratory-medicine-pathology/overview/specialty-groups/clinical-microbiology"> <span style="font-weight: 400;">Clinical Microbiology Laboratory</span></a></li> <li style="font-weight: 400;"><a href= "http://www.mayo.edu/research/labs/infectious-diseases/overview"><span style="font-weight: 400;"> Infectious Diseases Laboratory</span></a><span style= "font-weight: 400;">, Mayo Clinic</span></li> <li style="font-weight: 400;"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/27796644?dopt=Abstract"><span style="font-weight: 400;"> Murine model</span></a> <span style="font-weight: 400;">of</span> <em><span style="font-weight: 400;">Ureaplasma</span></em> <span style="font-weight: 400;">hyperammonemia (Eur J Clin Microbiol Infect Dis)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Ureaplasma and</span> <a href= "https://www.ncbi.nlm.nih.gov/pubmed/25904745?dopt=Abstract"><span style="font-weight: 400;"> human hyperammonemia</span></a> <span style= "font-weight: 400;">(Sci Transl Med)</span></li> </ul> <p><span style="font-weight: 400;">Become a</span> <a href= "http://www.microbe.tv/contribute"><span style= "font-weight: 400;">patron</span></a> <span style= "font-weight: 400;">of TWiM.</span></p> <p> </p>
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TWiM #149: You’re going to learn R
<p dir="ltr">The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" title= "Injection of microbes into hydraulically fractured shale." href= "images/2016/Podcasts/TWiM/micobe_injection_fractured_shalejpg.jpg" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Special guest: <strong style="font-weight: normal;"><a href= "http://www.schlosslab.org/">Pat Schloss</a></strong></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href="http://www.schlosslab.org/">Schloss Laboratory</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <a href="http://msphere.asm.org/content/2/2/e00073-17" target= "_blank">OptiClust (mSphere)</a></li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to <a href="http://blueapron.com/twim" target="_blank" rel= "noopener noreferrer">blueapron.com/twim</a></p> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a></p>
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TWiM #148: Neanderthal Dentistry
<p>Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes.</p> <p><strong>Hosts:</strong> <a class="jcepopup" title= "lambda virion" href="images/2016/Podcasts/TWiM/lambda_virion.jpg" target="_blank" rel="noopener noreferrer" type="image">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target= "_blank" rel="noopener noreferrer">Elio Schaechter,</a> and <a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank" rel="noopener noreferrer">Michael Schmidt.</a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iPhone" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank" rel="noopener noreferrer">iPhone</a>, <a title= "TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank" rel="noopener noreferrer">Android</a>, <a title= "Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target="_blank" rel= "noopener noreferrer">RSS</a>, or by <a title= "Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank" rel="noopener noreferrer">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">Microbeworld</a> <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank" rel="noopener noreferrer">app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/28273061" target= "_blank" rel="noopener noreferrer">Ancient DNA in Neanderthal teeth</a> (Nature)</li> <li>New <a href="https://www.ncbi.nlm.nih.gov/pubmed/28005056" target="_blank" rel="noopener noreferrer">CRISPRs from metagenomics</a> (Nature)</li> <li><a href="https://en.wikipedia.org/wiki/CRISPR" target="_blank" rel="noopener noreferrer">CRISPR/cas explained</a> (Wikipedia)</li> <li><a href="http://www.asmcue.org" target="_blank" rel= "noopener noreferrer">ASM Conference for Undergraduate Educators</a></li> <li><a href= "https://en.wikipedia.org/wiki/Neanderthals_in_Gibraltar#/media/File:Homo_neanderthalensis_face_(University_of_Zurich).JPG" target="_blank" rel="noopener noreferrer">Image credit</a></li> <li><a href= "http://www.asm.org/index.php/podcasts/twim/twim-letters/item/6271-twim-148-letters" target="_blank">Letters read on TWiM 148</a></li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to <a href="http://blueapron.com/twim" target="_blank" rel= "noopener noreferrer">blueapron.com/twim</a></p> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target="_blank" rel="noopener noreferrer">twim@microbe.tv</a> </p>
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TWiM #147: The Public Goods Dilemma
<p dir="ltr">The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation.</p> <p><strong>Hosts: </strong></p> <p><a title= "Phase separation of red (killers) and blue (non-killers) bacterial populations." href="images/2016/Podcasts/TWiM/ncomms14371-f1.jpg" target= "_blank">Vincent Racaniello</a>, <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a>.</p> <h3>Links for this episode</h3> <ul> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28144629">Phosphate</a> needed for Cryptococcus brain disease (mSphere)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Type VI killing drives <a href= "https://www.ncbi.nlm.nih.gov/pubmed/28165005">phase separation</a> (Nat Rep)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Type VI secretion <a href= "https://www.ncbi.nlm.nih.gov/pubmed/26370934">review</a> (Phil Trans Roy Soc)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr">Microbial <a href= "https://www.eurekalert.org/pub_releases/2017-02/giot-cbs020117.php"> cooperation and conflict</a> (TedX)</p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <p dir="ltr"><a href= "http://www.nature.com/articles/ncomms14371">Image credit</a></p> </li> <li dir="ltr" style= "background-color: transparent; font-weight: 400; vertical-align: baseline;"> <a href= "http://www.asm.org/index.php/podcasts/twim/twim-letters">Letters read on TWiM 147</a></li> </ul> <p><strong style="font-weight: normal;">Become a <a href= "http://www.microbe.tv/contribute">patron</a> of TWiM.</strong></p> <p dir="ltr">This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to <a href= "http://www.blueapron.com/twim">blueapron.com/twim</a></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #146: Viral arbitrium
<p dir="ltr">Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" href="images/2016/Podcasts/TWiM/lysisor.jpg" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank">patron of TWiM</a>.</p> <h3>Links for this episode</h3> <ul> <li>ASM 2017 Election is Open! <a href= "https://secure.intelliscaninc.net/asm/2017/">VOTE HERE</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/28082594">Prions in bacteria</a> (Science)</li> <li><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28099413">Communication</a> guides lysis-lysogeny decisions (Nature)</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to <a href="http://blueapron.com/twim" target="_blank">blueapron.com/twim</a></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM Special: Q fever with Robert Heinzen
<p>Host: <a style= "color: #4da7d4; text-decoration: underline;" href= "http://www.virology.ws">Vincent Racaniello</a></p> <p>Guest: <a href="https://irp.nih.gov/pi/robert-heinzen" target="_blank">Robert Heinzen</a></p> <p><span style="font-weight: 400;">At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, </span><em>Coxiella burneti</em><span style= "font-weight: 400;">.</span></p> <p> </p> <p>Become a <a href="http://www.patreon.com/microbetv" target= "_blank">Patron of TWiM</a>!</p> <h3>Links for this episode</h3> <ul> <li><a href= "https://www.niaid.nih.gov/about/rocky-mountain-laboratories"><span style="font-weight: 400;"> Rocky Mountain Laboratory</span></a></li> <li style="font-weight: 400;"><a href= "https://irp.nih.gov/pi/robert-heinzen"><span style= "font-weight: 400;">Heinzen Laboratory</span></a></li> <li style="font-weight: 400;">Small town, big science (<a href= "http://www.microbe.tv/twim/twim-140">TWiM 140</a>)</li> </ul> <p>Music used on TWiM is composed and performed by <a href= "http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a></p>
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TWiM #145: Anything but academic
<p><span style="font-weight: 400;">Vincent meets up with <span style="font-weight: 400;">Catharine</span> Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower.</span></p> <p><span style="font-weight: 400;">Become a</span> <a href= "http://www.microbe.tv/contribute"><span style= "font-weight: 400;">patron</span></a> <span style= "font-weight: 400;">of TWiM.</span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><a href= "http://www.asm.org/index.php/biothreats-2017"><span style= "font-weight: 400;">ASM Biothreats 2017</span></a></li> <li style="font-weight: 400;"><a href= "https://www.niaid.nih.gov/about/rocky-mountain-laboratories"><span style="font-weight: 400;"> Rocky Mountain Laboratory</span></a></li> <li style="font-weight: 400;"><a href= "https://www.phe.gov/about/BARDA/Pages/default.aspx"><span style= "font-weight: 400;">BARDA</span></a></li> </ul> <p> </p>
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TWiM #144: Did eukaryotes invent anything?
<p dir="ltr">The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" title="cell types" href= "images/2016/Podcasts/TWiM/Celltypes.jpg" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute" target= "_blank">patron of TWiM</a>.</p> <h3>Links for this episode</h3> <ul> <li dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28092141" target= "_blank">Laundry hygiene</a> (J Appl Micro)</li> <li dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pubmed/28082593" target= "_blank">Nucleus-like structure</a> in infected bacteria (Science)</li> <li dir="ltr"><a href="https://www.youtube.com/watch?v=0xM5BhQ2kc8" target="_blank">Video of nucleus assembly in bacteria</a> (YouTube)</li> <li dir="ltr"><a href= "https://upload.wikimedia.org/wikipedia/commons/thumb/8/83/Celltypes.svg/1000px-Celltypes.svg.png" target="_blank">Image credit</a></li> <li dir="ltr">Letters read on TWiM 144</li> </ul> <p>This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to <a href="http://blueapron.com/twim" target="_blank">blueapron.com/twim</a></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #143: E-scaffolds and receptor transfer
<p dir="ltr">Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" title="lambda virion" href= "images/2016/Podcasts/TWiM/lambda_virion.jpg" target="_blank" type= "image">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p><span style="font-size: 12.16px;">Right click to download </span><a style="font-size: 12.16px;" href= "http://traffic.libsyn.com/twimshow/TWiM143.mp3">TWiM#143</a> <span style="font-size: 12.16px;">(32 MB .mp3, 66 minutes).</span></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.microbe.tv/contribute">patron</a> of TWiM.</p> <p><strong>Links for this episode</strong></p> <ul> <li dir="ltr"> <p dir="ltr"><a href= "http://www.nature.com/articles/s41522-016-0003-0">Electrochemical scaffold</a> to eliminate persistent biofilms (npj Biofilms Microbiomes)</p> </li> <li dir="ltr"> <p dir="ltr">Experimental setup for electrochemical treatment of biofilm (<a href= "https://drive.google.com/open?id=0B8dwAT4VdQdjMU1EWXluWDBIOUU">pdf</a>, from <a href= "http://www.nature.com/articles/s41522-016-0003-0">article</a>)</p> </li> <li dir="ltr"> <p dir="ltr">Acquisition of phage sensitivity by transfer of <a href= "http://www.sciencedirect.com/science/article/pii/S0092867416316774"> cell receptors</a> (Cell)</p> </li> <li dir="ltr"> <p dir="ltr"><a href= "http://viralzone.expasy.org/viralzone/all_by_species/142.html">Image credit</a></p> </li> <li dir="ltr"><a href= "http://www.asm.org/index.php/podcasts/twim/twim-letters/item/5452-twim-143-letters"> Letters read on TWiM 143</a></li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code <strong>MICROBE</strong>.</p> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #142: A membrane-thickness caliper
<p dir="ltr">Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" title="caliper" href= "images/2016/Podcasts/TWiM/caliper.jpg" target="_blank" type= "image">Vincent Racaniello</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li dir="ltr"> <p dir="ltr"><a href= "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159414/" target= "_blank">Phenylpyrroles: Nearly no resistance</a> (Front Micro)</p> </li> <li dir="ltr"> <p dir="ltr"><a href= "http://jb.asm.org/content/198/21/2945.abstract">Membrane-thickness caliper</a> (J Bact)</p> </li> <li dir="ltr"><a href= "http://www.asm.org/index.php/podcasts/twim/twim-letters/item/5198-twim-142-letters"> Letters read on TWiM 142</a></li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code <strong>MICROBE</strong>.</p> <p>Send your microbiology questions and comments (email or recorded audio) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #141: Nutritional immunity and polymicrobial infections
<p dir="ltr">Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.</p> <p><strong>Hosts: </strong></p> <p><a class="jcepopup" title="Jennifer Bomberger" href= "images/2016/Podcasts/TWiM/For_TWiM141.jpg" target="_blank" type= "image">Vincent Racaniello</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt.</a></p> <p>Guest: <strong><a href= "http://www.mmg.pitt.edu/person/jennifer-bomberger">Jennifer Bomberger</a></strong></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li dir="ltr"> <p dir="ltr">Virus dysregulation of <strong><a href= "http://www.pnas.org/content/113/6/1642">nutritional immunity</a></strong> (PNAS)</p> </li> <li dir="ltr"> <p dir="ltr"><strong><a href= "http://associationsnow.com/2016/12/podcast-news-get-association-airwaves/"> Podcast article</a></strong> mentioned by Michael</p> </li> <li dir="ltr"> <p dir="ltr"><strong><a href= "http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005797"> Compromised defenses</a></strong> (PLoS Path)</p> </li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code <strong>MICROBE</strong>.</p> <p dir="ltr">This show is sponsored by <a href= "http://www.drobo.com/" target="_blank">Drobo</a>, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM 140: Small town, big science
<p>Host: <a style= "color: #4da7d4; text-decoration: underline;" href= "http://www.virology.ws">Vincent Racaniello</a></p> <p>Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel</p> <p>At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.</p> <p> </p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href= "http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <p>Become a <a href="http://www.patreon.com/microbetv" target= "_blank">Patron of TWiM</a>!</p> <h3>Links for this episode</h3> <ul> <li dir="ltr"><a href= "http://www.microbe.tv/twim/wp-content/uploads/sites/4/2016/11/CxQN-UOUkAA6Itu.jpg-large.jpg" target="_blank">Poster of this event</a> (jpg)</li> <li dir="ltr"><a href= "https://www.niaid.nih.gov/about/rocky-mountain-laboratories" target="_blank">Rocky Mountain Laboratories</a></li> <li dir="ltr"><a href="http://www.hsd3.org/domain/8" target= "_blank">Hamilton, MT high school</a></li> <li>Video of this episode on <a href="https://youtu.be/amZ9bTg39Lg" target="_blank">YouTube</a></li> </ul> <p><span style="font-weight: 400;">This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>Music used on TWiM is composed and performed by <a href= "http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a></p>
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TWiM #139: Frackibacter and sticky fingers
<p dir="ltr">The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth.</p> <p><strong>Hosts: </strong></p> <p><a title= "Injection of microbes into hydraulically fractured shale." href= "images/2016/Podcasts/TWiM/micobe_injection_fractured_shalejpg.jpg" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li dir="ltr">Microbial DNA on ATM machines in NYC (mSphere)</li> <li dir="ltr"><a href="https://nycopendata.socrata.com">NYC OpenData</a></li> <li dir="ltr">Altering <a href= "https://www.ncbi.nlm.nih.gov/pubmed/27595198">deep microbial ecosystems</a> by fracking (Nat Micro)</li> <li dir="ltr"><a href="http://mseel.org">Marcellus Shale Energy and Environment Laboratory</a></li> <li dir="ltr">Chemicals <a href= "https://fracfocus.org/chemical-use/what-chemicals-are-used">used for fracking</a> (FracFocus)</li> <li dir="ltr">Marcellus and Utica <a href= "http://marcelluscoalition.org/pa-map/">shale formation map</a></li> <li dir="ltr"><a href= "https://www.gasbuddy.com/Charts">Consequences</a> of fracking (GasBuddy)</li> <li><strong><a href= "http://www.nature.com/articles/nmicrobiol2016146/figures/4">Image credit</a></strong></li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code <strong>MICROBE</strong>.</p> <p dir="ltr">Register today for the 2017 ASM Scientific Writing and Publishing Online Course at <a href= "http://bit.ly/swpoc17">bit.ly/swpoc17</a></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #138: Learning to love uranium and the A-baum
<p>The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii.</p> <p><strong>Hosts: </strong></p> <p><a href="http://www.virology.ws/about/" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href= "http://kavlichallenge.org/2016/10/24/call-for-submissions-kavli-microbiome-ideas-challenge/" target="_blank">Kavli Microbiome Ideas Challenge</a></li> <li><a href= "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123378" target="_blank">Uranium-respiring bacterium</a> from a field site (PLoS One)</li> <li><a href="https://en.wikipedia.org/wiki/Acid_mine_drainage" target="_blank">Acid mine drainage</a> (Wikipedia)</li> <li><a href="http://aem.asm.org/content/82/20/6174.full.pdf+html" target="_blank">Copper resistance of Acinetobacter baumannii</a></li> <li><a href="http://bit.ly/asmgwoc17" target="_blank">ASM Grant Writing Online Course</a></li> <li><a href= "podcasts/this-week-in-microbiology/archives/2154-twim-132-bacteria-learn-long-division" target="_blank">TWiM #132: Bacteria learn long division</a></li> <li><a href= "https://www.novaerus.com/emea/airborne-transmission/acinetobacter-baumannii/" target="_blank">Image credit</a></li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code <strong>MICROBE​</strong>.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code <strong>Microbe100</strong>.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #137: The battle for oxygen
<p>Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration.</p> <p>Hosts: <a href="http://www.virology.ws/about/" target= "_blank">Vincent Racaniello</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href= "http://schaechter.asmblog.org/schaechter/2016/10/frederick-c-neidhardt-19312016an-obituary.html" target="_blank">Fred Neidhardt obituary</a></li> <li>Recent <a href= "https://sim.confex.com/sim/ramc2016/webprogram/meeting.html" target="_blank">Advances in Microbial Control</a></li> <li>Science hero <a href= "http://myhero.com/hero.asp?hero=fenical_la_times_10_02_06" target= "_blank">Bill Fenical</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27634526" target= "_blank">Virulence factors and aerobic respiration</a> (Science)</li> <li><a href= "https://en.wikipedia.org/wiki/Intestinal_gland#/media/File:Colonic_crypts_within_four_tissue_sections.jpg" target="_blank">Image credit</a></li> <li>Letters read on TWiM 137</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code <strong>MICROBE​</strong>.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code <strong>Microbe100</strong>.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #136: Diderms and then monoderms
<p>Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls.</p> <p>Hosts: <a href="http://www.virology.ws/about/" target= "_blank">Vincent Racaniello</a>, <a href= "http://schaechter.asmblog.org/" target="_blank">Elio Schaechter,</a> <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li>Conquering <a href= "https://www.ncbi.nlm.nih.gov/pubmed/27467389" target= "_blank">neutrophils</a> (PLoS Path)</li> <li>Ancestral <a href= "https://www.ncbi.nlm.nih.gov/pubmed/27580370" target= "_blank">outer membrane in firmicutes</a> (eLife )</li> <li><a href= "http://www.cell.com/trends/microbiology/abstract/S0966-842X(03)00063-5?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0966842X03000635%3Fshowall%3Dtrue" target="_blank">Were gram positive rods the first bacteria?</a> (Cell)</li> <li><a href="https://www.pinterest.com/pin/430023464392068529/" target="_blank">Image credit</a></li> <li>Letters read on TWiM 136</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code <strong>MICROBE​</strong>.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code <strong>Microbe100</strong>.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #135: Unruly individuals and their unruly friends
<h3>Links for this episode</h3> <ul> <li><a href="http://msphere.asm.org/content/1/4/e00199-16" target= "_blank">Dysbiosis of microbiome in critical illness</a> (mSphere)</li> <li>Consequences of <a href= "http://www.ncbi.nlm.nih.gov/pubmed/27422829" target= "_blank">sewage spill into aquatic environment</a> (App Env Mic)</li> <li><a href= "https://www.epa.gov/sites/production/files/2015-10/documents/rec-factsheet-2012.pdf" target="_blank">EPA recreational water guidelines</a> (pdf)</li> <li><a href="https://www.youtube.com/watch?v=9PtZ9bPi0PU" target= "_blank">VRE following sewage spill</a> (Outbreak Radio)</li> <li><a href= "http://academy.asm.org/index.php/faq-series/5122-humanmicrobiome" target="_blank">FAQ: Human microbiome</a></li> <li><a href="http://humanfoodproject.com/americangut/" target= "_blank">American gut project</a></li> <li><a href="https://fundrazr.com/campaigns/4sSf3/ab/5qJ7f" target= "_blank">British gut project</a></li> <li><a href= "https://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are?language=en" target="_blank">Rob Knight on human microbiome</a> (TED)</li> <li><a href= "http://www.microbe.tv/twim/96-a-lean-mean-sequencing-machine/" target="_blank">Rob Knight on TWiM</a></li> <li><a href="http://msphere.asm.org/content/1/4/e00199-16" target= "_blank">Image credit</a></li> <li>TWiM 135 Letters</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code <strong>MICROBE​</strong>.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code <strong>Microbe100</strong>.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #134: Lipids that live forever
<p>Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.</p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target= "_blank">Elio Schaechter,</a> <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/27437587" target= "_blank">Bacterial lysis for in vivo delivery</a> (Nature)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888599/" target="_blank">Coley’s toxins</a> (Iowa Orthop J)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/27527874" target= "_blank">Hopanoids</a>, stress tolerance, and nutrient storage (Geobiol)</li> <li><a href= "http://schaechter.asmblog.org/schaechter/2014/09/bacterial-hopanoids-the-lipids-that-last-forever.html" target="_blank">Lipids that last forever</a> (STC)</li> <li><a href= "http://schaechter.asmblog.org/schaechter/2010/11/fa.html" target= "_blank">Fattening up microbial geological biomarkers</a> (STC)</li> <li><a href="http://www.medscape.com/viewarticle/821787_5" target= "_blank">Money spreads infection</a> (Fut Micro)</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code <strong>MICROBE​</strong>.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code <strong>Microbe100</strong>.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #133: Right under our noses
<p>Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.</p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target= "_blank">Elio Schaechter,</a> and <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href="http://www.pnas.org/content/113/32/8903.long" target= "_blank">Cryo-EM of viruses and vaccine design</a> (PNAS)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/27511920" target= "_blank">Atomic structure of rhinovirus C</a> (PNAS)</li> <li>Opening <a href= "http://schaechter.asmblog.org/schaechter/2016/03/opening-windows-into-the-cell.html" target="_blank">windows into the cell</a> (STC)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/27466123" target= "_blank">Human commensals produce novel antibiotic</a> (Nature)</li> <li><a href= "http://www.nature.com/news/the-nose-knows-how-to-kill-mrsa-1.20339" target="_blank">The nose knows</a> (Nature)</li> <li><a href="component/content/article?id=2162" target= "_blank">Letters read on TWiM 133</a></li> </ul> <p>Image in audio player: Molecular surface of a Human rhinovirus, showing protein spikes. By: Wiki user: Robin S</p> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code MICROBE​.</p> <p>This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href= "http://www.drobo.com" target="_blank">www.drobo.com</a> to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #132: Bacteria learn long division
<p>Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires.</p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a> and <a class="jcepopup" title= "SEM of Y-shaped S. poulsonii." href= "images/stories/TWiM/S_poulsonii.jpg" target="_blank">Elio Schaechter.</a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href="http://mbio.asm.org/content/7/4/e00881-16.full" target="_blank">Cell division by longitudinal scission</a> (mBio)</li> <li><a href= "http://schaechter.asmblog.org/schaechter/2012/11/a-bacterium-learns-long-division.html" target="_blank">Bacterium learns long division</a> (STC)</li> <li>Charge transport by <a href= "http://www.nature.com/articles/srep23517" target= "_blank">microbial nanowires</a> (Sci Rep)</li> <li>Mechanism of <a href= "http://www.nature.com/ncomms/2016/160802/ncomms12217/full/ncomms12217.html" target="_blank">nanowire conductance</a> (Nat Comm)</li> <li><a href= "https://www.ted.com/talks/angela_belcher_using_nature_to_grow_batteries?language=en" target="_blank">Using nature to grow batteries</a> (TED)</li> <li>SEM of Y-shaped <em>S. poulsonii</em> (above) - <a href= "http://mbio.asm.org/content/7/4/e00881-16.full" target= "_blank">Image credit</a></li> <li>Extracellular electron transport (below) - <a href= "http://www.asm.org/index.php/press/147-publications/press/94127-microbe2e-textbook" target="_blank">image credit</a></li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code MICROBE​.</p> <p><span style="font-weight: 400;">This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.</span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM 131: Mice behaving badly
<p>Hosts: <a style= "color: #4da7d4; text-decoration: underline;" href= "http://www.virology.ws">Vincent Racaniello </a>and <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a></p> <p><span style="font-weight: 400;">Michael and Vincent present Spotlights, brief reviews of classic papers in the <em>Journal of Bacteriology</em>, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.</span></p> <p> </p> <h3>Links for this episode</h3> <ul> <li style="font-weight: 400;"><a href= "http://jb.asm.org/content/198/15/2017">Protein secretion</a><span style= "font-weight: 400;"> in </span><em>E. coli</em><span style="font-weight: 400;"> (J Bacteriol)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Plague pathogenesis (J Bacteriol)</span></li> <li style="font-weight: 400;"><span style= "font-weight: 400;">Reversal of </span><a href= "http://www.sciencedirect.com/science/article/pii/S0092867416307309">diet induced social defects</a><span style= "font-weight: 400;"> (Cell)</span></li> <li style="font-weight: 400;"><a href= "http://www.microbe.tv/twim/twim-131-letters/" target= "_blank">Letters read</a> on TWiM 131</li> </ul> <p><span style="font-weight: 400;">This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href= "http://curiositystream.com/microbe" target= "_blank">curiositystream.com/microbe</a> and use the promo code MICROBE.</span></p> <p>Music used on TWiM is composed and performed by <a href= "http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a></p>
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TWiM #130: Interkingdom interactions at ASM Microbe
<p>Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.</p>
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TWiM #129: Dried and wrinkled, smooth and mucoid
<p>The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.</p> <p>Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium.</p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson.</a> </p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href= "http://aac.asm.org/content/early/2016/05/25/AAC.01103-16" target= "_blank">E. coli with mcr-1 on a plasmid in the US</a> (AAC)</li> <li>Emergence of <a href= "http://www.ncbi.nlm.nih.gov/pubmed/26603172" target= "_blank">plasmid mediated colistin resistance in China</a> (The Lancet)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26603171" target= "_blank">Major breach in last line of defense</a> (The Lancet)</li> <li><a href="http://aac.asm.org/content/53/6/2227.full.pdf+html" target="_blank">Resistance plasmid families in Enterobacteriaceae</a> (AAC)</li> <li><a href="http://clincalc.com/eucast/" target="_blank">EUCAST MIC breakpoints</a> (ClinCalc)</li> <li>Role of ASM in microbial resistance <a href= "https://www.asm.org/index.php/ceo-blog/item/63-resisting-resistance-in-microbial-infections-asm-has-a-big-role-to-play-part-1" target="_blank">one</a>, <a href= "https://www.asm.org/index.php/ceo-blog/item/66-resisting-resistance-in-microbial-infections-asm-has-a-big-role-to-play-part-2" target="_blank">two</a> (bLogphase)</li> <li><a href= "http://www.cell.com/cell-host-microbe/fulltext/S1931-3128(16)30162-7?rss=yes" target="_blank">Quorum sensing in fungi</a> (Cell Host Microbe)</li> <li><a href= "https://en.wikipedia.org/wiki/Etest#/media/File:E-test_Ngono.jpg" target="_blank">Image credit</a></li> <li>Letters read on TWiM 129</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code MICROBE​.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #128: A moonlighting phage protein
<p>A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode.</p> <p>Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts.<a class= "jcepopup" title= "An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts. " href="images/stories/TWiM/V-TWiV.JPG" target="_blank"><img style= "margin: 2px; float: right;" src="images/stories/TWiM/V-TWiV.JPG" alt="TWiV agar art" width="300" height="200" /></a></p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target= "_blank">Elio Schaechter,</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>, and <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href= "http://www.the-scientist.com/?articles.view/articleNo/45892/title/Nanoscale-Defenses/" target="_blank">Copper and Michael Schmidt</a> in the news (The Scientist)</li> <li><a href= "http://www.huffingtonpost.com/francis-s-collins-md-phd/fair-pay-for-postdocs-why_b_10011066.html" target="_blank">Fair Pay for Postdocs</a> (Huff Post)</li> <li><a href= "https://www.whitehouse.gov/blog/2016/05/13/announcing-national-microbiome-initiative" target="_blank">National Microbiome Initiative</a> (White House)</li> <li>The <a href= "http://www.the-scientist.com/?articles.view/articleNo/45857/title/The-Shrinking-Mitochondrion/" target="_blank">shrinking mitochondrion</a> (The Scientist)</li> <li><a href= "http://www.cell.com/current-biology/fulltext/S0960-9822(16)30263-9" target="_blank">Eukaryote without a mitochondrion</a> (Curr Biol)</li> <li>Why have <a href= "http://www.sciencedirect.com/science/article/pii/S2405471216300370"> organelles retained genomes?</a> (Cell Sys)</li> <li><a href= "http://academy.asm.org/index.php/genetics-genomics-molecular-microbiology/5297-harnessing-the-power-of-microbes-as-therapeutics-bugs-as-drugs" target="_blank">Bugs as drugs</a> (Amer Acad Micro)</li> <li><a href="https://elifesciences.org/content/5/e13152" target= "_blank">Phage encoded lysin eliminates intracellular bacteria</a> (eLife)</li> </ul> <p>This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at <a href="http://curiositystream.com/m%E2%80%8Bicrobe" target= "_blank">curiositystream.com/m​icrobe</a> ​and use the promo code MICROBE​.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #127: Subway Snowblowers and Men in Black
<p>The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.</p> <p>Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. <span style= "font-weight: 400;">Credit: Canadian Scientific Submersible Facility and the University of Washington</span></p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target= "_blank">Elio Schaechter,</a> <a href= "http://www.med.umich.edu/microbio/bio/swanson_m.htm" target= "_blank">Michele Swanson</a>, and <a href= "http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>.</p> <p><a class="jcepopup" href= "images/stories/TWiM/snowblower_vent800.jpg" target="_blank" type= "image" data-mediabox= "title[Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington]"> <img style="margin: 2px; float: right;" src= "images/stories/TWiM/snowblower_vent800.jpg" alt= "snowblower vent800" width="250" height="166" /></a></p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href= "http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href= "http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href= "http://twimshow.microbeworld.libsynpro.com/" target= "_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href= "http://itunes.apple.com/us/app/id337731458?mt=8" target= "_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href= "http://schaechter.asmblog.org/schaechter/2016/04/elios-day.html" target="_blank">Happy Birthday, Elio</a>!</li> <li><a href= "http://schaechter.asmblog.org/schaechter/2016/04/in-the-company-of-microbes-ten-years-of-small-things-considered-.html" target="_blank">In the Company of Microbes</a></li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/23785361" target= "_blank">Snowblower vents</a> (Front Micro)</li> <li><a href= "http://ooicruises.ocean.washington.edu/visions11/gallery" target= "_blank">Deep-sea snowblower vents</a> video (YouTube)</li> <li><a href= "http://ooicruises.ocean.washington.edu/visions11/gallery" target= "_blank">Visions 11 cruise photos</a></li> <li><a href= "http://www.pnas.org/content/early/2016/04/21/1600546113.short?rss=1" target="_blank">Mycoplasma capture and cleave IgG</a> (PNAS)</li> <li><a href="http://www.nsf.gov/news/mmg/media/images/ooi1_h1.jpg" target="_blank">Snowblower image</a> (large)</li> <li>Letters read on TWiM 127</li> </ul> <p><span style="line-height: 1.4em;">This episode is sponsored by <a href= "backend-submitted-news/2063-call-for-entries-asm-s-2015-agar-art-contest-2?utm_source=twim&utm_medium=podcast&utm_term=agar%20art&utm_campaign=agar%20art%202016" target="_blank">ASM Agar Art Contest</a> and <a href= "http://bit.ly/gwc16" target="_blank">ASM Grant Writing Course</a></span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@microbe.tv" target= "_blank">twim@microbe.tv</a> </p>
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TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)
<p>The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.</p> <p>Hosts: <a href="http://www.virology.ws/" target="_blank">Vincent Racaniello</a>, <a href="http://www.med.umich.edu/microbio/bio/swanson_m.htm" target="_blank">Michele Swanson</a>, and <a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href="http://www.cell.com/cell-reports/abstract/S2211-1247(16)00047-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124716000474%3Fshowall%3Dtrue" target="_blank">Microbiome of hibernating brown bear </a>and energy metabolism (Cell Rep)</li> <li><a href="http://www.conservationinstitute.org/10-animals-that-hibernate/" target="_blank">Ten animals that hibernate</a> (Cons Inst)</li> <li><a href="http://msphere.asm.org/content/1/2/e00062-16.figures-only" target="_blank">Zebrafish model of sepsis (mSphere)</a></li> <li><a href="http://msphere.asm.org/content/1/2/e00062-16.figures-only" target="_blank">Image credit</a></li> <li><a href="component/content/article?id=2104" target="_blank">Letters read on TWiM 126</a></li> </ul> <p><span style="line-height: 1.4em;">This episode is sponsored by <a href="backend-submitted-news/2063-call-for-entries-asm-s-2015-agar-art-contest-2?utm_source=twim&utm_medium=podcast&utm_term=agar%20art&utm_campaign=agar%20art%202016" target="_blank">ASM Agar Art Contest</a> and <a href="http://www.asmmicrobe.org/?&utm_medium=podcast&utm_campaign=asmmicrobe2016" target="_blank">ASM Microbe 2016</a></span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p> </p>
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TWiM #125: A minimal cell operating system
<p>Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.</p> <p>A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li>Culture-independent <a href="http://msphere.asm.org/content/1/2/e00057-16" target="_blank">surveillance of probiotics</a> (mSphere)</li> <li>Design and synthesis of a <a href="http://www.ncbi.nlm.nih.gov/pubmed/27013737" target="_blank">minimal bacterial genome</a> (Science)</li> <li><a href="http://www.jcvi.org/cms/home/" target="_blank">J. Craig Venter Institute</a></li> <li><a href="http://jcvi.org" target="_blank">Image credit</a></li> <li>Letters read on TWiM 125</li> </ul> <p><span style="line-height: 1.4em;">This episode is sponsored by <a href="backend-submitted-news/2063-call-for-entries-asm-s-2015-agar-art-contest-2?utm_source=twim&utm_medium=podcast&utm_term=agar%20art&utm_campaign=agar%20art%202016" target="_blank">ASM Agar Art Contest</a> and <a href="http://www.asmmicrobe.org/?&utm_medium=podcast&utm_campaign=asmmicrobe2016" target="_blank">ASM Microbe 2016</a></span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p> </p> <p><span style="font-weight: 400;"> </span></p>
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TWiM #124: Fungal pirates
<p>Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.</p> <p>Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li>Michele on <a href="http://www.detroitnews.com/story/news/michigan/flint-water-crisis/2016/03/01/legionella-flint-water/81187168/" target="_blank">Flint Legionella outbreak </a>(Detroit News)</li> <li><a href="http://www.cell.com/cell-host-microbe/abstract/S1931-3128(16)30016-6?rss=yes" target="_blank">Fungal mimicry</a> of a mammalian aminopeptidase (Cell Host Micr)</li> </ul> <p> </p> <p><span style="line-height: 1.4em;">This episode is sponsored by <a href="http://bit.ly/agarart2" target="_blank">ASM Agar Art Contest</a> and <a href="http://www.asmmicrobe.org/?&utm_medium=podcast&utm_campaign=asmmicrobe2016" target="_blank">ASM Microbe 2016</a></span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #123: A microbial MAGE
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws" target="_blank">Vincent Racaniello</a>, <a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p>Guest: <a href="http://wanglab.c2b2.columbia.edu" target="_blank">Harris Wang</a></p> <p>Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/19633652" target="_blank">MAGE - Multiplex automated genome engineering</a> (Nature)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/22484848" target="_blank">Genome-scale promoter engineering</a> (Nat Methods)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26916078" target="_blank">Manipulating microbial communities in situ</a> (Trends Genet)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/24838875" target="_blank">Engineering human microbiomes</a> (Meth Mol Biol)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/23340847" target="_blank">Genome-scale engineering</a> (Mol Syst Biol)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26222307" target="_blank">Economic framework of microbial trade</a> (PLoS One)</li> <li><a href="http://bit.ly/tardigradet" target="_blank">Tardigrade t-shirt</a></li> <li><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132907" target="_blank">Image credit</a></li> </ul> <p>This episode is sponsored by <span style="line-height: 1.4em;"><a href="http://microbeworld.org/mmp" target="_blank">Microbe Magazine Podcast</a> and <a href="http://www.asmmicrobe.org/?&utm_medium=podcast&utm_campaign=asmmicrobe2016" target="_blank">ASM Microbe 2016</a></span></p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p> <p class="_mce_tagged_br"> </p>
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TWiM #122: Mayonii, microRNAs and the microbiome
<p>Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <p>Identification of a novel <a href="http://www.ncbi.nlm.nih.gov/pubmed/26856777" target="_blank">Borrelia species causing Lyme disease</a> (Lancet Inf Dis)</p> <p><a href="http://www.microbe.tv/twip/75-parasite-wonders-with-bobbi-pritt/" target="_blank">Parasite wonders with Bobbi Pritt</a> (TWiP 75)</p> <p><a href="http://www.cdc.gov/lyme/stats/maps/interactiveMaps.html" target="_blank">Reported cases of Lyme disease</a> (CDC)</p> <p><a href="http://www.cdc.gov/lyme/signs_symptoms/index.html" target="_blank">Signs and symptoms of Lyme disease</a> (CDC)</p> <p><a href="http://www.mlst.net" target="_blank">Multilocus sequence typing</a></p> <p><a href="http://pubmlst.org/borrelia/" target="_blank">Borrelia MLST database</a></p> <p>American Academy of Microbiology <a href="http://academy.asm.org/index.php/faq-series/5122-humanmicrobiome" target="_blank">FAQ Human microbiome</a></p> <p>Host <a href="http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00497-7?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312815004977%3Fshowall%3Dtrue" target="_blank">fecal microRNA shapes gut microbiota</a> (Cell)</p> <p><a href="http://www.public-domain-image.com/free-images/science/microscopy-images/borrelia-burgdorferi/grouping-of-gram-negative-anaerobic-borrelia-burgdorferi-bacteria" target="_blank">Image credit</a></p> <p><a href="http://bit.ly/curegame" target="_blank">C.U.R.E. the game</a></p> <p><a href="http://bit.ly/tardigradeT" target="_blank">Live Tiny, Die Never - Tardigrade T-shirt</a></p> <p><span style="line-height: 1.4em;">This episode is sponsored by <a href="http://microbeworld.org/mmp" target="_blank">Microbe Magazine Podcast</a> and <a href="http://www.asmmicrobe.org/?&utm_medium=podcast&utm_campaign=asmmicrobe2016" target="_blank">ASM Microbe 2016</a></span></p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p> </p>
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TWiM #121: A plague of pathogens
<p>Host: Vincent Racaniello</p> <p>Special guests: <a href="https://www.linkedin.com/in/rebekah-kading-63453556" target="_blank">Rebekah Kading</a> and <a href="http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=18254" target="_blank">Wyndham Lathem</a></p> <p>From the<a href="http://www.asmbiodefense.org/" target="_blank"> ASM Biodefense and Emerging Diseases Research</a> meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague.</p> <center></center> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26038446" target="_blank">Rift Valley fever virus risk</a> (Emerg Micr Inf)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/25211133" target="_blank">Predicting Rift Valley fever virus transmission</a> (PLoS NTD)</li> <li><a href="http://www.bioone.org/doi/full/10.2987/8756-971X-28.4.100" target="_blank">Culex in New York City</a> (BioOne)</li> <li>Early <a href="http://www.ncbi.nlm.nih.gov/pubmed/26123398" target="_blank">emergence of Y. pestis</a> (Nature Comm)</li> <li><a href="http://www.cell.com/trends/microbiology/abstract/S0966-842X(15)00273-5?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0966842X15002735%3Fshowall%3Dtrue" target="_blank">Pneumonic plague</a> (Trends Micro)</li> </ul> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #120: Snakes in trouble
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws" target="_blank">Vincent Racaniello</a> and <a href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p>Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/24407482" target="_blank">Tubeworm metamorphosis by phage tail-like structures</a> (Science)</li> <li>Cell enzyme becomes <a href="http://www.virology.ws/2015/12/09/exaptation-a-cell-enzyme-becomes-a-viral-capsid-protein/" target="_blank">viral capsid protein</a> (virology blog)</li> <li><a href="http://mbio.asm.org/content/6/6/e01534-15" target="_blank">Snake fungal disease in the laboratory</a> (mBioi)</li> <li><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140193" target="_blank">Snake fungal disease in cottonmouths</a> (PLoS Biol)</li> <li><a href="http://www.northeastparc.org/products/pdfs/NEPARC_SnakeFungalDiseaseFAQ.pdf" target="_blank">Snake fungal disease</a> (pdf)</li> <li><a href="http://mbio.asm.org/content/6/6/e01534-15" target="_blank">Image credit</a></li> </ul> <p>This episode is sponsored by<a href="http://www.asmgap.org/index.php/grant-writing-institute-online" target="_blank"> ASM Grant Writing Institute Online Webinar</a> and <a href="http://www.asm.org/cvs2016" target="_blank">32nd Clinical Virology Symposium</a></p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p> <p class="_mce_tagged_br"> </p>
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TWiM #119: Power of one
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p>The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li>Revised estimates of <a href="http://biorxiv.org/content/early/2016/01/06/036103" target="_blank">human and bacterial cells</a> in the body (biorxiv)</li> <li><a href="http://schaechter.asmblog.org/schaechter/2010/07/power-of-ten.html" target="_blank">Power of ten</a> (Small Things Considered)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26721997" target="_blank">Solar-to-chemical production in bacteria</a> (Science)</li> <li><a href="http://www.microbeworld.org/component/content/article?id=2054">Letters read on TWiM 119</a></li> </ul> <p>This episode is sponsored by<a href="http://www.asmgap.org/index.php/grant-writing-institute-online" target="_blank"> ASM Grant Writing Institute Online Webinar</a> and <a href="http://www.asm.org/cvs2016" target="_blank">32nd Clinical Virology Symposium</a></p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p> <p class="_mce_tagged_br">Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by <a href="https://commons.wikimedia.org/wiki/User:Ali_Zifan">Ali Zifan</a> - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.</p> <p class="_mce_tagged_br"> </p>
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TWiM #118: Spore-drops keep fallin’ on my head
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a></p> <p>On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26079718" target="_blank">Pack hunting by a common soil amoeba on nematodes</a> (Environ Micro)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/26509436" target="_blank">Mushrooms as rainmakers</a> (PLoS One)</li> <li><a href="http://astore.amazon.com/virologyws-20/detail/0199732566" target="_blank">Mushroom by Nicholas Money</a></li> <li><a href="http://astore.amazon.com/virologyws-20/detail/0674445546" target="_blank">In the Company of Mushrooms</a> by Elio Schaechter</li> <li><a href="https://en.wikipedia.org/wiki/Nitrogen_fixation" target="_blank">Image credit</a></li> <li>Letters read on TWiM 118</li> </ul> <p>This episode is sponsored by <a href="http://www.asmmicrobe.org/" target="_blank">ASM Microbe 2016</a> and <a href="http://www.asmbiodefense.org/" target="_blank">ASM Biodefense</a></p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p>
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TWiM #117: Finding the comammox
<p><span style="font-weight: 400;">The TWiM team marvels over the finding of a completely nitrifying </span><em><span style="font-weight: 400;">Nitrospira</span></em><span style="font-weight: 400;">, and horizontal gene transfer from </span><em><span style="font-weight: 400;">Wolbachia</span></em><span style="font-weight: 400;"> into an animal genome.</span></p> <p><span style="font-weight: 400;">Links for this episode:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Complete nitrification by </span><em><span style="font-weight: 400;">Nitrospira</span></em><span style="font-weight: 400;"> bacteria (Nature </span><a href="http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature16461.html"><span style="font-weight: 400;">one</span></a><span style="font-weight: 400;">, </span><a href="http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature16459.html"><span style="font-weight: 400;">two</span></a><span style="font-weight: 400;">)</span></li> <li style="font-weight: 400;"><a href="http://phys.org/news/2015-11-microbiologists-enigmatic-comammox-microbes.html"><span style="font-weight: 400;">Enigmatic</span></a><span style="font-weight: 400;"> comammox (PhysOrg)</span></li> <li style="font-weight: 400;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/11544365"><span style="font-weight: 400;">Ammonia-oxidizing</span></a><span style="font-weight: 400;"> bacteria (Ann Rev Micro)</span></li> <li style="font-weight: 400;"><a href="http://www.sciencealert.com/new-research-casts-doubt-on-the-claim-that-tardigrades-get-one-sixth-of-dna-from-other-species"><span style="font-weight: 400;">Tardigrade</span></a><span style="font-weight: 400;"> controversy (SciAlert)</span></li> <li style="font-weight: 400;"><a href="https://peerj.com/articles/1479/"><span style="font-weight: 400;">Horizontal gene transfer</span></a><span style="font-weight: 400;"> from </span><em><span style="font-weight: 400;">Wolbachia</span></em><span style="font-weight: 400;"> to grasshopper (PeerJ)</span></li> <li style="font-weight: 400;"><a href="https://en.wikipedia.org/wiki/Nitrogen_fixation"><span style="font-weight: 400;">Thumbnail Image (nitrogen cycle) credit</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Letters read on TWiM 117</span></li> </ul> <p><br /><span style="font-weight: 400;">This episode is sponsored by </span><a href="http://www.asm.org/microbe2016"><span style="font-weight: 400;">ASM Microbe 2016</span></a><span style="font-weight: 400;"> and </span><a href="http://www.asm.org/biodefense2016"><span style="font-weight: 400;">ASM Biodefense</span><span style="font-weight: 400;"><br /></span></a></p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p>
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TWiM #116: Chewates and coconuts
<p>Hosts: <a href="http://www.virology.ws">Vincent Racaniello</a>, <a style="border: 0px; outline: 0px; font-size: 12px; vertical-align: baseline; background-color: transparent; padding: 0px; margin: 0px;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a></p> <p>The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by <em>Candida albicans</em>.</p> <h3>Links for this episode </h3> <ul> <li>Bee <a href="http://www.sciencedirect.com/science/article/pii/S0960982215011082" target="_blank">cultivates fungus</a> to survive (Curr Biol)</li> <li><a href="http://dx.doi.org/10.1128/mSphere.00020-15" target="_blank">Diet reduces</a> <em>C. albicans</em> gut colonization (mSphere)</li> <li><a href="http://msphere.asm.org/" target="_blank">mSphere</a>, a new open-access ASM journal</li> <li><a href="https://www.flickr.com/photos/phuthinhco/7651679180" target="_blank">Image credit</a></li> <li><a href="podcasts/this-week-in-microbiology/letters/2034-twim-116-letters" target="_blank">Letters read</a> on TWiM 116</li> </ul> <p>This episode is sponsored by <a href="http://www.asm.org/biodefense2016" target="_blank">ASM Biodefense</a> and the <a href="http://www.asm.org/cvs2016" target="_blank">32nd Clinical Virology Symposium</a>.</p> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>.</p>
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TWiM #115: Profiling the Poglianos
<p>Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells.</p> <p>Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!</p>
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TWiM #114: Milestones in Blue
<p><span style="font-weight: 400;">Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the laboratory has advanced the science and teaching of microbiology, and discuss faculty work on uropathogenic E. coli, induction of stress by bacterial infection, and the gut microbiome. </span></p> <p><span style="font-weight: 400;">Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> for more including the special video version of this episode. </span></p>
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TWiM #113: Waves of Change
<p><span style="font-weight: 400;">Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation sequencing and advanced molecular diagnostics.</span></p> <p><span style="font-weight: 400;">Visit microbeworld.org/twim to watch the video version and for complete shownotes including links mentioned. </span></p>
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TWiM #112: Mushroom pickers and mushroom kickers
<p>The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus.</p> <p>Image: Lesion formation on banana surfaces infected with Aspergillus terreus. <a href="http://elifesciences.org/content/4/e07861/article-data##">Source</a></p> <p>Links mentioned:</p> <p> </p> <ul> <li><a href="http://www.asm.org/index.php/fellowships-2/25-education/students/142-asm-undergraduate-research-capstone-program-ur-capstone-2015" target="_blank">ASM Undergraduate Research Capstone Program</a></li> <li><a href="http://www.asm.org/index.php/fellowships-2/25-education/students/7827-asm-undergraduate-research-fellowship-asm-urf?utm_source=asmbulkemail&utm_medium=email&utm_campaign=urf16" target="_blank">ASM Undergraduate Fellowship Program</a></li> <li>Regulation of <a href="http://elifesciences.org/content/4/e07861" target="_blank">terrein production in Aspergillus terreus</a></li> </ul> <p>Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> for more.</p> <p> </p>
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TWiM #111: Ancientbiotics and modernbiotics
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, and <a style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; border-width: 0px; padding: 0px; margin: 0px;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter.</a></p> <p>The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron.</p> <p>Subscribe to TWiM (free) on <a title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode </h3> <ul> <li><a href="http://mbio.asm.org/content/6/4/e01129-15.full" target="_blank">1,000 year old antimicrobial</a> (mBio)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935367/" target="_blank">Siderophore quenching</a> with gallium (Evol Med Pub Health)</li> <li><a href="http://onlinelibrary.wiley.com/doi/10.1111/jeb.12559/abstract" target="_blank">Evolutionary dynamics of public goods</a> (J Evol Biol)</li> <li><a href="http://mbio.asm.org/content/6/4/e01129-15.full?sid=5278ce18-5e94-4d6e-8c35-d72c9aa3b198" target="_blank">Image credit</a></li> <li>Letters read on TWiM 111</li> </ul> <p>Music used on TWiM is composed and performed by <a href="http://ronaldjenkees.com" target="_blank">Ronald Jenkees</a> and used with permission.</p> <p class="_mce_tagged_br">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #110: Exploring unseen life with unpronounceable words
<p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a style="color: rgb(77, 167, 212);" title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a style="color: rgb(77, 167, 212);" title="TWiM on Android" href="http://subscribeonandroid.com/twimshow.microbeworld.libsynpro.com/" target="_blank">Android</a>, <a style="color: rgb(77, 167, 212);" title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a style="color: rgb(77, 167, 212);" title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode </h3> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="backend-submitted-news/1901-call-for-entries-asm-s-2015-agar-art-contest" target="_blank">Agar art contest</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://gut.bmj.com/content/early/2015/05/22/gutjnl-2014-308778.full.pdf+html" target="_blank">Akkermansia muciniphilia and obesity</a> (Gut)</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25888298" target="_blank">A. muciniphilia genome</a> (Biol Direct)</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://mbio.asm.org/content/6/4/e00974-15" target="_blank">Alterations of gut microbiota</a> and C. difficile colonization (mBio)</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://www.science-delivered.org" target="_blank">Science Delivered</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://girlswhocode.com" target="_blank">Girls Who Code</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://femmes.studentorgs.umich.edu" target="_blank">F.E.M.M.E.S.</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://www.awis.org" target="_blank">Association for Women in Science</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="http://medicine.umich.edu/medschool/research/research-strengths/host-microbiome-initiative" target="_blank">UMich Host-Microbiome Initiative</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"><a style="color: rgb(77, 167, 212);" href="https://drive.google.com/file/d/0B8dwAT4VdQdjV2puSG5lVHctcGc/view" target="_blank">UMich anaerobic chamber room</a> (png)</p>
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TWiM #109: Precision killing
<p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium </span><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:italic;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Wolbachia</span><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> selectively kills male hosts. </span></p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"> </p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-left: 5pt;margin-right: 5pt;text-indent: -4pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Links for this episode:</span></p> <ul style="margin-top:0pt;margin-bottom:0pt;"> <li dir="ltr" style="list-style-type:disc;font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Antimicrobial peptides to </span><a style="text-decoration:none;" href="http://www.pnas.org/content/112/24/7569.abstract"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">modulate microbial ecology</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (PNAS)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13.333333333333332px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><a style="text-decoration:none;" href="http://www.sciencedirect.com/science/article/pii/S0966842X15001535"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">Targeting specific bacteria</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> in the oral microbiome (Trends Micro)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13.333333333333332px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">How </span><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:italic;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Wolbachia</span><a style="text-decoration:none;" href="http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005048"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">kills male hosts</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (PLoS Biol)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13.333333333333332px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:italic;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Wolbachia</span><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> phage on </span><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;"><a style="text-decoration:none;" href="http://www.twiv.tv/2015/04/12/twiv-332/">TWiV 332</a></span></p> </li> </ul> <p> </p> <p>Image: Transmission electron micrograph of Wolbachia within an insect cell.</p> <p>By: Scott O'Neill - Genome Sequence of the Intracellular Bacterium Wolbachia. PLoS Biol 2/3/2004: e76.</p>
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TWiM #108: Vaccine in the time of cholera
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; padding: 0px; margin: 0px; border: 0px initial initial;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span> </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The professors of TWiM discuss a University of Wisconsin plan for rescuing biomedical research in the US, and results of a clinical trial in Bangladesh of an oral cholera vaccine.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: #4da7d4;" title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a style="color: #4da7d4;" title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a style="color: #4da7d4;" title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a style="color: #4da7d4;" title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a style="color: #4da7d4;" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55;">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li class="_mce_tagged_br" style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://elifesciences.org/content/4/e09305" target="_blank">Rescuing biomedical research</a> (eLife)</li> <li class="_mce_tagged_br" style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://www.ibiology.org/ibiomagazine/issue-11/keith-yamamoto-time-to-rethink-graduate-and-postdoc-education.html" target="_blank">Rethinking graduate and postdoc education</a> (iBiology)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://www.ncbi.nlm.nih.gov/pubmed/26164097" target="_blank">Oral cholera vaccine trial</a> (Lancet) </li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://www.nytimes.com/2015/07/09/health/promise-is-seen-in-an-inexpensive-cholera-vaccine.html?_r=0" target="_blank">Inexpensive cholera vaccine</a> (NYTimes)</li> <li class="_mce_tagged_br" style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://www.ivi.org/event_news/news/popup_shanchol.html" target="_blank">Image credit</a></li> <li class="_mce_tagged_br" style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 3.78125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/component/content/article?id=1947">Letters read on TWiM 108</a></li> </ul>
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TWiM #107: The battle in your bladder
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: rgb(77, 167, 212);" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.65625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://advances.sciencemag.org/content/1/3/e1500183" target="_blank">Microbiome of uncontacted Amerindians</a> (Sci Adv)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.65625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Urinary composition controls <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25861985" target="_blank">siderocalin activity</a> (J Biol Chem)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.65625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Urine acidity and <a style="color: rgb(77, 167, 212);" href="http://www.infectioncontroltoday.com/news/2015/06/a-persons-diet-urine-acidity-may-affect-susceptibility-to-utis.aspx" target="_blank">UTI susceptibility</a> (Infect Cont Today)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.65625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=3CMP" target="_blank">Image (from pdb file 3cmp)</a> shows siderocalin (magenta) complexed</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.65625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">with iron (orange) and enterobactin (sticks)</li> </ul> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: rgb(77, 167, 212);" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #106: Lawn mower disease
<p> </p> <p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against </span><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Franciscella tularensis</span><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">, the causative agent of tularemia.</span></p>
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TWiM #105: Real bugs with legs
<p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis.</span></p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"> </p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-left: 5pt;margin-right: 5pt;text-indent: -4pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Links for this episode:</span></p> <p> </p> <ul style="margin-top:0pt;margin-bottom:0pt;"> <li dir="ltr" style="list-style-type:disc;font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Microbes in </span><a style="text-decoration:none;" href="http://onlinelibrary.wiley.com/doi/10.1111/jam.12855/abstract;jsessionid=C9C5F519345975066F803535BF219FE2.f01t02"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">whole-leaf herbs</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (J Appl Micro)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Antimicrobial peptide </span><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/25984971"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">blocks ribosome</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (Nat Struct Mol Biol)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Bacterial </span><a style="text-decoration:none;" href="http://mmbr.asm.org/content/69/1/101"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">protein synthesis</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (Micro Mol Biol Rev)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/11807545"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">Antimicrobial</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> peptides (Nature)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">The battle for </span><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/?term=24616884"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">tryptophan</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (Front Cell Infect Micro)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"><a style="text-decoration:none;" href="http://commons.wikimedia.org/wiki/File:Oncopeltusfasciatus.jpg"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">Image credit</span></a></li> </ul>
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TWiM #104: Feed me polyamines, biofilm
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; padding: 0px; margin: 0px; border: 0px initial initial;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span> </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: #4da7d4;" title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a style="color: #4da7d4;" title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a style="color: #4da7d4;" title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a style="color: #4da7d4;" title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a style="color: #4da7d4;" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55;">Links for this episode</h3> <p>Measles vaccination prevents <a style="color: #4da7d4;" href="http://www.ncbi.nlm.nih.gov/pubmed/25954009" target="_blank">all-cause infectious disease</a> (Science)</p> <p><a style="color: #4da7d4;" href="http://phenomena.nationalgeographic.com/2015/02/05/how-the-measles-virus-became-a-master-of-contagion/" target="_blank">Master of contagion</a> (The Loom)</p> <p>Video: <a style="color: #4da7d4;" href="http://www.sciencemag.org/content/suppl/2015/05/06/348.6235.694.DC1/aaa3662_s1.mp4" target="_blank">Measles incidence to immunomodulation</a> (Science)</p> <p><a style="color: #4da7d4;" href="http://academy.asm.org/index.php/faq-series/433-adultvaccinesfaq" target="_blank">FAQ: Adult vaccines</a></p> <p>Metabolism links <a style="color: #4da7d4;" href="http://www.ncbi.nlm.nih.gov/pubmed/25959674" target="_blank">biofilms and colon cancer</a> (Cell Metab)</p> <p><a style="color: #4da7d4;" href="https://xcmsonline.scripps.edu" target="_blank">Scripps Center for Metabolomics</a></p> <p>Scripps <a style="color: #4da7d4;" href="https://metlin.scripps.edu/index.php" target="_blank">metabolite database</a></p> <p><a style="color: #4da7d4;" href="http://en.wikipedia.org/wiki/Spermine" target="_blank">Image credit</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Sponsors for this episode: <a style="color: #4da7d4;" href="http://www.scimedsolutions.com" target="_blank">SciMedSolutions</a>, <a style="color: #4da7d4;" href="http://www.icaac.org" target="_blank">ICAAC-ICC</a></p> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: #4da7d4;" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiM #103: The battle for iron
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; border-width: 0px; padding: 0px; margin: 0px;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiM team is amazed by the ocelloid, and an evolutionary battle for iron between mammalian transferrin and bacterial transferrin-binding protein.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" title="TWiM on iTunes" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846&ls=1https://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846?mt=2&ls=1" target="_blank">iTunes</a>, <a style="color: rgb(77, 167, 212);" title="TWiM on Stitcher" href="http://www.stitcher.com/podcast/this-week-in-microbiology-with-vincent-racaniello" target="_blank">Stitcher</a>, <a style="color: rgb(77, 167, 212);" title="Subscribe to TWiM" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS</a>, or by <a style="color: rgb(77, 167, 212);" title="Subscribe to TWiM via email" href="http://eepurl.com/Hu-U9" target="_blank">email.</a> You can also listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">A unicellular <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25734540" target="_blank">camera-type eye structure</a> (PLoS One)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Escape from <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25504720" target="_blank">iron piracy</a> (Science)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/23684303" target="_blank">Iron in infection and immunity</a> (Cell Host Micr)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.nature.com/nrmicro/journal/v10/n8/full/nrmicro2836.html" target="_blank">Nutritional immunity</a> (Nat Rev Micro)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://evolutionarypath.org" target="_blank">Evolutionary Path</a> (Matthew Barber)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Image credit: <a style="color: rgb(77, 167, 212);" href="http://onemicron.com" target="_blank">Janet Iwasa</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 8.3125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Sponsors for this episode: <a style="color: rgb(77, 167, 212);" href="http://www.scimedsolutions.com" target="_blank">SciMedSolutions</a>, <a style="color: rgb(77, 167, 212);" href="http://www.icaac.org" target="_blank">ICAAC-ICC</a> <ul style="line-height: 15.399999618530273px;"> <ul style="line-height: 15.399999618530273px;"></ul> </ul> </li> </ul> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: rgb(77, 167, 212);" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiM #102: Happiness is the spore-formers in your gut
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; padding: 0px; margin: 0px; border: 0px initial initial;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiM team discusses evidence that serotonin synthesis is regulated by spore-forming members of the gut microbiota.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: #4da7d4;" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: #4da7d4;" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: #4da7d4;" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: #4da7d4;" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55;">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">When <a style="color: #4da7d4;" href="http://schaechter.asmblog.org/schaechter/2015/03/when-antibiotic-resistance-in-vitro-does-not-tell-you-what-you-need-to-know.html" target="_blank">antibiotic resistance in vitro</a> falls short (STC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Gut microbiota control <a style="color: #4da7d4;" href="http://www.sciencedirect.com/science/article/pii/S0092867415002482" target="_blank">serotonin in mice</a> (Cell)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://en.wikipedia.org/wiki/Serotonin#/media/File:Serotonin_biosynthesis.svg" target="_blank">Serotonin biosynthesis</a> (Wikipedia)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://schaechter.asmblog.org/schaechter/2012/08/the-road-to-microbial-endocrinology.html" target="_blank">Microbial endocrinology</a> (STC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://en.wikipedia.org/wiki/Serotonin#/media/File:Serotonin_biosynthesis.svg" target="_blank">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 6.328125px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Sponsors for this episode: <a style="color: #4da7d4;" href="http://www.scimedsolutions.com" target="_blank">SciMedSolutions</a>, <a style="color: #4da7d4;" href="http://jmbe.asm.org/index.php/jmbe" target="_blank">Jmbe.asm.org</a>, <a style="color: #4da7d4;" href="http://www.icaac.org" target="_blank">ICAAC-ICC</a></li> </ul> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: #4da7d4;" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Image: Serotonin temporary tattoo by <a href="https://www.flickr.com/photos/chezshawna/396442691">flickr user: ChezShawna</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiM #101: The MRSA in your home
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; border-width: 0px; padding: 0px; margin: 0px;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiMers discuss how aroma helps disperse yeast cells on insect vectors, and evidence that MRSA is transmitted within households.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: rgb(77, 167, 212);" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.15625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Aroma promotes <a style="color: rgb(77, 167, 212);" href="http://www.cell.com/cell-reports/abstract/S2211-1247(14)00777-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124714007773%3Fshowall%3Dtrue" target="_blank">yeast dispersal on flies</a> (Cell Rep)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.15625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25759497" target="_blank" rel="nofollow">MRSA is transmitted within households</a> (mBio)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.15625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">FAQ: The <a style="color: rgb(77, 167, 212);" href="http://academy.asm.org/index.php/faq-series/5292-faqmrsa" target="_blank" rel="nofollow">threat of MRSA</a> (AAM)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.15625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.cell.com/cell-reports/abstract/S2211-1247(14)00777-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124714007773%3Fshowall%3Dtrue" target="_blank" rel="nofollow">Image credit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.15625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"> <ul style="line-height: 15.399999618530273px;"> <ul style="line-height: 15.399999618530273px;">Letters read</ul> </ul> <span style="line-height: 1.4em;"> on TWiM 101</span></li> </ul> <p class="_mce_tagged_br" style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: rgb(77, 167, 212);" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiM #100: Omnis cellula e cellula
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; padding: 0px; margin: 0px; border: 0px initial initial;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4;" href="https://www.whitehouse.gov/administration/eop/ostp/about/leadershipstaff/handelsman" target="_blank">Jo Handelsman</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span> </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: #4da7d4;" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: #4da7d4;" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: #4da7d4;" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: #4da7d4;" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: #384b55;">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4.21875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">A single <a style="color: #4da7d4;" href="http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3219.html" target="_blank">mutation alters bacterial tropism</a> (Nat Gen)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4.21875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://schaechter.asmblog.org/schaechter/2013/12/talmudic-question-104.html" target="_blank">Talmudic question #104</a> (Small Things Considered)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4.21875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://www.asmscience.org/content/book/10.1128/9781555818517" target="_blank">Principles of Microbial Diversity</a> (ASM Press)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4.21875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: #4da7d4;" href="http://jmbe.asm.org/index.php/jmbe" target="_blank">Journal of Microbiology & Biology Education</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); line-height: 1.4em; height: 4.21875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="http://www.microbeworld.org/component/content/article?id=1868">Letters read</a> on TWiM 100</li> </ul> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: #4da7d4;" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: #4da7d4;" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Image: Yellow colonies of S. aureus on a blood agar plate, note regions of clearing around colonies caused by lysis of red cells in the agar By: HansN. on wikimedia. From the study (Nat Gen) "...only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits." </p>
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TWiM #99: Careers in Biodefense
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="text-decoration: none;" href="http://www.virology.ws">Vincent Racaniello</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Guests: <a style="text-decoration: none;" href="https://www.linkedin.com/pub/maria-julia-marinissen-ph-d/6/649/975">Maria Julia Marinissen</a>, <a style="text-decoration: none;" href="https://www.linkedin.com/profile/view?id=70666802&authType=NAME_SEARCH&authToken=hh_0&locale=en_US&srchid=120557241424887216424&srchindex=1&srchtotal=10327&trk=vsrp_people_res_name&trkInfo=VSRPsearchId%3A120557241424887216424%2CVSRPtargetId%3A70666802%2CVSRPcmpt%3Aprimary">Edward H. You</a>, and David R. Howell</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent meets up with Maria, Edward, and David at the ASM Biodefense and Emerging Infections Research meeting to talk about alternative careers for scientists.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: rgb(77, 167, 212);" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">A video version of this episode is available at <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> </h3> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode:</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.90625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" title="ASM Biodefense" href="http://www.asmbiodefense.org/" target="_blank">ASM Biodefense meeting</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.90625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" title="FBI Biological Countermeasures Unit" href="http://www.fbi.gov/news/stories/2012/february/wmd_022112/wmd_022112" target="_blank">FBI Biological Countermeasures Unit</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.90625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" title="Office of Policy and Planning" href="http://www.phe.gov/about/OPP/Pages/default.aspx" target="_blank">Office of Policy and Planning</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.90625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" title="Division of Medical Countermeasures Strategy and Requirements" href="http://www.phe.gov/about/OPP/mcsr/Pages/default.aspx" target="_blank">Division of Medical Countermeasures Strategy and Requirements</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 3.90625px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" title="Division of International Health Security" href="http://www.phe.gov/about/OPP/dihs/Pages/default.aspx" target="_blank">Division of International Health Security</a></li> </ul> <p style="margin: 0.2em 0px 1em; padding: 0px;"><br /><span style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16.8000011444092px;">Send your microbiology questions and comments (email or mp3 file) to </span><a style="margin: 0px; padding: 0px; border: 0px; outline: 0px; font-size: 12px; vertical-align: baseline; font-family: Helvetica, Arial, FreeSans, sans-serif; line-height: 16.8000011444092px; background-image: initial; background-attachment: initial; background-position: initial; background-repeat: initial;" href="mailto:twim@twiv.tv">twim@twiv.tv</a><span style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16.8000011444092px;">, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at </span><a style="margin: 0px; padding: 0px; border: 0px; outline: 0px; font-size: 12px; vertical-align: baseline; font-family: Helvetica, Arial, FreeSans, sans-serif; line-height: 16.8000011444092px; background-image: initial; background-attachment: initial; background-position: initial; background-repeat: initial;" href="http://microbeworld.org/" target="_blank">microbeworld.org</a><span style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16.8000011444092px;"> and tag them with twim.</span></p>
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TWiM #98: Bacteria and eukaryotes get horizontal
<p> </p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">The TWiM crew ponders the question of how a bacterium finds its middle when dividing, then divulge the transfer of interbacterial antagonism genes to eukaryotes, where they may function in innate defense.</span></p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"> </p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-left: 5pt;margin-right: 5pt;text-indent: -4pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Links for this episode:</span></p> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"> </p> <ul style="margin-top:0pt;margin-bottom:0pt;"> <li dir="ltr" style="list-style-type:disc;font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Size independent </span><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/25221974"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">symmetric division</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (Nat Commun)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">How does a bacterium </span><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/11062548"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">find its middle</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">? (Nat Struct Biol)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Genes transferred from bacteria augment </span><a style="text-decoration:none;" href="http://www.ncbi.nlm.nih.gov/pubmed/25470067"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">eukaryotic defenses</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (Cell)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:13px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"> <p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt;margin-right: 5pt;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Antibacterial </span><a style="text-decoration:none;" href="http://elifesciences.org/content/3/e04266"><span style="font-size:16px;font-family:Arial;color:#1155cc;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap;">gene transfer</span></a><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"> (eLife)</span></p> </li> <li dir="ltr" style="list-style-type:disc;font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;"><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;"><a href="http://www.microbeworld.org/component/content/article?id=1849">Letters read on TWiM #98</a> on TWiM 98</span></li> </ul> <p><span style="font-size:16px;font-family:Arial;color:#000000;background-color:transparent;font-weight:normal;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap;">Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> for complete shownotes and more.</span></p>
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TWiM #97: There’s gold in them hills
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">The TWiM team reveal how bacteria in a shipworm’s gills help digest wood in the gut, and an approach that identifies a new antibiotic from the soil.</span></p> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"> </p> <p dir="ltr" style="line-height: 1.15; text-indent: -4pt; margin: 0pt 5pt 0pt 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Links for this episode:</span></p> <p> </p> <ul style="margin-top: 0pt; margin-bottom: 0pt;"> <li dir="ltr" style="list-style-type: disc; font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://www.pnas.org/content/111/47/E5096.abstract"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Gill bacteria</span></a><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> enable a novel digestive strategy (PNAS)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 13px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Killing bacteria </span><a style="text-decoration: none;" href="http://www.nature.com/nature/journal/v517/n7535/full/nature14098.html"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">without resistance</span></a><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> (Nature)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 13px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">An </span><a style="text-decoration: none;" href="http://www.nature.com/nature/journal/v517/n7535/full/nature14193.html"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">irresistable</span></a><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> newcomer (Nature)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 13px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://www.microbelibrary.org/images/spencer/spencer_cellwall.html"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Peptidoglycan synthesis</span></a><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> animation</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 13px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">10 x 20 </span><a style="text-decoration: none;" href="http://www.idsociety.org/10x20/"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">initiative</span></a><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> (IDSA)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 13px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"><a style="text-decoration: none;" href="https://longitudeprize.org/"><span style="font-size: 16px; font-family: Arial; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Longitude Prize</span></a></li> </ul> <p><span style="font-size: 12pt;">Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> for more.</span></p>
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TWiM #96: A lean, mean sequencing machine
<p>Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>.</p> <p>Special guest: <a href="https://knightlab.colorado.edu" target="_blank">Rob Knight</a></p> <p>Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants.</p> <p>Check out the <a href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3>Links for this episode</h3> <ul> <li><a href="http://www.nature.com/news/microbes-en-masse-the-sequencing-machine-1.10985" target="_blank">Microbes en masse</a> (Nature)</li> <li>Obesity alters <a href="http://www.pnas.org/content/102/31/11070.abstract" target="_blank">gut microbial ecology</a> (PNAS)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/23599893" target="_blank">Sharing microbiome with dogs</a> (eLife)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/25184604" target="_blank">Earth microbiome</a> project (BMC Biology)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/23828941" target="_blank">Stability of gut micobiota</a> (Science)</li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/25392516" target="_blank">Gut microbes and the brain</a> (J Neurosci)</li> </ul> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #95: A microbe lover in San Diego
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: rgb(77, 167, 212);" href="http://www.virology.ws">Vincent Racaniello</a>.<a style="color: rgb(77, 167, 212);" href="http://schaechter.asmblog.org/" target="_blank"><br /></a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Special guest: <a style="color: rgb(77, 167, 212);" href="http://www.bio.sdsu.edu/faculty/maloy.html" target="_blank">Stanley Maloy</a></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.</p> <div>Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: rgb(77, 167, 212);" href="http://feeds.feedburner.com/twim" target="_blank">RSS feed</a>, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</div> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode: </h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.046875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.sci.sdsu.edu/~smaloy/Research/maloy_lab.htm" target="_blank">Maloy lab</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.046875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://www.salmonella.org" target="_blank">Salmonella.org</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.046875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Microbial genetics <a style="color: rgb(77, 167, 212);" href="http://www.sci.sdsu.edu/~smaloy/MicrobialGenetics/" target="_blank">course page</a></li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 4.046875px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://en.wikipedia.org/wiki/Typhoid_Mary" target="_blank">Typhoid Mary</a></li> </ul> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: rgb(77, 167, 212);" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p> <p style="margin: 0.2em 0px 1em; padding: 0px;"> </p>
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TWiM #94: Nitrochondria
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.</span></p> <p dir="ltr" style="line-height: 1.15; text-indent: -4pt; margin: 0pt 5pt 0pt 5pt;"> </p> <p dir="ltr" style="line-height: 1.15; text-indent: -4pt; margin: 0pt 5pt 0pt 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Links for this episode:</span></p> <p dir="ltr" style="line-height: 1.15; text-indent: -4pt; margin: 0pt 5pt 0pt 5pt;"> </p> <ul style="margin-top: 0pt; margin-bottom: 0pt;"> <li dir="ltr" style="list-style-type: disc; font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Unicellular cyanobacterium and alga </span><a style="text-decoration: none;" href="http://www.ncbi.nlm.nih.gov/pubmed/22997339"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">symbiosis</span></a><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> (Science)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://www.ncbi.nlm.nih.gov/pubmed/24761991"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Diversity</span></a><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> of nitrogen-fixing cyanobacterium and its host (Environ Micro)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://schaechter.asmblog.org/schaechter/2006/12/talmudic_quesit.html"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Talmudic Question #4</span></a><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> (</span><a style="text-decoration: none;" href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002020"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">answer</span></a><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">)</span></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://schaechter.asmblog.org/schaechter/2006/12/another_talmudi.html"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Talmudic Question #2</span></a></p> </li> <li dir="ltr" style="list-style-type: disc; font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><a style="text-decoration: none;" href="http://en.wikipedia.org/wiki/Coccolithophore"><span style="font-size: 19px; font-family: Calibri; color: #1155cc; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: underline; vertical-align: baseline; white-space: pre-wrap;">Coccolithophore</span></a><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> (Wikipedia)</span></p> </li> </ul> <p><span style="font-size: 19px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> to view the complete shownotes and entire back catalog. </span></p>
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TWiM #93: Worming in on bacteria
<p> </p> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio, and Michael reveal that a soil-dwelling nematode can recognize and respond to a bacterial quorum sensing molecule through a sensory neuron.</span></p>
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TWiM #92: Flying biofilms
<p style="margin: 0px; font-size: 12px; font-family: Arial;">Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.</p> <p> </p>
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TWiM #91: Rats, viruses, and bacteria
<p>Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City.</p> <p>Visit <a href="http://microbeworld.org/twim">microbeworld.org/twim</a> for complete show notes. Thanks for listening!</p>
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TWiM #90: Think globally, act locally
<p> </p> <p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent meets up with Laurene and David at the Annual Meeting of the Southern California Branch of the American Society for Microbiology, where they discuss how the Los Angeles County Department of Health is preparing for an outbreak of Ebola virus infection, and Cepheid’s game-changing, modular PCR system for the diagnosis of infectious diseases.</span></p>
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TWiM #89: Microbial handoffs
<p>Vincent, Michele, and Michael discuss how a gene from bacteria protects a tick from plant cyanide poisoning, and enhanced transmission of Streptococcus pneumoniae by influenza virus co-infection in mice.</p>
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TWiM #88: A century of excellence in microbiology
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Michele speaks with members of the Department of Bacteriology at the University of Wisconsin - Madison, on the occasion of its designation as a Milestones in Microbiology site, where they discuss how the department has advanced the science and teaching of microbiology.</span></p> <div><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> </span></div>
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TWiM #87: Avogadro, archaeal fossils, and ICAAC
<p style="padding: 0px; margin: 0.2em 0px 1em 0px;">Vincent, Elio, and Michael explore the fossilization of archaeal lipids, and highlight the recent ICAAC in Washington, D.C.</p> <div> </div>
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TWiM #86: Blurring the line between organelle and endosymbiont
<p style="margin: 0.2em 0px 1em; padding: 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; border-width: 0px; padding: 0px; margin: 0px;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.<span class="Apple-style-span" style="font-family: Arial; font-size: 12px;"><span class="Apple-style-span"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></span></span></p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Vincent, Elio, Michael, and Michele consider whether our eating behavior is manipulated by gastrointestinal microbiota, and an aphid gene of bacterial origin whose gene product encodes a protein that is transported to an obligate endosymbiont. </p> <p style="margin: 0.2em 0px 1em; padding: 0px;">Subscribe to TWiM (free) on <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: rgb(77, 167, 212);" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: rgb(77, 167, 212);" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: rgb(77, 167, 212);" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; margin: 1em 0px 0.2em; padding: 0px; color: rgb(56, 75, 85);">Links for this episode</h3> <ul style="margin: 0.2em 0px 1em; padding: 0px; list-style: none;"> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-127.html" target="_blank">National Biosafety Stewardship</a> month</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Aphid gene of <a style="color: rgb(77, 167, 212);" href="http://www.cell.com/current-biology/abstract/S0960-9822(14)00754-4" target="_blank">bacterial origin</a> (Curr Biol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Eroding <a style="color: rgb(77, 167, 212);" href="http://www.cell.com/current-biology/abstract/S0960-9822(14)00674-5" target="_blank">symbiont/organelle distinction</a> (Curr Biol)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Is our eating <a style="color: rgb(77, 167, 212);" href="http://www.ncbi.nlm.nih.gov/pubmed/25103109" target="_blank">manipulated by our microbiota?</a> (Bioessays)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Road to <a style="color: rgb(77, 167, 212);" href="http://schaechter.asmblog.org/schaechter/2012/08/the-road-to-microbial-endocrinology.html" target="_blank">microbial endocrinology</a> (STC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Microbial <a style="color: rgb(77, 167, 212);" href="http://schaechter.asmblog.org/schaechter/2007/08/microbial-endoc.html" target="_blank">endocrinology</a> (STC)</li> <li style="padding: 0.4em 0px 0.4em 36px; background-image: url(http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif); line-height: 1.4em; height: 7px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a style="color: rgb(77, 167, 212);" href="component/content/article?id=1744" target="_blank">Letters read</a> on TWiM 86</li> </ul> <p style="margin: 0.2em 0px 1em; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: rgb(77, 167, 212);" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: rgb(77, 167, 212);" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #85: Oscillation in the ocean and a Verona integron
<p>Vincent, Elio, Michael, and Michele discuss the diel transcriptional rythmns of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.</p>
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TWiM #84: Microbiology Down Under
<p>In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.</p>
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TWiM #83: Illuminating tuberculosis and cryptococcosis
<p style="font: normal normal normal 12px/normal Arial; margin: 0px;"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;">Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system. </span></p> <div><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></div>
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TWiM #82: Betrayal and compromise
<p style="padding: 0px; margin: 0.2em 0px 1em 0px;">Hosts: <a style="color: #4da7d4; text-decoration: underline;" href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, <a style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; padding: 0px; margin: 0px; border: 0px initial initial;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a> and <a style="color: #4da7d4; text-decoration: underline;" href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>.</p> <p style="outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; font: normal normal normal 12px/normal Arial; background-position: initial initial; background-repeat: initial initial; padding: 0px; margin: 0px; border: 0px initial initial;">Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of neonates.</p> <p style="font: normal normal normal 12px/normal Arial; margin: 0px;"><span class="Apple-style-span" style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> </span></p> <p style="padding: 0px; margin: 0.2em 0px 1em 0px;">Subscribe to TWiM (free) on <a style="color: #4da7d4; text-decoration: underline;" href="http://itunes.apple.com/us/podcast/this-week-in-microbiology/id422332846" target="_blank">iTunes</a>, via <a style="color: #4da7d4; text-decoration: underline;" href="http://twimshow.microbeworld.libsynpro.com/" target="_blank">RSS feed</a>, by <a style="color: #4da7d4; text-decoration: underline;" href="http://eepurl.com/Gcw59" target="_blank">email</a> or listen on your mobile device with the <a style="color: #4da7d4; text-decoration: underline;" href="http://itunes.apple.com/us/app/id337731458?mt=8" target="_blank">Microbeworld app</a>.</p> <h3 style="font-size: 1.2em; color: #384b55; font-weight: bold; padding: 0px; margin: 1em 0px 0.2em 0px;">Links for this episode</h3> <ul style="list-style-type: none; list-style-position: initial; list-style-image: initial; padding: 0px; margin: 0.2em 0px 1em 0px;"> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;">Endosymbiont protein <a style="color: #4da7d4; text-decoration: underline;" href="http://www.pnas.org/content/111/24/8919.abstract" target="_blank">betrays aphid</a> (PNAS)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;"><a style="color: #4da7d4; text-decoration: underline;" href="http://www.nature.com/nature/journal/v444/n7117/full/nature05286.html" target="_blank">Plant immune system</a> (Nature)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;"><a style="color: #4da7d4; text-decoration: underline;" href="https://www.apsnet.org/edcenter/intropp/topics/Pages/OverviewOfPlantDiseases.aspx" target="_blank">Plant defenses</a> against pathogens (Am Phyt Soc)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;">New neonatal <a style="color: #4da7d4; text-decoration: underline;" href="http://www.nature.com/nature/journal/v504/n7478/full/nature12675.html" target="_blank">defense against infection</a> (Nature)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;"><a style="color: #4da7d4; text-decoration: underline;" href="https://www.youtube.com/watch?v=OaPOXvw28_M&feature=youtu.be" target="_blank">Marty Blaser and Bill Maher</a> (YouTube)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;"><a style="color: #4da7d4; text-decoration: underline;" href="https://www.youtube.com/watch?v=X-rEUFbHQ5M&feature=youtu.be" target="_blank">Two days from any village</a> (YouTube)</li> <li style="background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 3px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; padding: 0.4em 0px 0.4em 36px;">Letters read on TWiM 82</li> </ul> <p style="padding: 0px; margin: 0.2em 0px 1em 0px;">Send your microbiology questions and comments (email or mp3 file) to <a style="color: #4da7d4; text-decoration: underline;" href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a style="color: #4da7d4; text-decoration: underline;" href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #81: Cold iron is the master of them all
<p><span class="Apple-style-span" style="font-family: Arial; font-size: 12px;">Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling <em>Salmonella</em> by modulating host iron homeostasis. </span></p>
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TWiM #80: Hurling fleas and designer chromosomes
<p>Hosts: <a href="http://www.virology.ws">Vincent Racaniello</a>, <a style="color: #4da7d4; text-decoration: underline;" href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a>, and <a href="http://www.med.umich.edu/microbio/bio/swanson_m.htm">Michele Swanson</a>. </p> <p>Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas.</p> <h3>Links for this episode:</h3> <ul> <li style="font: normal normal normal 12px/normal Arial; margin-top: 0px; margin-right: 0px; margin-bottom: 0px;"><a href="http://www.sciencemag.org/content/344/6179/55.long" target="_blank"><span style="color: #1a70d3;">Total synthesis</span></a> of a yeast chromosome (Science)</li> <li style="font: normal normal normal 12px/normal Arial; margin-top: 0px; margin-right: 0px; margin-bottom: 0px;">Evolution of <em>Y. pestis</em> to <a href="http://www.sciencedirect.com/science/article/pii/S1931312814001371" target="_blank"><span style="color: #1a70d3;">flea-borne transmission</span></a> (Cell Host Micr)</li> <li style="font: normal normal normal 12px/normal Arial; color: #1a70d3; margin-top: 0px; margin-right: 0px; margin-bottom: 0px;"><a href="http://en.wikipedia.org/wiki/Proventriculus" target="_blank"><span style="font: normal normal normal 10px/normal Verdana; color: #000000;"><span style="font: normal normal normal 12px/normal Arial;">Proventricular valve</span></span></a><span style="color: #000000;"> (Wikipedia)</span></li> <li style="font: normal normal normal 12px/normal Arial; margin-top: 0px; margin-right: 0px; margin-bottom: 0px;"><a href="http://www.publicdomainfiles.com/show_file.php?id=13521829816137" target="_blank"><span style="font: normal normal normal 10px/normal Verdana;"><span style="font: normal normal normal 12px/normal Arial; color: #1a70d3;">Image</span></span></a>: flea with <em>Y. pestis</em> proventricular mass</li> <li style="font: normal normal normal 12px/normal Arial; margin-top: 0px; margin-right: 0px; margin-bottom: 0px;">Letters read on TWiM 80</li> </ul> <p>Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank">microbeworld.org</a> and tag them with twim.</p>
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TWiM #79: A community of microbiologists
<p>Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.</p>
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TWiM #78: A bacterium grows in Brooklyn
<p>Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn. </p>
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TWiM #77: Zombie plants and no pain, no gain
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Arial;">Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of <span style="color: #2d2d2d;">sensory neurons that modulate pain and inflammation by bacterial infection.</span></p> <div><span style="color: #2d2d2d;"> </span></div>
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TWiM #76: Genetic biopixels and a pathogenic sweet tooth
<p>Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.</p> <div> </div>
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TWiM #75: Pellicles on pickle jars
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.</span></p> <div><span style="font-size: 16px; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> </span></div>
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TWiM #74: It came from the Siberian permafrost
<p>Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.</p>
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TWiM #73: Eyeing root nodule development
<div style="background-color: #ffffff; color: #000000; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px;"> <p>Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS. </p> </div>
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TWiM #72: The benefits of virulence
<p>Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.</p> <div> </div>
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TWiM #71: Colon cancer’s little shop of horrors
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px;">Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.</p> <div></div>
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TWiM #70: A paroxysmal cough
<p><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px;">Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological profiling to identify pathways targeted by antibiotics.</span></p>
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TWiM #69: Bacterial DNA in the human genome
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div>
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TWiM #68: The fungus among us
<p><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px;">Vincent, Elio, Michael, and Michele discuss the amazingly high level of intergenera gene exchange among haloarchaea in an Antarctic lake, and the diversity of fungi on residential surfaces and the human forehead. <a href="http://www.microbeworld.org/images/stories/TWiM/tested_surfaces.png" class="jcepopup" target="_blank" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; line-height: 0; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;"></a></span></p>
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TWiM #67: Black mushrooms and RNA thermosensors
<p><span class="Apple-style-span" style="font-size: 11px;">Vincent, Elio, and Michael discuss how temperature triggers Neisseria menigitidis immune evasion, and protection of mice from ionizing radiation by feeding them black mushrooms.<a href="images/stories/TWiM/auricularia_auricula-judae.png" class="jcepopup" data-mediabox="title[auricularia_auricula-judae. Original image by: Josh Milburn at mushroomobserver.org]" target="_blank" style="color: #4da7d4; text-decoration: underline;"></a></span></p>
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TWiM #66: The shape of a container
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent, Elio, Michael, and Michele discuss the curious outer membrane vesicles of Neisseria meningitides, and sources of Clostridium difficile infection revealed by genome sequencing.</p> <div></div> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;"><a href="images/stories/TWiM/outer_membrane_vesicles.png" class="jcepopup" data-mediabox="title[Outer Membrane vesicles ]" target="_blank" style="color: #4da7d4; text-decoration: underline;"></a></p>
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TWiM #65: Leanness is transmissible
<p><span class="Apple-style-span" style="font-size: 11px;"></span></p> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Hosts: <a href="http://www.virology.ws" style="color: #4da7d4; text-decoration: underline;">Vincent Racaniello</a> and <a href="http://www.med.umich.edu/microbio/bio/swanson_m.htm" target="_blank" style="color: #4da7d4; text-decoration: underline;">Michelle Swanson</a>.</p> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice.</p> <h3 style="font-size: 1.2em; margin-top: 1em; margin-right: 0px; margin-bottom: 0.2em; margin-left: 0px; color: #384b55; font-weight: bold; padding: 0px;">Links for this episode:<span style="color: #000000; font-size: 11px;"> </span></h3> <ul style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; list-style-type: none; list-style-position: initial; list-style-image: initial; padding: 0px;"> <li style="padding-top: 0.4em; padding-right: 0px; padding-bottom: 0.4em; padding-left: 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;">Gut microbiota <a href="http://www.sciencemag.org/content/341/6150/1241214.accessible-long" target="_blank" style="color: #4da7d4; text-decoration: underline;">modulate metabolism</a> (Science) </li> <li style="padding-top: 0.4em; padding-right: 0px; padding-bottom: 0.4em; padding-left: 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;"><a href="http://www.sciencemag.org/content/341/6150/1069.summary" target="_blank" style="color: #4da7d4; text-decoration: underline;">Fighting obesity</a> with bacteria (Science)</p> </li> <li style="padding-top: 0.4em; padding-right: 0px; padding-bottom: 0.4em; padding-left: 36px; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 5px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat;"><a href="component/content/article?id=1482" target="_blank" style="color: #4da7d4; text-decoration: underline;">Letters read</a> on TWiM 065</li> </ul> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" target="_blank" style="color: #4da7d4; text-decoration: underline;">twim@twiv.tv</a>, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at <a href="http://microbeworld.org" target="_blank" style="color: #4da7d4; text-decoration: underline;">microbeworld.org</a> and tag them with twim.</p> <p></p>
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TWiM #64: URI and UTI at ICAAC in Denver
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Verdana; background-color: transparent; font-weight: normal; vertical-align: baseline; white-space: pre-wrap;">Vincent and Michael recorded this episode at the 53rd ICAAC in Denver, where they spoke with James Gern and James Johnson about rhinoviruses and extra-intestinal pathogenic </span><span style="font-size: 16px; font-family: Verdana; background-color: transparent; font-weight: normal; font-style: italic; vertical-align: baseline; white-space: pre-wrap;">E. coli</span><span style="font-size: 16px; font-family: Verdana; background-color: transparent; font-weight: normal; vertical-align: baseline; white-space: pre-wrap;">.</span></p> <div><span style="font-size: 16px; font-family: Verdana; background-color: transparent; font-weight: normal; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div>
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TWiM #63: Superantigens, S. aureus, and the armpit microbiome
<p><span style="font-size: 11px; text-align: left;">Vincent, Michael, and Michelle discuss how a Staphylococcus aureus superantigen is critical for pathogenesis in a rabbit model, and the relationship of body odor to the axilla microbiome.</span><a href="images/stories/TWiM/grapes.png" class="jcepopup" target="_blank" style="color: #4da7d4; font-size: 11px; text-align: left;"></a></p>
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TWiM #62: Breaking bad and protein chain mail
<p>Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid </p> <div></div>
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TWiM #61: The irony of probiotics
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.</p> <div></div>
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TWiM #60: Microbial electrochemistry and diversity-generating retroelements
<p>Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.</p> <div></div>
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TWiM #59: Are viruses part of our immune system?
<p>Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.</p>
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TWiM #58: The brain microbiome?
<p dir="ltr" style="line-height: 1.15; margin-top: 0pt; margin-bottom: 0pt; margin-right: 5pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div>
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TWiM #57: Updating the human gut microbiome to degrade seaweed
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates. </p> <div></div>
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TWiM #56: Live at ASM in Denver
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria.</p> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">This episode was filmed live at ASM GM 2013 in Denver, CO. Visit www.microbeworld.org/asmlive to watch the full video archive of this episode as well as all the videos recorded during GM. </p> <div></div>
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TWiM #55: In the copper room
<p><span class="Apple-style-span" style="font-size: 11px;">Vincent, Elio and Michael discuss the finding that copper surfaces reduce microbial burden and hospital-acquired infections in the intensive care unit.<a class="jcepopup" href="images/stories/TWiM/CopperRoom.jpg" rel="title[Copper hospital room]" target="_blank" style="color: #4da7d4; text-decoration: underline;"></a></span></p>
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TWiM #54: Dueling injectors and the microgenderome
<p>Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.</p>
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TWiM #53: Live in Manchester
<p><span class="Apple-style-span" style="font-size: 11px;">Vincent, Laura, David, Kalin and Paul get together at the Society for General Microbiology meeting in Manchester, England to talk about next-generation approaches to antimicrobial therapy.<a class="jcepopup" type="image" href="images/stories/TWiM/TWiMinManchester.JPG" rel="title[TWiM in Manchester, England]" target="_blank" style="color: #4da7d4; text-decoration: underline;"></a></span></p>
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TWiM #52: Clinical microbiology with Ellen Jo Baron
<div style="background-color: transparent; font-family: Times; font-size: medium;"><b id="internal-source-marker_0.22035245061852038" style="font-weight: normal;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent and Michael meet up with Ellen Jo Baron to talk about working in a clinical microbiology laboratory.</span></b></div>
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TWiM #51: Cave science with Hazel Barton
<p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; padding: 0px;">Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.</p> <div></div>
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TWiM #50: These things aren’t even bacteria!
<p style="margin: 0.2em 0px 1em; padding: 0px; color: #000000; font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;">Vincent, Michael, and Stanley review the scientific career of Carl Woese.</p> <div></div>
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TWiM #49: Grape-like Clusters
<div style="background-color: transparent; font-family: Times; font-size: medium;"> <p dir="ltr" style="margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Elio discuss the HIV co-receptor CCR5 as a receptor for </span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">S. aureus</span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> leukotoxin ED, and the vineyard yeast microbiome.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div> </div>
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TWiM #48: It’s all about direction
<div style="background-color: transparent; font-family: Times; font-size: medium;"> <p dir="ltr" style="margin-right: 5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Jo discuss how subtle gender bias of science faculty favors male students, and the relationship of invasive infection and antibody orientation at bacterial surfaces.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div> </div>
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TWiM #47: Resistance on the surface
<p>Horizontal transfer of antibiotic resistance genes on metal surfaces, and using bacteriophage to reverse antibiotic resistance.</p>
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TWiM #46: Spore!
<div style="font-family: Times; font-size: medium;"> <div> <p dir="ltr">Vincent, Michael, and Elio meet up with Jonathan Dworkin to discuss how bacteria form spores and how they return to vegetative growth.</p> <div></div> </div> </div>
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TWiM #45: Secreted nucleic acids RIG a STING
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">Vincent, Michael, Elio review i</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.36076273466460407">nnate immune sensing of Listeria secreted bacterial nucleic acids, and how Wolbachia enhances egg production in Drosophila.<a href="images/stories/TWiM/mask.jpg" mce_href="images/stories/TWiM/mask.jpg" title="Plague doctor mask" target="_blank" class="jcebox"></a></span></span></p>
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TWiM #44: Phage interruptus
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">Vincent, Michael, Elio </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.36076273466460407">discuss the role of prophage excision in exit of Listeria from the phagosome, and analysis of bacterial communities in saliva.<a class="jcebox" target="_blank" title="Listeria lifecycle " href="images/stories/TWiM/listeria_lifecycle.png" mce_href="images/stories/TWiM/listeria_lifecycle.png"></a></span></span></p>
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TWiM #43: Bacterial caveolae and zapping acne with phages
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">Vincent, Michael, Elio </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.5536990966647863">review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.<a href="images/stories/TWiM/caveolae.jpg" mce_href="images/stories/TWiM/caveolae.jpg" title="Caveolae" target="_blank" class="jcebox"></a></span></span></p>
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TWiM #42: Staphylococcus, a three-star pathogen
<p>Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.</p>
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TWiM #41: ICAAC live in San Francisco
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; background-color: transparent; vertical-align: baseline; white-space: pre-wrap;">Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.</span></p> <div><span style="font-size: 16px; font-family: Verdana; background-color: transparent; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div>
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TWiM #40: A mecca for microbiology
<div style="background-color: transparent; font-family: Times; font-size: medium;"> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!**</span></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent and Stanley meet with Waclaw Szybalski and John Kirby at Cold Spring Harbor Laboratory on the occasion of its designation as a Milestones in Microbiology site. They reminisce about how the well known laboratory has advanced the science and teaching of microbiology, and discuss John’s work on the soil dwelling, predatory myxobacteria.</span></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">If you don't have the app, please visit www.microbeworld.org/app to get more information about downloading the app for your iOS or Android device. </span></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">This video is also available for free at www.microbeworld.org in the TWiM section, epsiode #40.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div> </div>
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TWiM #39: What Darwin never knew
<div style="background-color: transparent; font-family: Times; font-size: medium;"> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Elio reviews chapters from </span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Microbes and Evolution</span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">, a collection of short, personal essays by microbiologists.</span></p> <div><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><br /></span></div> </div>
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TWiM #38: The sound of whooping cough
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.</span></p>
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TWiM #37: Microbial Jekyll and Hyde
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.</span></p>
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TWiM #36: Domesticating a pathogen
<p dir="ltr" style="font-family: Times; font-size: medium;">Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.</p> <div></div>
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TWiM #35: Ohne hauch
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; background-color: transparent; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.</span></p>
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TWiM #34: Doing the DISCO with Emiliania
<p style="font-family: Times; font-size: medium;">Hosts: <a target="_blank" href="http://www.virology.ws/" mce_href="http://www.virology.ws/">Vincent Racaniello</a>, <span id="internal-source-marker_0.24935460928827524"><a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" mce_href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a>, </span><span id="internal-source-marker_0.22292107669636607">and <a href="http://schaechter.asmblog.org/" mce_href="http://schaechter.asmblog.org/" target="_blank">Elio Schaechter</a></span></p> <p style="font-family: Times; font-size: medium;">Vincent, Michael, and Elio discuss changing populations of <i>Emiliania huxleyi</i> and their viruses in the North and Black Seas.</p> <p style="font-family: Times; font-size: medium;">Right click to download <a target="_blank" href="http://traffic.libsyn.com/twimshow/TWiM034.mp3" mce_href="http://traffic.libsyn.com/twimshow/TWiM034.mp3">TWiM #34</a> (50 MB .mp3, 69 minutes).</p> <h3 style="font-family: Times;">Links for this episode:</h3> <ul style="font-family: Times; font-size: medium;"> <li>The <a href="http://www.microbemagazine.org/index.php/12-2011-animalcuules-and-forum/4150-the-protist-wonderland" mce_href="http://www.microbemagazine.org/index.php/12-2011-animalcuules-and-forum/4150-the-protist-wonderland" target="_blank">protist wonderland</a> (Microbe)</li> <li><i>Emiliania huxleyi</i> <a href="http://www.soes.soton.ac.uk/staff/tt/" mce_href="http://www.soes.soton.ac.uk/staff/tt/" target="_blank">home page</a></li> <li><a href="http://www.ncbi.nlm.nih.gov/pubmed/22404582" mce_href="http://www.ncbi.nlm.nih.gov/pubmed/22404582" target="_blank">DISCO in the North Sea</a> (FEMS Microbiol Ecol)</li> <li>7000 years of <i>Emiliania huxleyi</i> <a href="http://www.sciencemag.org/content/333/6041/451.short" mce_href="http://www.sciencemag.org/content/333/6041/451.short" target="_blank">in the Black Sea</a> (Science)</li> <li><a href="http://www.pnas.org/content/105/41/15944.long" mce_href="http://www.pnas.org/content/105/41/15944.long" target="_blank">Cheshire cat escape</a> by <i id="">Emiliania huxleyi</i> (PNAS)</li> <li><a href="http://www.microbeworld.org/index.php?option=com_content&view=article&id=1212:twim-34-letters&catid=108:twim-letters&Itemid=278" mce_href="index.php?option=com_content&view=article&id=1212:twim-34-letters&catid=108:twim-letters&Itemid=278" target="_blank">Letters read</a> on TWiM 34</li> </ul>
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TWiM #33: Tuning the immune organ
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut.</span></p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" data-mce-style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px; white-space: normal; "></span></span></p> <h3 style="margin-top: 1em; margin-right: 0px; margin-bottom: 0.2em; margin-left: 0px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 1.2em; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #bc0101; font-weight: bold; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px;">Links for this episode:</h3> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" data-mce-style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px; white-space: normal; "></span></span></p> <ul style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; list-style-type: none; list-style-position: initial; list-style-image: initial; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px;"> <li style="padding-top: 0.2em; padding-right: 0px; padding-bottom: 0.2em; padding-left: 36px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 16px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; border-width: 0px; margin: 0px;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19836068" target="_blank" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">Induction of Th17 cells</a> by segmented filamentous bacteria (Cell)</li> <li style="padding-top: 0.2em; padding-right: 0px; padding-bottom: 0.2em; padding-left: 36px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 16px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; border-width: 0px; margin: 0px;"><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010405/?tool=pubmed" target="_blank" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">Segmented filamentous bacteria</a> take the stage (Nature)</li> <li style="padding-top: 0.2em; padding-right: 0px; padding-bottom: 0.2em; padding-left: 36px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 16px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; border-width: 0px; margin: 0px;">Genome of segmented filamentous bacteria <a href="http://www.ncbi.nlm.nih.gov/pubmed/21925113" target="_blank" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">reveals auxotrophy</a> (Cell)</li> <li style="padding-top: 0.2em; padding-right: 0px; padding-bottom: 0.2em; padding-left: 36px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: url('http://www.microbeworld.org/templates/microbeworld/images/_layout/bullet.gif'); background-attachment: initial; background-origin: initial; background-clip: initial; background-color: initial; line-height: 1.4em; height: 16px; background-position: 16px 0.35em; background-repeat: no-repeat no-repeat; border-width: 0px; margin: 0px;">Segmented filamentous bacteria and <a href="http://www.pnas.org/content/108/28/11548.abstract" target="_blank" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">diabetes protection</a> (PNAS)</li> </ul> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" data-mce-style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;" data-mce-style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px; white-space: normal; "></span></span></p> <p style="margin-top: 0.2em; margin-right: 0px; margin-bottom: 1em; margin-left: 0px; border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px;">Send your microbiology questions and comments (email or mp3 file) to <a href="mailto:twim@twiv.tv" style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; color: #4da7d4; text-decoration: underline; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">twim@twiv.tv</a> , </p> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"><span class="Apple-style-span" style="font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px; white-space: normal;"></span></span></p>
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TWiM #32: Not the shadow biosphere
<p>Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus. </p>
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TWiM 31: Screen door on a submarine
<p style="font-family: 'Lucida Grande'; font-size: medium;">Hosts: <a target="_blank" href="http://www.virology.ws/" mce_href="http://www.virology.ws/">Vincent Racaniello</a>, <a href="http://bbs.yale.edu/molecularcell/researchpeople/jo_handelsman.profile" mce_href="http://bbs.yale.edu/molecularcell/researchpeople/jo_handelsman.profile" target="_blank">Jo Handelsman</a><span id="internal-source-marker_0.24935460928827524"><span id="internal-source-marker_0.7109660827554762"><span mce_style="font-weight: bold;" style="font-weight: bold;">, </span>and<span mce_style="font-weight: bold;" style="font-weight: bold;"> </span><a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" mce_href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank">Michael Schmidt</a></span></span></p> <p style="font-family: 'Lucida Grande'; font-size: medium;"><span id="internal-source-marker_0.24935460928827524"><span id="internal-source-marker_0.7109660827554762"><a href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" mce_href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" target="_blank"></a></span></span>Vincent, Jo, and Michael discuss an archetypal protein transport system in bacterial outer membranes, and evidence that gut microbial enterotypes might not fall into defined groups.</p> <p style="font-family: 'Lucida Grande'; font-size: medium;"><span class="Apple-style-span" style="font-weight: bold;">Links for this episode:</span></p> <ul style="font-family: 'Lucida Grande'; font-size: medium;"> <li>Discovery of a TAM, a new bacterial <a href="http://www.nature.com/nsmb/journal/vaop/ncurrent/full/nsmb.2261.html" mce_href="http://www.nature.com/nsmb/journal/vaop/ncurrent/full/nsmb.2261.html" target="_blank">protein transport system</a> (Nat Struct Mol Biol)</li> <li><a href="http://www.monash.edu.au/news/show/disarming-disease-causing-bacteria" mce_href="http://www.monash.edu.au/news/show/disarming-disease-causing-bacteria" target="_blank">Commentary</a> on TAM discovery</li> <li>Enterotypes of the <a href="http://www.nature.com/nature/journal/v473/n7346/full/nature09944.html" mce_href="http://www.nature.com/nature/journal/v473/n7346/full/nature09944.html" target="_blank">human gut microbiome</a> (Nature)</li> <li>Gut enterotypes might be <a href="http://www.nature.com/news/gut-microbial-enterotypes-become-less-clear-cut-1.10276" mce_href="http://www.nature.com/news/gut-microbial-enterotypes-become-less-clear-cut-1.10276" target="_blank">less clear-cut</a> (Ed Yong)</li> <li><a href="index.php?option=com_content&view=article&id=1179:twim-31-letters&catid=108:twim-letters&Itemid=278" mce_href="index.php?option=com_content&view=article&id=1179:twim-31-letters&catid=108:twim-letters&Itemid=278" target="_blank">Letters read</a> on TWiM #31</li> </ul>
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TWiM #30: Unraveling melioidosis and insulin resistance
<p class="p1">On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.</p>
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TWiM #29: Death and an iron-loaded spike
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #29 of the podcast, </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span><span id="internal-source-marker_0.8607104299589992">Vincent </span></span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.24935460928827524">and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.</span></span></p>
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TWiM #28: Not unorganized bags of enzymes
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Elio review how competition within a host drives virulence of </span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Streptococcus pneumoniae</span><span style="font-size: 16px; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">, and the expanding universe of the bacterial cytoskeleton.</span></p>
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TWiM #27: An inflamed gut is good for Salmonella
<p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Elio, and Michael review how inflammation allows </span><span style="font-size: 16px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Salmonella</span><span style="font-size: 16px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;"> to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.</span></p>
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TWiM #26: Suum cuique
<p><span style="font-size: medium;">Vincent, Elio, and Michael discuss the finding of <em>Sutterella</em> species in the gut of autistic children, and methods for cultivating oral bacteria. </span></p>
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TWiM #25: Magnetotactic bacteria and totally drug resistant TB
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><a href="images/stories/TWiM/break_magnet.jpg" mce_href="images/stories/TWiM/break_magnet.jpg" title="break magnet" target="_blank" class="jcebox"></a></span></p>
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TWiM #24: This year in microbiology
<div style="background-color: transparent;"> <p dir="ltr" style="margin-left: 4.5pt; margin-right: 4.5pt; text-indent: -4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.</span></p> </div>
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TWiM #23: Fighting antibiotics with toxic gas and starvation
<div style="background-color: transparent;"> <p dir="ltr" style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;"><span style="font-size: 16px; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap;">Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.</span></p> </div>
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TWiM #22: Microbiology 911
<p>Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.</p>
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TWiM #21: Symbiotic margheritas
<p>Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.</p>
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TWiM #20: Facebook for bacteria
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #20 of the podcast</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">This Week in Microbiology</span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;">, </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span>Vincent, Michael, and Elio follow up on the outbreaks of </span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">E. coli </span></span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span>in Germany and cholera in Haiti, then discuss genes that confer self-identity to </span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span>Proteus <span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">mirabilis</span>.<a href="images/stories/TWiM/proteus_territories.jpg" mce_href="images/stories/TWiM/proteus_territories.jpg" title="proteus territories" target="_blank" class="jcebox"></a></span></span></p>
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TWiM #19: Your microbiome is what you eat
<p>Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.</p>
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TWiM #18: Escherichia coli K-12, an emerging pathogen?
<p>Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.</p>
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TWiM #17: Debugging endosymbiosis
<p style="margin: 0.0px 0.0px 0.0px 0.0px; font: 16.0px Calibri;">Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of <i>Ricekttsia</i> in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.</p> <div></div>
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TWiM #16: ICAAC Live
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #16 of the podcast</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">This Week in Microbiology</span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;">, </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span><a href="http://www.virology.ws/" mce_href="http://www.virology.ws/" target="_blank">Vincent</a>, <a id="internal-source-marker_0.4825304050464183" href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html" mce_href="http://academicdepartments.musc.edu/immunology/Faculty/schmidt.html"><span>Michael</span></a><span>, </span><a href="http://www.einstein.yu.edu/home/faculty/profile.asp?id=3478" mce_href="http://www.einstein.yu.edu/home/faculty/profile.asp?id=3478"><span>Arturo</span></a><span>, </span><a href="http://www.tufts.edu/med/microbiology/faculty/levy/" mce_href="http://www.tufts.edu/med/microbiology/faculty/levy/"><span>Stuart</span></a><span>, and </span><span><a href="http://www.hpa.org.uk/ProductsServices/InfectiousDiseases/LaboratoriesAndReferenceFacilities/AntibioticResistanceMonitoringAndReferenceLaboratory/" mce_href="http://www.hpa.org.uk/ProductsServices/InfectiousDiseases/LaboratoriesAndReferenceFacilities/AntibioticResistanceMonitoringAndReferenceLaboratory/">David</a></span> converse about antimicrobial resistance and why most fungi do not cause disease at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).<a class="jcebox" target="_blank" title="ICAAC 2011" href="images/stories/TWiM/icaac2011.png" mce_href="images/stories/TWiM/icaac2011.png"></a></span></span></p>
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TWiM #15: Microbial long distance relationships
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #15 of the podcast</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">This Week in Microbiology</span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;">, Vincent</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.8056849467102438">, Michael and Jo review the number of species on Earth, evidence that the 2010 Haitian cholera outbreak originated in Nepal, and how gut microbiota influence the immune response to influenza virus infection of the lung. <a href="http://mbio.asm.org/content/2/4/e00157-11/F2.large.jpg" mce_href="http://mbio.asm.org/content/2/4/e00157-11/F2.large.jpg" target="_blank" class="jcebox"></a></span></span></p>
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TWiM #14: Vomocytosis and microbial transistors
<p><span class="Apple-style-span" style="font-family: Times; font-size: medium;">On episode #14 of the podcast</span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"> </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">This Week in Microbiology</span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;">, </span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span id="internal-source-marker_0.8056849467102438">Stanley, Margaret, Michael and Elio review how the fungus </span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Cryptococcus</span></span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span> escapes from macrophages, and electrical conductivity in nanowires formed by the bacterium </span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span><span mce_name="em" mce_style="font-style: italic;" class="Apple-style-span" style="font-style: italic;">Geobacter</span></span></span><span class="Apple-style-span" style="font-family: Times; font-size: medium;"><span>.</span></span></p>
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TWiM #13: Probiotics and inflammasomes: Telling good bacteria from the bad
<p><span class="Apple-style-span" style="border-collapse: collapse; font-family: Helvetica, Arial, FreeSans, sans-serif; font-size: 12px; line-height: 16px;">On episode #13 of the podcast <em style="border-style: initial; border-color: initial; outline-width: 0px; outline-style: initial; outline-color: initial; font-size: 12px; vertical-align: baseline; background-image: initial; background-attachment: initial; background-origin: initial; background-clip: initial; background-color: transparent; background-position: initial initial; background-repeat: initial initial; border-width: 0px; padding: 0px; margin: 0px;">This Week in Microbiology</em>, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a probiotic-derived soluble protein to the colon.</span></p>
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TWiM #12: Photothermal nanoblades and genome engineering
<p><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;" id="internal-source-marker_0.6275083124466687">Vincent, Margaret, Michael and Elio review the use of photothermal nanoblades to dissect the </span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline;">Burkholderia</span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> intracellular life cycle, and manipulation of chromosomes </span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline;">in vivo</span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;"> for genome-wide codon replacement in </span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline;">E. coli</span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline;">.</span></p>
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TWiM #11: Chickens, antibiotics, and asthma
<p>Vincent, Margaret, Michael and Elio review the presence of extended spectrum beta-lactamase genes in chicken meat and in humans, and a beneficial effect of Helicobacter pylori colonization on the development of allergen-induced asthma.</p>
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TWiM #10: A symbiotic cloaking device
<p>On episode #10 of the podcast <em>This Week in Microbiology</em>, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri.</p>
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TWiM #9: Bean sprouts and E. coli O104:H4
<p style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" id="internal-source-marker_0.5201739400962169"><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">Vincent, Michael, and Cliff</span><span style="font-size: 12pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;"> review the outbreak of bloody diarrhea and hemolytic uremic syndrome in Germany caused by</span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;"> Shiga toxin-producing </span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; text-decoration: none; vertical-align: baseline;">Escherichia coli</span><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;"> O104:H4.</span></p>
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TWiM # 8: Live in NOLA
<p style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" id="internal-source-marker_0.31120804751057785"><span style="font-size: 12pt; font-family: Arial; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">Vincent, Michael, and Stanley recorded TWiM #8 live </span><span style="font-size: 12pt; font-family: Arial; color: #111111; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">at the 2011 ASM General Meeting in New Orleans, with guests Andreas Baümler, Nicole Dubilier, and Paul Rainey. They spoke about how pathogens benefit from disease, </span><span style="font-size: 12pt; font-family: Verdana; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">symbioses between chemosynthetic bacteria and marine invertebrates, and repetitive sequences in bacteria.</span><span style="font-size: 12pt; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;"></span></p>
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TWiM #7: Cycles of life and death, light and dark
<p style="margin-right: 4.5pt; margin-top: 0pt; margin-bottom: 0pt;" id="internal-source-marker_0.7693870353490643"><span style="font-size: 12pt; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">Vincent, Cliff, Elio, Margaret, and Michael discuss programmed cell death in </span><span style="font-size: 12pt; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: italic; text-decoration: none; vertical-align: baseline;">E. coli</span><span style="font-size: 12pt; font-family: Calibri; color: #000000; background-color: transparent; font-weight: normal; font-style: normal; text-decoration: none; vertical-align: baseline;">, and the daily synthesis and degradation of enzymes needed for photosynthesis and nitrogen fixation by cyanobacteria.</span></p>
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TWiM #6: Antibacterial therapy with bacteriophage: Reality or fiction?
<p>Vincent, Cliff, Michael and Elio review the use of bacteriophages to manage infections, and the presence of antibiotic resistance genes in the bacteriophage from urban sewage and river water.</p>
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TWiM #5: Mercury-methylating Desulfovibrio and antimicrobial nanoparticles
<p><span style="font-family: calibri;" face="calibri"><span style="font-size: small;" size="3">Vincent, Ron, Cliff, and Michael discuss the genome sequence of a mercury-methylating bacterium and the antimicrobial effects of nanoparticles.</span></span></p>
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TWiM #4: Cantaloupes and Salmonella gastroenteritis
<p><span style="font-family: calibri;"><span style="font-size: small;">Vincent, Cliff, Margaret, and Michael </span></span><span style="font-size: small;"><span style="font-family: calibri;">review foodborne bacterial illness in the context of outbreaks associated with cantaloupes and Lebanon bologna.</span></span></p>
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TWiM #3: Anthrax, genomics and the FBI inquiry
<p>Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.</p>
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TWiM #2: The plague, microbial virulence and the gut microbiome
<p>Vincent, Cliff, and Michael review a fatal laboratory acquired <em>Yersinia pestis</em> infection, and how gut bacteria control body weight and metabolic activity.<a class="jcebox" href="http://www.microbeworld.org/images/stories/TWiM/f3.large.jpg" target="_blank"></a><a class="jcebox" href="http://www.microbeworld.org/images/stories/TWiM/f3.large.jpg" target="_blank"><span style="float: right;"></span></a></p>
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TWiM #1: Neisseria LINEs up
<p>On episode #1 of the podcast <em>This Week in Microbiology</em>, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.</p>
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